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Direct Damage of Myocardium by Enterovirus

  • B. McManus
  • L. H. Chow
  • J. E. Wilson
  • D. R. Anderson
  • R. Kandolf
Conference paper

Abstract

Human idiopathic myocarditis has long troubled those interested in establishing cause(s) and identifying efficacious therapies. To date, neither the cause nor specific therapies are known. Perhaps these difficulties relate to the ambiguities of clinical presentation, the poorly characterized natural history, and the lack of distinctive therapeutic targets. Nonetheless, continued efforts worldwide to understand inflammatory heart disease have reestablished a view that viruses, and particularly enteroviruses, play a pathogenetic role in at least some human myocarditides. Summary experience from several investigators suggests that approximately 25% of inflamed failing and/or arrhythmic hearts are attributable to enterovirus infections [1, 2]. The frequency of other community-acquired viral infections involving the heart is much less clear. Even more uncertain is the manner in which viruses may effect injury in the human heart. Hypotheses abound, but little in the way of solid data is available. The role of virus in direct injury of the myocardium has appeared more convincing in fulminant infantile myocarditis where enterovirus is often isolated and/or demonstrated by molecular techniques (McManus, unpublished data). Autoimmune phenomena are often concomitants of human myocarditis and dilated cardiomyopathy [3], but their pathogenetic significance has not been established.

Keywords

Dilate Cardiomyopathy Direct Damage Enteroviral Infection Nuclear Track Emulsion Inflammatory Heart Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    McManus BM (1990) Progress in resolving diagnostic, etiogenetic and therapeutic issues in myocarditis. In: Fenoglio-Prieser C (ed) Advances in pathology. Year Book Medical Publishers, Chicago, pp 139–171Google Scholar
  2. 2.
    McManus BM, Kandolf R (1991) Evolving concepts of cause, consequence, and control in myocarditis. Curr Opin Cardiol 6:418–427CrossRefGoogle Scholar
  3. 3.
    Caforio ALP, Grazzini M, Mann JM et al. (1992) Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy. Circulation 85:1734–1742PubMedGoogle Scholar
  4. 4.
    McManus BM, Chow LH, Wilson JE et al. (1992) Direct myocardial injury by enterovirus: a central role in the evolution of murine myocarditis. In: Rose N (ed) Immune-mediated heart disease. Springer, Berlin Heidelberg New York, (in press)Google Scholar
  5. 5.
    Kandolf R, Canu A, Hofschneider PH (1985) Coxsackie B3 virus can replicate in cultured human fetal heart cells and is inhibited by interferon. J Mol Cell Cardiol 17:167–181PubMedCrossRefGoogle Scholar
  6. 6.
    Chow LH, Beisel K, McManus BM (1991) Differentiation of viral and immune factors in pathogenesis of myocarditis: immune deficient and normal mice. Lab Invest 64:17AGoogle Scholar
  7. 7.
    Kandolf R, Ameis D, Krischner P, Canu A, Hofschneider PH (1987) “In situ” detection of enteroviral genomes in myocardial cells by nucleic acid hybridization: an approach to the diagnosis of viral heart disease. Proc Natl Acad Sci USA 84:6272–6276PubMedCrossRefGoogle Scholar
  8. 8.
    Chow LH, Beisel KW, McManus BM (1992) Enteroviral infection of mice with severe combined immunodeficiency : evidence for direct viral pathogenisis of myocardial injury. Lab Invest 66:24–31PubMedGoogle Scholar
  9. 9.
    Hofschneider PH, Klingel K, Kandolf R (1990) Toward understanding the pathogenesis of enterovirus-induced cardiomyopathy: molecular and ultrastructural approaches. J Struct Biol 104:1–6CrossRefGoogle Scholar
  10. 10.
    Godman GC (1966) The cytopathology of enteroviral infection. Int Rev Exp Pathol 5:67–110PubMedGoogle Scholar
  11. 11.
    Mims CA (1989) The pathogenetic basis of viral tropism. Am J Pathol 135:447–455PubMedGoogle Scholar
  12. 12.
    Gifford R, Dalldorf G (1951) The morbid anatomy of experimental coxsackie virus infection. Am J Pathol 27:1047–1063PubMedGoogle Scholar
  13. 13.
    Rabin ER, Hassan SA, Jenson AB, Melnick JL (1964) Coxsackie virus B3 myocarditis in mice: an electron microscopic, immunofluorescent and virus-assay study. Am J Pathol 44:775–797PubMedGoogle Scholar
  14. 14.
    Deguchi H (1981) Ultrastructural alterations of the myocardium in coxsackie B-3 virus myocarditis in mice: 18 month follow-up study by transmission and analyticl electron microscopy. Jpn Circ J 45:695–712PubMedCrossRefGoogle Scholar
  15. 15.
    RS Sohal, Burch GE (1969) Ultrastructural lesions of the myocardial cell in coxsackie B4 virus infected mice. Virchows Arch [A] 346:361–373Google Scholar
  16. 16.
    Morita H (1981) Experimental coxsackie B3 virus myocarditis in golden hamsters. Jpn Circ J 45:713–729PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • B. McManus
    • 1
  • L. H. Chow
    • 2
  • J. E. Wilson
    • 1
  • D. R. Anderson
    • 1
  • R. Kandolf
    • 3
  1. 1.Cardiovascular Registry, Department of Pathology and MicrobiologyUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Robarts Research InstituteUniversity of Western OntarioLondonCanada
  3. 3.Max Planck Institute for BiochemistryFed. Rep. of Germany

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