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Experimental Models of Injury in the Mammalian Yolk Sac

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The Human Yolk Sac and Yolk Sac Tumors

Abstract

It is a traditional but false notion that, in mammals, the yolk sac represents only a vestigial structure concerned with an early and fleeting period of hematopoiesis and protein synthesis. This notion is rapidly being dispelled though examination of the ultrastructural features of the yolk sac (Pinter et al. 1986a; Moore and Metcalf 1970). Furthermore, the inescapable prominence and structural complexity of the human yolk sac freely protruding into the exocelomic cavity at a time when the hemochorial placenta is still imperfectly constituted certainly defies the concept of a vestigial structure. The exocelomic cavity is destined to disappear as the amniotic cavity enlarges, but this process takes several months. In the meantime, the yolk sac may absorb products expelled into the exocelomic space. The rapid and total disappearance of the exocelomic fluid may be taken as an indication that the balance favors absorption over excretion. Additionally, demonstration of absorptive vesicles both in the mesothelial cells and endodermal cells of the human yolk sac strengthens the concept of the yolk sac having a functional role during normal and abnormal embryogenesis (Funaki and Mikamo 1983; Pedersen et al. 1964; Eriksson et al. 1983; Reece et al. 1989).

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Authors
  1. E. A. Reece
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  2. E. Pinter
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  3. F. Naftolin
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Editors and Affiliations

  1. Head of Department, University Hospital, E-18012, Granada, Spain

    Francisco F. Nogales (Professor of Pathology) (Professor of Pathology)

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© 1993 Springer-Verlag Berlin Heidelberg

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Reece, E.A., Pinter, E., Naftolin, F. (1993). Experimental Models of Injury in the Mammalian Yolk Sac. In: Nogales, F.F. (eds) The Human Yolk Sac and Yolk Sac Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77852-0_8

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  • DOI: https://doi.org/10.1007/978-3-642-77852-0_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77854-4

  • Online ISBN: 978-3-642-77852-0

  • eBook Packages: Springer Book Archive

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