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Growth Factor Control of Wound Healing Angiogenesis

  • D. R. Knighton
  • V. D. Fiegel
  • G. D. Phillips

Abstract

Angiogenesis is a fundamental biologic process which plays a pivotal role in development, pathologic states and physiologic responses. In the developing embryo, blood vessels form by two mechanisms: (1) vasculogenesis, in which mesoderm-derived angioblasts migrate to specific sites in the embryo and form a network of vascular cords, and (2) angiogenesis, which occurs primarily during organogenesis, and is characterized by the sprouting of new vessels from the established cords into previously avascular organ rudiments [1, 2]. Soluble angiogenesis factor or factors deposited in the extracellular matrix may act to stimulate and direct this neovascularization.

Keywords

Corpus Luteum Capillary Endothelial Cell Corneal Neovascularization Angiogenesis Factor Vascular Permeability Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • D. R. Knighton
    • 1
  • V. D. Fiegel
    • 1
  • G. D. Phillips
    • 1
  1. 1.Institute for Reparative Medicine and Embro CorporationSt. Louis ParkUSA

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