Abstract
After thermal injury fluctuations in blood platelet levels have been reported. Eurenius et al. (1972) found that when 30% full-thickness burn wounds were induced in rats, a thrombocytopenia occurred within the first few hours of injury followed by a thrombocythaemia which reached a maximum between 3–5 days. Similar blood platelet level fluctuations have been observed in humans, albeit with a more prolonged time course (Baxter 1974).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baumgartner HR, Muggli R, Tschopp TB (1980) Interaction of platelets with subendothelium in flowing blood. In: Rotman A, Meyer FA, Gitler C, Silberberg A (eds) Platelets. Cellular response mechanisms and their biological significance. Wiley, Chichester, p 17.
Baxter CR (1974) Fluid volume and electrolyte changes of the early post burn period. Clin Plast Surg 1:693.
Boykin JV, Eriksson E, Pittman RN (1980) In vivo microcirculation of a scald burn and the progression of postburn dermal ischaemia. Plast Reconstr Surg 66(2): 191–198.
Brown D, Garner W, Young LV (1990) Skin grafting: dermal components in inhibition of wound contraction. South Med J 83(7):789–795.
Davidson J, Buckley A, Woodward S, Nichols W, McGee G, Demetriou A (1988) Mechanisms of accelerated wound repair using epidermal growth factor and basic fibroblast growth factor. In: Barbul A, Pines E, Caldwell M, Hunt TK (eds) Growth factors and other aspects of wound healing. Biological and clinical implications. Liss, New York, p 63.
Ehrlich HP (1988) The role of connective tissue matrix in wound healing. In: Barbul A, Pines E, Caldwell M, Hunt TK (eds) Growth factors and other aspects of wound healing. Biological and clinical implications. Liss, New York, p 243.
Eurenius K, Moretensen RF, Meserol PM, Curreri PW (1972) Platelet and megakaryocyte kinetics following thermal injury. J Lab Clin Med 79:247.
Gabbiani G, Ryan GB, Majno G (1971) Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experimentia 27:249.
Grotendorst GR, Grotendorst CA, Gilman T (1988) Production of growth factors (PDGF and TGF-β) at the site of tissue repair. In: Barbul A, Pines E, Caldwell M, Hunt TK (eds) Growth factors and other aspects of wound healing. Biological and clinical implications. Liss, New York, p 47.
Holmsen H, Dangelmaier CA, Holmsen HK (1981) Thrombin-induced platelet responses differ in requirement for receptor occupancy. Evidence for tight coupling of occupancy and compartmentalised phosphatidic acid formation. J Biol Chem 256:9393–9396.
Johansson SA (1960) 5-hydroxytryptamine in burns. Acta Physiol Scand 48:126–132.
Kendall SJH, Dyson M, McColl I (1992) The dose-dependent stimulation of human fibroblast migration by platelet-released factors in vitro. 2nd European Conference on Advances in Wound Management, Oct 20–23, Harrogate, UK.
Knighton DR, Hunt TK, Thakral KK, Goodson WH (1982) Role of platelets and fibrin in the healing sequence. An in vivo study of angiogenesis and collagen synthesis. Ann Surg 196(4):379–388.
Knighton DR, Fiegel VD, Ciresi KF (1986) Classification and treatment of chronic nonhealing wounds. Ann Surg 204(3):322–330.
Newman D, Marcone J (1991) Mitogenic response of different fibroblasts to platelet releasates and combinations of purified growth factors. 1st European Tissue Repair Society Meeting, Oxford.
Pierce GF, Mustoe TA, Deuel TF (1988) Transforming growth factor-β induces increased directed cellular migration and tissue repair in rats. In: Barbul A, Pines E, Caldwell M, Hunt TK (eds) Growth factors and other aspects of wound healing. Biological and clinical implications. Liss, New York, p 93.
Pierce GF, Yanagihara D, Costigan V, Tarpley J, Hockman H, Boone T, Song S-Z, Germain L, Klopchin K, Altrock BW, Thomason A (1991) Platelet-derived endothelial cell growth factor (PD-ECGF) in angiogenesis and wound healing (Abstr). 1st European Tissue Repair Society Meeting, Oxford.
Reiger GM, Hein R, Adelmann-Grill BC, Ruzicka, Krieg T (1990) Influence of eicosanoids on fibroblast chemotaxis and protein synthesis in vitro. J Dermatol Sci 1(5):347–354.
Senior RM, Griffin GL, Huang JS, Walz DA, Dueul TF (1983) Chemotactic activity of platelet α-granule proteins for fibroblasts. J Cell Biol 96:382–385.
Snowden JM, Kennedy DF, Cliff WJ (1982) Wound contraction. The effects of scab formation and the nature of the wound bed. Aust J Exp Biol Med Sci 60(1):73–82.
Spector WG, Willoughby DA (1959) Experimental suppression of acute inflammatory changes of thermal injury. J Pathol Bacteriol 78:121–132.
Van Winkle W (1967) Wound contraction. Surg Obstet Gynaecol 131-142.
Wahl SM (1985) Host immune factors regulating fibrosis. Ciba Found Symp 114:175.
Zawacki BE (1974) The natural history of reversible burn injury. Surg Gynaecol Obstet 139:867–872.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Kendall, S.J.H., Hart, J., Dyson, M., McColl, I. (1995). Platelet Released Factors Stimulate Rat Burn Wound Contraction. In: Altmeyer, P., Hoffmann, K., el Gammal, S., Hutchinson, J. (eds) Wound Healing and Skin Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77882-7_23
Download citation
DOI: https://doi.org/10.1007/978-3-642-77882-7_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-56124-8
Online ISBN: 978-3-642-77882-7
eBook Packages: Springer Book Archive