Abstract
Angiogenesis is a fundamental biologic process which plays a pivotal role in development, pathologic states and physiologic responses. In the developing embryo, blood vessels form by two mechanisms: (1) vasculogenesis, in which mesoderm-derived angioblasts migrate to specific sites in the embryo and form a network of vascular cords, and (2) angiogenesis, which occurs primarily during organogenesis, and is characterized by the sprouting of new vessels from the established cords into previously avascular organ rudiments [1, 2]. Soluble angiogenesis factor or factors deposited in the extracellular matrix may act to stimulate and direct this neovascularization.
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References
Poole TJ, Coffin JD (1989) Vasculogenesis and angiogenesis: two distinct morphogenetic mechanisms establish embryonic vascular pattern. J Exp Zool 251:224–231.
Risau W, Lemmon V (1988) Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Dev Biol 125:441–450.
Folkman J (1974) Tumor angiogenesis. Adv Cancer Res 10:331–358.
Moscatelli D, Joseph-Silverstein J, Presta M, Rifkin DB (1988) Multiple forms of an angiogenesis factor: basic fibroblast growth factor. Biochimie 70:83–87.
Baird A, Walicke PA (1989) Fibroblast growth factors. Br Med Bull 45:438–452.
Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT (1989) Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246:1309–1312.
Ziche M, Jones J, Gullino PM. (1982) Role of prostaglandin E1 and copper in angiogenesis. JNCI 69:475–482.
Weiss JB, Brown RA, Kumar S, Phillips P (1979) An angiogenic factor isolated from tumours. A potent low molecular weight compound. Br J Cancer 40:493–496.
Fett JW, Strydom DJ, Lobb RR, Alderman EM, Bethune JL, Riordan JF, Vallee BL (1985) Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells. Biochemistry 24:5480–5486.
Redmer DA, Grazul AT, Kirsch JD, Reynolds LP (1988) Angiogenic activity of bovine corpora lutea at several stages of luteal development. J Reprod Ferti 82:627–634.
Gospodarowicz D, Thakral KK (1977) Production of a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum. Proc Natl Acad Sci, USA 75:847–851.
Reynolds LP, Millaway DS, Kirsch JD, Infeld JE, Redmer DA (1987) Angiogenic activity of placental tissues of cows. J Reprod Ferti 81:233–240.
Reynolds LP, Reder DA (1988) Secretion of angiogenic activity by placental tissues of cows at several stages of gestation. J Reprod Ferti 83:497–502.
Burgos H (1986) Angiogenic factor from human term placenta. Purification and partial characterization. Eur J Clin Invest 16:486–493.
Moscatelli D, Presta M, Rifkin DB (1986) Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration. Proc Natl Acad Sci USA 83:2091–2095.
Phillips GD, Fiegel VD, Knighton DR (1992) Putative angiogenesis factors: A review. Wounds 4:94–107.
Ausprunk DH, Folkman J (1977) Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res 14:53–65.
Burger PC, Chandler DB, Klintworth GK (1983) Corneal neovascularization as studied by scanning electron microscopy of vascular casts. Lab Invest 48:169–180.
Burger PC, Chandler DB, Klintworth GK (1984) Scanning electron microscopy of vascular casts. J Electron Microsc Techn 1:341–348.
Phillips GD, Whitehead RA, Knighton DR (1991) Inititation and pattern of angiogenesis in wound healing in the rat. Am J Anat 192:257–262.
Knighton DR, Fiegel VD, Austin LL, Ciresi KF, Butler EL (1986) Classification and treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg 204:322–330.
Roberts A, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH, Fauci AS (1986) Transforming growth factor type B: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 83:4167–4171.
Gimbrone MA Jr, Cotran R, Leapman SB, Folkman J (1974) Tumor growth and neovas-cularization: an experimental model using the rabbit cornea JNCI 52:413–427.
Phillips GD, Whitehead RA, Stone AM, Ruebel MW, Goodkin ML, Knighton DR (1994) Transforming growth factor beta (TGF-β) stimulation of angiogenesis: an electron microscopic study. J Submicrosc Cytol Pathol 25:149–155.
Phillips GD, Whitehead RA, Knighton DR (1992) Inhibition by methylprednisolone acetate suggests an indirect mechanism for TGF-B induced angiogenesis. Growth Factors 6:77–84.
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© 1995 Springer-Verlag Berlin Heidelberg
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Knighton, D.R., Fiegel, V.D., Phillips, G.D. (1995). Growth Factor Control of Wound Healing Angiogenesis. In: Altmeyer, P., Hoffmann, K., el Gammal, S., Hutchinson, J. (eds) Wound Healing and Skin Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77882-7_13
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DOI: https://doi.org/10.1007/978-3-642-77882-7_13
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