Both Wet and Moist Wound Environments Accelerate Cutaneous Healing
Since the early reports on skin wound treatment, showing that skin wounds epithelialize more rapidly under moist conditions than under dry [1, 2], a variety of water and gas permeable dressings have been developed. The principle findings of healing in a moist environment are acceleration of epithelialization and prevention of the progression of wound depth that is observed in a dry environment. In a previous study we have shown that if a skin wound is continuously kept in a liquid environment consisting of saline and cell culture concentrations of penicillin and streptomycin, eschar formation was reduced and the time of epithelialization accelerated as compared to air exposed wounds . In this study we have directly compared three different conditions under which porcine partial excisional wounds can heal: Wet (saline in an occlusive vinyl chamber), moist (hydrocolloid) and dry (air exposure under gauze dressing).
KeywordsPermeability Formalin Migration Penicillin Vinyl
Unable to display preview. Download preview PDF.
- 7.Jonkman MF (1989) Epidermal wound healing between moist and dry. Thesis, Rijksuni-versiteit, Groningen.Google Scholar
- 12.Breuing K, Marikovsky M, Klagsbrun M, Liu YP, Binder T, Miller DR, Eriksson E (1991) EGF-like growth factor present in porcine wound fluid. Surg Forum XLII:623–625.Google Scholar
- 13.Brem H, Yuen S, Watanabe H, Tamvakopoulis G, Marikovski M, Vogt PM, Klagsbrun M, Reiksson E, Grosfeld J, Folkman J (1992). Time dependent expression of bFGF during wound healing. Surg Forum (in press).Google Scholar
- 14.Eriksson E, Liu PY, Zeckel Y, Binder T, Breuing K, Miller DR (1991) In vivo cell culture accelerates reepithelialization. Surg Forum XLI:670–673.Google Scholar
- 15.Vogt PM, Thompson S, Binder T, Mulligan R, Eriksson E (1992) In-vitro/in-vivo expression of human growth hormone in porcine keratinocytes after retroviral gene transfer. Surg Forum XLIII:691–694.Google Scholar