Growth Factor Control of Wound Healing Angiogenesis
Angiogenesis is a fundamental biologic process which plays a pivotal role in development, pathologic states and physiologic responses. In the developing embryo, blood vessels form by two mechanisms: (1) vasculogenesis, in which mesoderm-derived angioblasts migrate to specific sites in the embryo and form a network of vascular cords, and (2) angiogenesis, which occurs primarily during organogenesis, and is characterized by the sprouting of new vessels from the established cords into previously avascular organ rudiments [1, 2]. Soluble angiogenesis factor or factors deposited in the extracellular matrix may act to stimulate and direct this neovascularization.
KeywordsPermeability Migration Depression Albumin Angiotensin
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