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Wound Healing and Skin Physiology pp 33–43Cite as

Histological Examination of Skin Grafts

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Abstract

Surface epithelial tissue of the skin belongs to the Wechselgewebe (regenerating tissue) due to the rapid proliferation of the cells. Under physiological conditions the continuous supply of cells results from the mitotic cells of the stratum germinativum (Cottier 1980). In traumatic injury of the skin, there is an interruption of tissue continuity with destruction of all epidermal cell layers and of concomitant mesenchymal and vascular tissue; thus a restitutio ad integrum due to proliferation of the germinative cell layer of the epithelial surface of the skin is not possible. Complex reparative and regenerative changes of wound healing, proceeding in three phases, are necessary: In the first phase the wound is covered with blood and a fibrin clot, which is the first barrier against infection. Tissue at the border of the damage becomes necrotic with migration and demarcation of necrosis by granulocytes. The second phase of wound healing is characterized by proliferation of angioblasts, fibroblasts, histiocytes, lymphocytes and plasma cells resulting in granulation tissue. Proliferation of connective tissue leads to skin scarring in a third phase.

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Author information

Authors and Affiliations

  1. Institute of Pathology, Berufsgenossenschaftliche Kliniken “Bergmannsheil”, University Clinic, Gilsingstrasse 14, 44789, Bochum, Germany

    A. Fisseler-Eckhoff & K.-M. Müller

Authors
  1. A. Fisseler-Eckhoff
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  2. K.-M. Müller
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Editor information

Editors and Affiliations

  1. Dermatologische Klinik im St. Josef-Hospital, Ruhr-Universität, Gudrunstr. 56, 44791, Bochum, Germany

    Peter Altmeyer , Klaus Hoffmann  & Stephan el Gammal ,  & 

  2. ConvaTec Wound Healing Institute, Deeside, Clwyd, CH5 2NU, UK

    Jerry Hutchinson

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© 1995 Springer-Verlag Berlin Heidelberg

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Fisseler-Eckhoff, A., Müller, KM. (1995). Histological Examination of Skin Grafts. In: Altmeyer, P., Hoffmann, K., el Gammal, S., Hutchinson, J. (eds) Wound Healing and Skin Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77882-7_4

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  • DOI: https://doi.org/10.1007/978-3-642-77882-7_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56124-8

  • Online ISBN: 978-3-642-77882-7

  • eBook Packages: Springer Book Archive

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