Skip to main content

Negative Symptome und therapeutische Strategien bei Schizophrenie

  • Conference paper
Schizophrenie — aktuelle Trends und Behandlungsstrategien
  • 20 Accesses

Zusammenfassung

Obwohl erst seit wenigen Jahren im Brennpunkt wissenschaftlichen Interesses, werden Negativsymptome schon lange beschrieben. Zwar besteht noch keine völlige Übereinkunft darüber, wer die erste Beschreibung negative Symptome lieferte, doch wird am häufigsten John Hughlings Jackson (1875) genannt, der sie vor mehr als 100 Jahren als primäres Defizit der Schizophrenie beschrieb. Er stellte zur Diskussion, daß negative Symptome auf eine primäre, nichtpathologische Läsion zurückgehen. Die Positivsymptomatik schizophrener Patienten beruhte seiner Ansicht nach auf einem Releasephänomen oder der Aufhebung einer Hemmung.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Andreasen NC (1982a) Negative symptoms in schizophrenia: definition and reliability. Arch Gen Psychiatry 39: 784–788

    PubMed  CAS  Google Scholar 

  • Andreasen NC (1982b) Negative versus positive schizophrenia: definition and validation. Arch Gen Psychiatry 39: 789–794

    PubMed  CAS  Google Scholar 

  • Andreasen NC (1983) The Scale for the Assessment of Negative Symptoms (SANS). University of Iowa, Iowa City

    Google Scholar 

  • Andreasen NC (1984) The Scale for the Assessment of Positive Symptoms (SAPS). University of Iowa, Iowa City

    Google Scholar 

  • Andreasen NC, Flaum M, Swayze VW, Tyrrell G, Arndt S (1990) Positive and negative symptoms in schizophrenia. A critical reappraisal. Arch Gen Psychiatry 47: 615–621

    Google Scholar 

  • Angrist B, Rotrosen J, Gershon S (1980) Differential effects of amphetamine and neuroleptics on negative versus symptoms in schizophrenia. Psychopharmacology 72: 17–19

    Article  PubMed  CAS  Google Scholar 

  • Arndt S, Alliger RJ, Andreasen NC (1991) The distinction of positive and negative symptoms: the failure of a two–dimensional model. Br J Psychiatry 158: 317–322

    Article  PubMed  CAS  Google Scholar 

  • Bleuler E (1950) Dementia praecox or the group of schicophreniacs. Translated by Zinkin J. International Universities Press, New York

    Google Scholar 

  • Breier A, Wolkowitz OM, Doran AR, Roy A, Boronow J, Hommer DW, Pickar D (1987) Neuroleptic responsivity of positive and negative symptoms in schizophrenia. Am J Psychiatry 144: 1549–1555

    PubMed  CAS  Google Scholar 

  • Carpender WT, Heinrichs DW, Alphs LD (1985) Treatment of negative symptoms. Schizophrenia Bull 11: 440–447

    Google Scholar 

  • Clark NL, Ray TS, Ragland RD (1963) Chlorpromazine in chronic schizophrenic women: rate of onset and rate of dissipation of drug effects. Psychosom Med 25: 212–217

    PubMed  CAS  Google Scholar 

  • Coryell WH, Kelly MW, Perry PJ, Miller DD (1990) Haloperidol plasma levels and acute clinical in schizophrenia. J Clin Psychopharmacol 10: 397–402

    Article  PubMed  CAS  Google Scholar 

  • Crow TJ (1980) Molecular pathology of schizophrenia; more than one disease process? Br Med J 280: 66–68

    Article  PubMed  CAS  Google Scholar 

  • Docherty JP, Van Kämmen DP, Siris SG et al. (1978) Stages of onset of schizophrenic psychosis. Am J Psychiatry 135: 420–426

    PubMed  CAS  Google Scholar 

  • Fischer-Cornelssen KA, Ferner UJ (1976) An example of european multicenter trials: multi-spectral analysis of clozapine. Psychopharmacol Bull 12: 34–39

    PubMed  CAS  Google Scholar 

  • Goldberg SC (1985) Negative and deficit symptoms in schizophrenia do respond to neuroleptics. Schizophr Bull 11: 453–456

    PubMed  CAS  Google Scholar 

  • Gur RE, Mozley PD, Resnick SM et al. (1991) Relations among clinical scales in schizophrenia. Am J Psychiatry 148: 472–478

    PubMed  CAS  Google Scholar 

  • Jackson JH (1875) On temporary mental disorders after epileptic paroxysms. West Riding Lunatic Asylum Medical Report 5: 105–129

    Google Scholar 

  • Johnstone EC, Crow TJ, Frith CD, Carney MWP, Price JS (1979) Mechanism of the antipsychotic effect in the treatment of acute schizophrenia. Lancet 1: 848–851

    Google Scholar 

  • Kane J, Honigfeld G, Singer J et al. (1988) Clozapine for the treatmentresistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry 45: 789–796

    Google Scholar 

  • Kraepelin E (1919) Dementia praecox and paraphrenia. Barclay RB (ed) Livingston, Edinburgh Marks RC, Luchins DJ (1990) Relationship between brain imaging findings in schizophrenia and psychopathology. A review of the literature relating to positive and negative symptoms. Mod Probl Pharmacopsychiatry 24: 89–123

    Google Scholar 

  • Meitzer HY (1991) Pharmacologic treatment of negative symptoms. In negative schizophrenic symptoms: pathophysiology and clinical implications. Greden JF, Tandon R (eds) American Psychiatric, Washington, DC Meitzer HY, Bastani B, Young Kwon K et al. (1989) A prospective study of clozapine in treatment–resistant schizophrenic patients; I. preliminary report. Psychopharmacology 99: S68–S72

    Google Scholar 

  • Meitzer HY, Sommers AA, Luchins DJ (1986) The effect of neuroleptics and other psychotropic drugs on negative symptoms in schizophrenia. J Clin Psychopharmacol 6: 329–338

    Article  Google Scholar 

  • Naber D, Albus M, Burke H et al. (1985) Neuroleptic withdrawal in chronic schizophrenia: clinical and endocrine variables relating to psychopathology. Psychiatry Res 16: 207–219

    Article  PubMed  CAS  Google Scholar 

  • Serafatinides EA, Collins S, Clark MI (1972) Haloperidol, clopenthixol and chlorpromazine in chronic schizophrenia. J Nerv Ment Dis 154: 31–42

    Article  Google Scholar 

  • Siris SG, Morgan V, Fagerstrom R et al. (1987) Adjunctive imipramine in the treatment of postpsychotic depression. Arch Gen Psychiatry 44: 533–539

    PubMed  CAS  Google Scholar 

  • Tandon R, Goldman RS, Goodson J, Greden JF (1990) Mutability and relationship between positive and negative symptoms during neuroleptic treatment in schizophrenia. Biol Psychioatry 27: 1323–1326

    Article  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Miller, D. (1992). Negative Symptome und therapeutische Strategien bei Schizophrenie. In: Rifkin, A., Osterheider, M. (eds) Schizophrenie — aktuelle Trends und Behandlungsstrategien. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77843-8_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77843-8_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56014-2

  • Online ISBN: 978-3-642-77843-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics