Skip to main content
SpringerLink
Log in

Multiple Thrombosen und Kumarin-induzierte Hautnekrosen bei einem Kind mit Antiphospholipid-Antikörpern: Effekt der Gabe von Prothrombin C-Konzentrat

  • Conference paper
22. Hämophilie-Symposion Hamburg 1991

  • 18 Accesses

Zusammenfassung

Das „Antiphospholipid-Syndrom“wurde bislang im Kindesalter sehr selten berichtet. Wir beschreiben ein 310hi Jahre altes, ansonsten gesundes Mädchen mit vorübergehenden Antiphospholipid-Antikörpern, einer vorübergehenden Störung der Protein C-Aktivierung, multiplen Thrombosen und Kumarin-induzier- ten Hautnekrosen. Keine anderen Veränderungen der Hämostase, die zu einer Thrombose prädisponieren könnten, konnten nachgewiesen werden und ebenso konnten keine anderen Autoimmunphänomene identifiziert werden. Die Gabe von Protein C-Konzentrat schien einen günstigen Effekt bei dieser Patientin zu haben, um die Ausdehnung der Kumarin-induzierten Hautnekrosen zu verringern und das neuerliche Auftreten solcher Nekrosen beim zweiten Versuch der oralen Antikoagulation zu verhindern.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Alegre VA, Winkelmann RK (1988) Histopathologic and immunofluorescence study of skin lesions associated with circulating lupus anticoagulant. J Am Acad Dermatol 19:117–124

    Article  PubMed  CAS  Google Scholar 

  2. Al-Saeed A, Malia RG, Makris M, Cooper S, Preston FE, Greaves M (1991) The development of antiphospholipid antibodies (APA) in haemophilia is strongly linked to infection with hepatitis C. Thromb Haemostas 65:1257 a

    Google Scholar 

  3. Amer L, Kisiel W, Searles RP, Williams RC (1990) Impairment of the protein C anticoagulant pathway in a patient with systemic lupus erythematosus, anticardiolipin antibodies and thrombosis. Thromb Res 57:247–258

    Article  PubMed  CAS  Google Scholar 

  4. Asherson RA (1988) A “primary” antiphospholipid syndrome. J Rheumatol 15:1742–1746

    PubMed  CAS  Google Scholar 

  5. Bernstein ML, Salusinsky-Sternbach M, Bellefleur M, Esseltine DW (1984) Thrombotic and hemorrhagic complications in children with the lupus anticoagulant. Am J Dis Child 138:1132–1135

    PubMed  CAS  Google Scholar 

  6. Cameron J St, Frampton G (1990) The “antiphospholipid syndrome” and the “lupus anticoagulant”. Pediatr Nephrol 4:663–678

    Article  Google Scholar 

  7. Carreras LO, Vermylen JG (1982) “Lupus” anticoagulant and thrombosis: possible role of inhibition of prostacyclin formation. Thromb Haemostas 48:28–40

    Google Scholar 

  8. Comp PC, De Bault LE, Esmon NL, Esmon CT (1983) Human thrombomodulin is inhibited by IgG from two patients with nonspecific anticoagulants. Blood 62:299 a

    Google Scholar 

  9. Dodd HJ, Sarkany I, O’Shaughnessy D (1985) Widespread cutaneous necrosis associated with the lupus anticoagulant. Clin Exp Dermat 10:581–586

    Article  CAS  Google Scholar 

  10. Feinstein DI (1985) Lupus anticoagulant, thrombosis, and fetal loss. New Engl J Med 21:1349

    Google Scholar 

  11. Frampton G, Perl S, Bennett A, Camerons JS (1986) Platelet associated DNA and anti- DNA antibody in systemic lupus erythematosus with nephritis. Clin Exp Immunol 63:621–628

    PubMed  CAS  Google Scholar 

  12. Girault C, Gufflet V, Robert A (1991) Tfie effect of lupus anticoagulant (LA) on clotting assay for plasma protein C (PC) Thromb Haemostas 66:389 (letter)

    CAS  Google Scholar 

  13. Grob JJ, Bonerandi JJ, Marseille F (1986) Cutaneous manifestations associated with the presence of the lupus anticoagulant. J Amer Acad Dermat 15:211–219

    Article  CAS  Google Scholar 

  14. Haire WD, Newland JR (1990) Protein C deficiency and anticardiolipin antibodies in a family with premature stroke. Am J Hemat 33:61–63

    Article  PubMed  CAS  Google Scholar 

  15. Le Roux G, Wautier MP, Guillevin L, Wautier JL (1986) IgG binding to endothelial cells in systemic lupus erythematosus. Thromb Haemost 56:144–146

    PubMed  Google Scholar 

  16. Madden RM, Gill JC, Marlar RA (1990) Protein C and protein S levels in two patients with acquired purpura fulminans. Br J Haematol 75:112–117

    Article  PubMed  CAS  Google Scholar 

  17. Palareti G, Legnani C, Ludovici S, Boggian O, Coccheri S (1991) Prevalence of high levels of antiphospholipid antibodies in other unexplained juvenile venous thromboembolism. Thromb Haemostas 65:452–453

    CAS  Google Scholar 

  18. Pelkonen P, Simell O, Rast V, Vaarala O (1988) Venous thrombosis associated with lupus anticoagulant and anticardiolipin antibodies. Acta Paediatr Scand 77:767–772

    Article  PubMed  CAS  Google Scholar 

  19. Ravelli A, Caporali R, Bianchi E, Viola S, Solm M, Montecucco C, Martini A (1990) Anticardiolipin syndrome in childhood: a report of two cases. Clin Exp Rheumat 8:95–98

    CAS  Google Scholar 

  20. Schwarz HP, Schramm W, Dreyfus M (1990) Monoclonal antibody purified protein C concentrate: initial clinical experience. In: Bruley DF, Drohan W (eds.): Protein C and related anticoagulants. Houston: Gulf Publishing, pp 83–88

    Google Scholar 

  21. St. Clair W, Jones BM, Rogers JS, Crouch M, Hrabovsky E (1981) Deep venous thrombosis and a circulating anticoagulant in systemic lupus erythematosus. Am J Dis Child 135:230–232

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Wien, Graz, Austria

    W. Muntean, K. Finding, A. Gamillscheg & H. P. Schwarz

Authors
  1. W. Muntean
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Finding
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Gamillscheg
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. P. Schwarz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Humberg, Deutschland

    G. Landbeck

  2. Abteilung für Angiologie, Universitätsklinikum, Theodor-Stern-Kai 7, 6000, Frankfurt am Main 70, Deutschland

    Inge Scharrer

  3. Hämostaseologische Abteilung Med. Klinik Innenstadt, Ziemssenstraße 1, 8000, München 2, Deutschland

    Wolfgang Schramm

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Muntean, W., Finding, K., Gamillscheg, A., Schwarz, H.P. (1992). Multiple Thrombosen und Kumarin-induzierte Hautnekrosen bei einem Kind mit Antiphospholipid-Antikörpern: Effekt der Gabe von Prothrombin C-Konzentrat. In: Landbeck, G., Scharrer, I., Schramm, W. (eds) 22. Hämophilie-Symposion Hamburg 1991. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77881-0_42

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77881-0_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56096-8

  • Online ISBN: 978-3-642-77881-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation