Abstract
With increasing life expectancy, the number of diabetic patients requiring surgery increases. Micro- and macroangiopathic lesions are responsible for infections and prolonged wound healing periods. Therefore we decided to do a standardized experimental study on wound healing in pedicled skin flaps in streptozocin treated diabetic Wistar rats. Streptozocin specifically destroys the β-cells of the pancreas (Gerritsen and Dulin 1967; Junod et al. 1967; Tomita et al. 1986). The severity of the experimentally produced diabetes corresponds strictly to the dose of streptozocin administered (Junod et al. 1969; Tancrede et al. 1983; Ehrenfeld et al. 1988).
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© 1995 Springer-Verlag Berlin Heidelberg
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Eichhorn, W., Stepke, M., Riediger, D., Schwenzer, N., Voy, E.D. (1995). Studies on Wound Healing in Axial Pattern Flaps of the Diabetic Rat. In: Altmeyer, P., Hoffmann, K., el Gammal, S., Hutchinson, J. (eds) Wound Healing and Skin Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77882-7_25
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DOI: https://doi.org/10.1007/978-3-642-77882-7_25
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