Multiple Thrombosen und Kumarin-induzierte Hautnekrosen bei einem Kind mit Antiphospholipid-Antikörpern: Effekt der Gabe von Prothrombin C-Konzentrat

  • W. Muntean
  • K. Finding
  • A. Gamillscheg
  • H. P. Schwarz
Conference paper

Zusammenfassung

Das „Antiphospholipid-Syndrom“wurde bislang im Kindesalter sehr selten berichtet. Wir beschreiben ein 310hi Jahre altes, ansonsten gesundes Mädchen mit vorübergehenden Antiphospholipid-Antikörpern, einer vorübergehenden Störung der Protein C-Aktivierung, multiplen Thrombosen und Kumarin-induzier- ten Hautnekrosen. Keine anderen Veränderungen der Hämostase, die zu einer Thrombose prädisponieren könnten, konnten nachgewiesen werden und ebenso konnten keine anderen Autoimmunphänomene identifiziert werden. Die Gabe von Protein C-Konzentrat schien einen günstigen Effekt bei dieser Patientin zu haben, um die Ausdehnung der Kumarin-induzierten Hautnekrosen zu verringern und das neuerliche Auftreten solcher Nekrosen beim zweiten Versuch der oralen Antikoagulation zu verhindern.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • W. Muntean
    • 1
  • K. Finding
    • 1
  • A. Gamillscheg
    • 1
  • H. P. Schwarz
    • 1
  1. 1.Wien, GrazAustria

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