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Membrane and Signal Transduction Targets

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New Approaches in Cancer Pharmacology: Drug Design and Development

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

Abstract

Recently, a torrent of biochemical and biological discoveries has more precisely begun to define the nature of the malignant phenotype. These findings present a formidable challenge to drug discovery teams. How can this knowledge be harnessed and the approach emulated? Sadly, the elegance and precision of some of the insights provided by molecular and cellular biologists have not yet been matched by the efforts of medicinal chemists and pharmacologists. It is both disappointing and frustrating that the anticancer drugs showing clinical promise in 1991 are still crude cell poisons, not dissimilar from those which exist in the current pharmacopoeia. How might progress be made?

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Authors and Affiliations

  1. The Cancer Research Campaign Molecular and Cellular Pharmacology Group, Department of Physiological Sciences, University of Manchester, Manchester, M13 9PT, UK

    John A. Hickman

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  1. John A. Hickman
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Editors and Affiliations

  1. Cancer Research Campaign Beatson Laboratories, CRC Department of Medical Oncology, University of Glasgow, Alexander Stone Building, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK

    Paul Workman (Chairman and Editor) (Chairman and Editor)

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© 1992 Springer-Verlag Berlin Heidelberg

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Hickman, J.A. (1992). Membrane and Signal Transduction Targets. In: Workman, P. (eds) New Approaches in Cancer Pharmacology: Drug Design and Development. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77874-2_5

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  • DOI: https://doi.org/10.1007/978-3-642-77874-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77876-6

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