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Der Einsatz von DNA Sonden und Oligonukleotiden in der pränatalen Diagnostik

  • U. Müller
Conference paper

Zusammenfassung

Bei der pränatalen Diagnostik sind invasive von nicht-invasiven Untersuchungen zu unterscheiden. Zu ersteren zählen Amniozentese, CVS (Chorionzottenbiopsie) und Fetoskopie, zu letzteren Ultraschalldiagnostik und Untersuchungen an maternalem Blut. Ziele der invasiven Techniken sind die direkte Untersuchung von Geweben des Embryos/Feten, die Analyse der Amnionflüssigkeit und die direkte Inspektion des Feten. Bei den nicht-invasiven Methoden steht die Ultraschalldiagnostik im Vordergrund. Biochemische Untersuchungen an maternalem Serum haben besonders während der letzten Jahre an Bedeutung gewonnen. Außerdem werden in jüngster Zeit Analysen diskutiert, die den Nachweis von embryonalen /fetalen Zellen in der maternalen Zirkulation ermöglichen sollen.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • U. Müller
    • 1
  1. 1.Institut für Humangenetik der Justus-Liebig-Universität GießenGießenDeutschland

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