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Pathology of Extragonadal Yolk Sac Tumors

  • Chapter
The Human Yolk Sac and Yolk Sac Tumors

Abstract

Although the vast majority of yolk sac tumors (YSTs) arise within the gonads, these tumors are also encountered in a wide variety of extragonadal sites (Table 16.1). Extragonadal YSTs most commonly occur in locations where other germ cell tumors are occasionally encountered, such as the sacrococcyx, the retroperitoneum, the mediastinum, and the brain. Tumors in these sites are believed to originate from germ cells that have been misplaced or arrested in their embryonic migration. An origin from somatic cells that have undergone aberrant differentiation is a possible histogenesis for YSTs that arise in less common sites (such as the endometrium, stomach, abdominal wall) where other germ cell tumors are absent or rare. A somatic origin is even more likely when a YST appears to arise from a nonneoplastic or neoplastic lesion of non-germ-cell origin, such as endometriosis or an otherwise typical gastric adenocarcinoma.

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  1. P. B. Clement
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  2. R. H. Young
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  1. Head of Department, University Hospital, E-18012, Granada, Spain

    Francisco F. Nogales (Professor of Pathology) (Professor of Pathology)

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Clement, P.B., Young, R.H. (1993). Pathology of Extragonadal Yolk Sac Tumors. In: Nogales, F.F. (eds) The Human Yolk Sac and Yolk Sac Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77852-0_16

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  • DOI: https://doi.org/10.1007/978-3-642-77852-0_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77854-4

  • Online ISBN: 978-3-642-77852-0

  • eBook Packages: Springer Book Archive

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