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Capillary Density, Distribution, and Length Parameters Related to Oxygen Supply in Myocardial Hypertrophy and Atrophy

  • K. Rakusan
  • S. Batra
  • P. Veprek
  • Z. Turek
Conference paper

Abstract

Cardiac muscle is well known to be vulnerable to anoxia, even for a very short duration, due to its almost entirely oxidative metabolism. For proper cardiac function the balance between oxygen supply and demand must be met not only at the level of the whole organ but also at that of the individual working units, i.e. cardiac myocytes. Previous attempts to measure the adequacy of the oxygen supply-to-demand ratio were limited by an emphasis on measuring the basic parameters only at the level of the whole organ. This was due mainly to lack of data on the local distribution of oxygen sources and sinks, i.e. basic supply and demand elements. Recent developments in the quantitative analysis of cardiac tissue should permit such an investigation at the tissue level as well.

Keywords

Capillary Density Aortic Valve Stenosis Myocardial Hypertrophy Idiopathic Dilate Cardiomyopathy Capillary Supply 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • K. Rakusan
    • 1
  • S. Batra
    • 1
  • P. Veprek
    • 2
  • Z. Turek
    • 3
  1. 1.Department of PhysiologyUniversity of OttawaOttawaCanada
  2. 2.KardiocentrumPragueCzechoslovakia
  3. 3.Department of PhysiologyUniversity of NijmegenNijmegenThe Netherlands

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