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Phosphocreatine Ameliorates Structural Integrity of Ischemic Skin Flaps

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Wound Healing and Skin Physiology
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Abstract

Plastic surgery, since its inception, has been concerned with the restoration and reconstruction of body structures that are defective or have been damaged by injury or disease. Central to the armentarium of the plastic surgeon is the reconstructive skin flap. Recently the use of simple skin flaps has yielded increasingly to the use of composite flaps, which contain any combination of muscle, bone, or fascia in addition to skin and subcutaneous tissue.

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References

  • Beizer FO, Sollinger HW, Glass NR, Miller DT (1983) Beneficial effects of adenosine and phosphate in preservation. Transplantation 36(6):633.

    Article  Google Scholar 

  • Chait LA (1978) The effects of the perfusion of various solutions on the no-reflow phenomenon in experimental free flaps. Plast Reconstr Surg 61:421.

    Article  PubMed  CAS  Google Scholar 

  • Cormack GC, Lamberty BGH (1986) Changes in the vascularity of pig skin expanded with inflatable expanders. Br J Plast Surg 76:104–109.

    Google Scholar 

  • Cuono CB, Armitage IA, Marquetand R, Chapo GL (1988a) Nuclear magnetic resonance spectroscopy of skin: predictive correlates for clinical application. Plast Reconstr Surg 81(1):1.

    Article  PubMed  CAS  Google Scholar 

  • Cuono CB, Cortes A, Marquetand BS (1988b) Skin flap survival via post-operative phosphocreatine replacement. Surgery 102(2):263.

    Google Scholar 

  • Girffiths RW, Humphries NL (1981) Isoxuprine and the rat abdominal pedicled flap: a controlled study. Br J Plast Surg 34:446–450.

    Article  Google Scholar 

  • Harashina T, Buncke HJ (1975) Study of washout solutions for microvascular replantation and transplantation. Plast Reconstr Surg 56:542.

    Article  PubMed  CAS  Google Scholar 

  • Heckler FR (1984) Metabolic support for ischemic skin flaps with fructose-1,6p-diphosphate. Surg. Forum 35:580–582.

    Google Scholar 

  • Hendel PM (1983) A study of the pharmacological control of blood flow to acute skin flaps using xenon washout, part I. Plast Reconstr Surg 71(3):387–398.

    Article  PubMed  CAS  Google Scholar 

  • Jansson LE, Jurell G, Nylen B, Pandeya N (1975) Effects of phentolamine and propanolol on the survival of experimental skin flaps. Scand J Plast Reconstr Surg 9:98–100.

    Article  Google Scholar 

  • Jurell G, Fredholm BB (1981) Early changes in ATP and cyclic AMP levels in experimental critical skin flaps. Acta Physiol Scand 113:33–36.

    Article  PubMed  CAS  Google Scholar 

  • Marzalla L, Jasudass RR, Manson PN (1988) Functional and structural evaluation of the vasculature of skin flaps after ischemia and reperfusion. Plast Reconstr Surg 81:742–750.

    Article  Google Scholar 

  • McGregor JA, Morgan G (1963) Random pattern flaps. Br J Plast Surg 26:202.

    Article  Google Scholar 

  • Nichida T, Koseki M, Kanuicke W, Nakahara M (1987) Levels of purine compounds in a perfusate as a biochemical marker of ischemic injury of cold preserved liver. Transplantation 44:16.

    Article  Google Scholar 

  • Pearl RM (1981) A unifying theory of the delay phenomenon-recovery from the hyperadrenergic state. Ann Plast Surg 7:102–112.

    Article  PubMed  CAS  Google Scholar 

  • Pegg DE (1981) Perfusion technology. In: Karrow AM, Pegg DE (eds) Organ preservation and transplantation. Dekker, New York, pp 477–497.

    Google Scholar 

  • Trump BE (1976) Studies on the subcellular pathophysiology of ischemia. Circulation 53(3): 117–126.

    Google Scholar 

  • Willms-Kretschmer K, Majno G (1969) Ischemia of the skin: electron microscopy of vascular injury. Am J Pathol 54(3):327–343.

    PubMed  CAS  Google Scholar 

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© 1995 Springer-Verlag Berlin Heidelberg

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Stepke, M.T., Eichhorn, W., Schwenzer, N., Voy, E.D. (1995). Phosphocreatine Ameliorates Structural Integrity of Ischemic Skin Flaps. In: Altmeyer, P., Hoffmann, K., el Gammal, S., Hutchinson, J. (eds) Wound Healing and Skin Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77882-7_29

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  • DOI: https://doi.org/10.1007/978-3-642-77882-7_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56124-8

  • Online ISBN: 978-3-642-77882-7

  • eBook Packages: Springer Book Archive

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