Skip to main content

Platelet Released Factors Stimulate Rat Burn Wound Contraction

  • Conference paper
Wound Healing and Skin Physiology
  • 546 Accesses

Abstract

After thermal injury fluctuations in blood platelet levels have been reported. Eurenius et al. (1972) found that when 30% full-thickness burn wounds were induced in rats, a thrombocytopenia occurred within the first few hours of injury followed by a thrombocythaemia which reached a maximum between 3–5 days. Similar blood platelet level fluctuations have been observed in humans, albeit with a more prolonged time course (Baxter 1974).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baumgartner HR, Muggli R, Tschopp TB (1980) Interaction of platelets with subendothelium in flowing blood. In: Rotman A, Meyer FA, Gitler C, Silberberg A (eds) Platelets. Cellular response mechanisms and their biological significance. Wiley, Chichester, p 17.

    Google Scholar 

  • Baxter CR (1974) Fluid volume and electrolyte changes of the early post burn period. Clin Plast Surg 1:693.

    PubMed  CAS  Google Scholar 

  • Boykin JV, Eriksson E, Pittman RN (1980) In vivo microcirculation of a scald burn and the progression of postburn dermal ischaemia. Plast Reconstr Surg 66(2): 191–198.

    Article  PubMed  CAS  Google Scholar 

  • Brown D, Garner W, Young LV (1990) Skin grafting: dermal components in inhibition of wound contraction. South Med J 83(7):789–795.

    Article  PubMed  CAS  Google Scholar 

  • Davidson J, Buckley A, Woodward S, Nichols W, McGee G, Demetriou A (1988) Mechanisms of accelerated wound repair using epidermal growth factor and basic fibroblast growth factor. In: Barbul A, Pines E, Caldwell M, Hunt TK (eds) Growth factors and other aspects of wound healing. Biological and clinical implications. Liss, New York, p 63.

    Google Scholar 

  • Ehrlich HP (1988) The role of connective tissue matrix in wound healing. In: Barbul A, Pines E, Caldwell M, Hunt TK (eds) Growth factors and other aspects of wound healing. Biological and clinical implications. Liss, New York, p 243.

    Google Scholar 

  • Eurenius K, Moretensen RF, Meserol PM, Curreri PW (1972) Platelet and megakaryocyte kinetics following thermal injury. J Lab Clin Med 79:247.

    PubMed  CAS  Google Scholar 

  • Gabbiani G, Ryan GB, Majno G (1971) Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experimentia 27:249.

    Article  Google Scholar 

  • Grotendorst GR, Grotendorst CA, Gilman T (1988) Production of growth factors (PDGF and TGF-β) at the site of tissue repair. In: Barbul A, Pines E, Caldwell M, Hunt TK (eds) Growth factors and other aspects of wound healing. Biological and clinical implications. Liss, New York, p 47.

    Google Scholar 

  • Holmsen H, Dangelmaier CA, Holmsen HK (1981) Thrombin-induced platelet responses differ in requirement for receptor occupancy. Evidence for tight coupling of occupancy and compartmentalised phosphatidic acid formation. J Biol Chem 256:9393–9396.

    PubMed  CAS  Google Scholar 

  • Johansson SA (1960) 5-hydroxytryptamine in burns. Acta Physiol Scand 48:126–132.

    Article  PubMed  CAS  Google Scholar 

  • Kendall SJH, Dyson M, McColl I (1992) The dose-dependent stimulation of human fibroblast migration by platelet-released factors in vitro. 2nd European Conference on Advances in Wound Management, Oct 20–23, Harrogate, UK.

    Google Scholar 

  • Knighton DR, Hunt TK, Thakral KK, Goodson WH (1982) Role of platelets and fibrin in the healing sequence. An in vivo study of angiogenesis and collagen synthesis. Ann Surg 196(4):379–388.

    Article  PubMed  CAS  Google Scholar 

  • Knighton DR, Fiegel VD, Ciresi KF (1986) Classification and treatment of chronic nonhealing wounds. Ann Surg 204(3):322–330.

    Article  PubMed  CAS  Google Scholar 

  • Newman D, Marcone J (1991) Mitogenic response of different fibroblasts to platelet releasates and combinations of purified growth factors. 1st European Tissue Repair Society Meeting, Oxford.

    Google Scholar 

  • Pierce GF, Mustoe TA, Deuel TF (1988) Transforming growth factor-β induces increased directed cellular migration and tissue repair in rats. In: Barbul A, Pines E, Caldwell M, Hunt TK (eds) Growth factors and other aspects of wound healing. Biological and clinical implications. Liss, New York, p 93.

    Google Scholar 

  • Pierce GF, Yanagihara D, Costigan V, Tarpley J, Hockman H, Boone T, Song S-Z, Germain L, Klopchin K, Altrock BW, Thomason A (1991) Platelet-derived endothelial cell growth factor (PD-ECGF) in angiogenesis and wound healing (Abstr). 1st European Tissue Repair Society Meeting, Oxford.

    Google Scholar 

  • Reiger GM, Hein R, Adelmann-Grill BC, Ruzicka, Krieg T (1990) Influence of eicosanoids on fibroblast chemotaxis and protein synthesis in vitro. J Dermatol Sci 1(5):347–354.

    Article  Google Scholar 

  • Senior RM, Griffin GL, Huang JS, Walz DA, Dueul TF (1983) Chemotactic activity of platelet α-granule proteins for fibroblasts. J Cell Biol 96:382–385.

    Article  PubMed  CAS  Google Scholar 

  • Snowden JM, Kennedy DF, Cliff WJ (1982) Wound contraction. The effects of scab formation and the nature of the wound bed. Aust J Exp Biol Med Sci 60(1):73–82.

    Article  PubMed  CAS  Google Scholar 

  • Spector WG, Willoughby DA (1959) Experimental suppression of acute inflammatory changes of thermal injury. J Pathol Bacteriol 78:121–132.

    Article  PubMed  CAS  Google Scholar 

  • Van Winkle W (1967) Wound contraction. Surg Obstet Gynaecol 131-142.

    Google Scholar 

  • Wahl SM (1985) Host immune factors regulating fibrosis. Ciba Found Symp 114:175.

    PubMed  CAS  Google Scholar 

  • Zawacki BE (1974) The natural history of reversible burn injury. Surg Gynaecol Obstet 139:867–872.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kendall, S.J.H., Hart, J., Dyson, M., McColl, I. (1995). Platelet Released Factors Stimulate Rat Burn Wound Contraction. In: Altmeyer, P., Hoffmann, K., el Gammal, S., Hutchinson, J. (eds) Wound Healing and Skin Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77882-7_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77882-7_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56124-8

  • Online ISBN: 978-3-642-77882-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics