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Modulation of Fibroblastic Cytoskeletal Features During Wound Healing and Fibrosis

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Wound Healing and Skin Physiology

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Abstract

The mechanisms leading to the retraction of granulation tissue during wound healing have not been presently fully elucidated (for review, see Schürch et al. 1992). Several years ago, our laboratory described the presence within granulation tissue of fibroblasts having several ultrastructural features of smooth muscle (SM) cells, including the presence of microfilament bundles with dense bodies scattered within (Gabbiani and Majno 1972). These cells, called myofibroblasts, have been proposed to play a retractile role in several conditions such as granulation tissue contraction, parenchymal organ retraction, fibromatosis and stromal reaction to epithelial tumors (Sappino et al. 1988, 1990a; Skalli et al. 1989; Darby et al. 1990; Kapanci et al. 1990; Schmitt-Gräff and Gabbiani 1992; for review, see Sappino et al. 1990b). The coincidence of the presence of myofibroblasts with retractile phenomena has supported this hypothesis. However, direct proof of the presence and activity of contractile elements in myofibroblasts has been possible only after suitable techniques have been developed in order to localize and quantify cytoskeletal and contractile proteins within the affected organs. For this purpose, advances in the understanding of cytoskeletal and contractile element morphology and biochemistry in different cells have been of great help (for review, see Skalli and Gabbiani 1988, 1990).

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Author notes

  1. A. Desmoulière & G. Gabbiani

    Present address: Institut Pasteur de Lyon, CNRS-URA 1459, Avenue Tony Gamier, 69365, Lyon Cedex 7, France

Authors and Affiliations

  1. Department of Pathology, University of Geneva, Centre Médical Universitaire, 1, rue Michel Servet, 1211, Geneva 4, Switzerland

    A. Desmoulière & G. Gabbiani

Authors
  1. A. Desmoulière
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  2. G. Gabbiani
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Editors and Affiliations

  1. Dermatologische Klinik im St. Josef-Hospital, Ruhr-Universität, Gudrunstr. 56, 44791, Bochum, Germany

    Peter Altmeyer , Klaus Hoffmann  & Stephan el Gammal ,  & 

  2. ConvaTec Wound Healing Institute, Deeside, Clwyd, CH5 2NU, UK

    Jerry Hutchinson

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© 1995 Springer-Verlag Berlin Heidelberg

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Desmoulière, A., Gabbiani, G. (1995). Modulation of Fibroblastic Cytoskeletal Features During Wound Healing and Fibrosis. In: Altmeyer, P., Hoffmann, K., el Gammal, S., Hutchinson, J. (eds) Wound Healing and Skin Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77882-7_9

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  • DOI: https://doi.org/10.1007/978-3-642-77882-7_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56124-8

  • Online ISBN: 978-3-642-77882-7

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