Abstract
This paper describes our calibration technique to derive the absolute cross-sectional area of diseased blood vessel lumen from X-ray angiograms. This technique relies on the identification of a blood vessel of circular cross-section near to the diseased segment. If we assume that the concentration of contrast material and the densitometric response of the imaging system are constant over the diseased segment we may apply the calibration factor derived from adjacent circular segments to the diseased segment. Our interactive computer program, which incorporates this procedure, has been validated for segments of diseased coronary artery obtained at post mortem. Comparison with photographs of cross-sections of the arteries yielded a standard error of the estimate of 0.47mm2 using cine fluorography with samples every 0.3mm along the artery’s axis and film-screen radiography with samples every 0.1mm. The X-ray and geometric projections of the arterial cross-sections were consistent within the expected accuracy of the experiment. For the film-screen the precision of the densitometric profiles was approximately 0.1mm with systematic calibration errors of upto 0.2mm. There is considerable information in the X-ray projection data which could be used for the analysis of lumen shape, and hence the classification of vascular pathology.
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© 1992 Springer-Verlag Berlin Heidelberg
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Hawkes, D.J., Colchester, A.C.F., de Belder, M.A., Norbury, R.N., Camm, A.J., Davies, M.J. (1992). The Measurement of Absolute Lumen Cross Sectional Area and Lumen Geometry in Quantitative Angiography. In: Todd-Pokropek, A.E., Viergever, M.A. (eds) Medical Images: Formation, Handling and Evaluation. NATO ASI Series, vol 98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77888-9_32
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DOI: https://doi.org/10.1007/978-3-642-77888-9_32
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