Capillary Density, Distribution, and Length Parameters Related to Oxygen Supply in Myocardial Hypertrophy and Atrophy
Cardiac muscle is well known to be vulnerable to anoxia, even for a very short duration, due to its almost entirely oxidative metabolism. For proper cardiac function the balance between oxygen supply and demand must be met not only at the level of the whole organ but also at that of the individual working units, i.e. cardiac myocytes. Previous attempts to measure the adequacy of the oxygen supply-to-demand ratio were limited by an emphasis on measuring the basic parameters only at the level of the whole organ. This was due mainly to lack of data on the local distribution of oxygen sources and sinks, i.e. basic supply and demand elements. Recent developments in the quantitative analysis of cardiac tissue should permit such an investigation at the tissue level as well.
KeywordsAnisotropy Cardiomyopathy Cardiol Myopathy Dick
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