Abstract
Venous ulceration is a common problem in clinical practice. Although it is quite clear that venous insufficiency is the underlying cause, the exact pathogenetic mechanism is still not fully understood and definitively very complex.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Gay J (1868) On varicose disease of the lower extremities: the Lettsomian lectures of 1867. Churchill, London.
Homans J (1917) The aetiology and treatment of varicose ulcers of the leg. Surg Gynaecol Obstet 24:300–311.
Linton RR (1938) The communicating veins of the lower limb and the operating technique for their ligation. Ann Surg 107:582–593.
Brewer AC (1950) Varicose ulceration. Br Med J 2:270.
Fearnley G (1965) Fibrinolysis. Arnold, London.
Browse NL, Gray L, Larret PM, Morland M (1977) Blood and vein-wall fibrinolytic activity in health and vascular disease. Br Med J 1:478–481.
Browse NL (1983) Venous ulceration. Br Med J 286:1920–1922.
Burnand KG, Whimster I, Naidoo A, Browse NL (1982) Pericapillary fibrin in the ulcer bearing skin of the lower leg: the cause of lipodermatosclerosis and venous ulceration. Br Med J 285:1071–1072.
Browse NL, Burnand KG (1982) The cause of venous ulceration. Lancet 2:243–245.
Fagrell B (1982) Microcirculatory disturbances — the final cause for venous leg ulcers?. Vasa 11:101–103.
Ernst E, Matrai A, Vinnemeier E, Marshall M (1986) Blood rheology in post-thrombotic syndrome — a pilot study. Phlebology 3:181–183.
Franzeck UK, Huch A, Huch R, Bollinger A (1982) Simultane transcutane PO2-Messung und Videomikroskopie bei Patienten mit chronisch-venöser Insuffizienz. Vasa 9:19.
Thomas PRS, Nash GB, Dormandy JA (1988) White cell accumulation in dependent legs of patients with venous hypertension: a possible mechanism for trophic changes in the skin. Br Med J 296:1693–1695.
Coleridge Smith PD, Thomas P, Scurr JH, Dormandy JA (1988) Causes of venous ulceration: a new hypothesis. Br Med J 296:1726–1727.
Ackerman Z, Seidenbaum M, Loewenthal E, Rubinow A (1988) Overload of iron in the skin of patients with varicose ulcers. Arch Dermatol 124:1376–1378.
Arnoldi CC, Linderholm H (1968) On the pathogenesis of the venous leg ulcer. Acta Chir Scand 134:427.
Wenner A et al. (1980) Ultrastructural changes of capillaries in chronic venous insufficiency. Exp Cell Biol 48:1–14.
Leu HJ, Wenner A, Spycher MA, Brunner U (1980) Veränderungen der transendothelialen Permeabilität als Ursache des Oedems bei der chronisch-venösen Insuffizienz. Phlebol Proktol 9:67–73.
Shirley HH, Wolfram CG, Wasserman K, Mayerson HS (1967) Capillary permeability to macromolecules: stretched pore phenomen. Physiology 190:189–193.
Ryan TJ (1989) Structure and function of lymphatics. J Invest Dermatol 93(2):18–24.
Zabel M, Hettwer H (1987) Zur Pathogenese der Atrophie blanche — histologische und elektronen-optische Untersuchungen. Phlebol Proktol 16:151.
Franzeck UK, Isenring G, Frey J, Jäger K, Mahler F, Bollinger A (1983) Eine Apparatur zur dynamischen intravitalen Videomikroskopie. Vasa 12:233–238.
Westerhof W, Mekkes JR (1990) Krill and other enzymes in enzymatic wound debridement. In: Wadstrom T, Eliasson I, Holder I, Ljungh A (eds) Pathogenesis of wound and biomaterial-associated infections. Springer, London.
Dutrieux RP, van Ginkel CJW, Westerhof W (1989) Groeifactoren en de wondgenezing: fictie of realiteit?. Ned Tijdschr Geneeskd 133:1870–1872.
Jansen FC, Westerhof W, Cormane RH (1986) Transplantatie van autologe huidbiopten: een doeltreffende Klinische behandeling van het ulcus cruris. Ned Tijdschr Geneeskd 130:1230–1233.
Leigh IM, Purkis PE, Navsaria HA et al. (1987) Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes. Br J Dermatol 117:591–597.
Mol MAE, Nanninga PB, van Eendenburg JP, Mekkes JR, Westerhof W, van Ginkel CJW (1991) Grafting of venous leg ulcers: an intra-individual comparison between cultured skin equivalents and full thickness skin punches. J Am Acad Dermatol 24:77–82.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Mekkes, J.R., Westerhof, W. (1995). Pathophysiology of Wound Healing in Venous Leg Ulcers. In: Altmeyer, P., Hoffmann, K., el Gammal, S., Hutchinson, J. (eds) Wound Healing and Skin Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77882-7_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-77882-7_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-56124-8
Online ISBN: 978-3-642-77882-7
eBook Packages: Springer Book Archive