Contribution of Diagnostic Imaging to Pathological Characterization of Focal Liver Lesions

  • R. Lencioni
  • P. Bagnolesi
  • A. Cilotti
  • D. Caramella
  • C. Bartolozzi
Conference paper


At the present time, fine-needle biopsy (FNB) is used routinely in the diagnostic management of focal liver lesions (Bret et al. 1986; Smith 1991). This technique has indeed proved to have a high diagnostic accuracy in the detection of malignancy (Buscarini et al. 1990). Sometimes, however, the definite pathological type of the lesion is hard to determine due to the extremely thin bioptic specimens obtained by means of fine needles. The purpose of this study was to establish whether diagnostic imaging can effectively aid the pathologist in characterizing liver tumors through FNB.


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  1. Bret PM, Fond A, Casola G et al. (1986) Abdominal lesions: a prospective study of clinical efficacy of percutaneous fine-needle biopsy. Radiology 159:345–346PubMedGoogle Scholar
  2. Buscarini L, Fornari F, Bolondi L et al. (1990) Ultrasound-guided fine-needle biopsy of focal liver lesions: techniques, diagnostic accuracy and complications. A retrospective study on 2091 biopsies. J Hepatol 11:344–348PubMedCrossRefGoogle Scholar
  3. Charboneau JW, Reading CC, Welch TJ (1990) CT and sonographically-guided needle biopsy: current techniques and new innovations. Am J Roentgenol 154:1–10Google Scholar
  4. Dooms GC, Kerlan RK, Hricak H et al. (1986) Cholangiocarcinoma: imaging by MR. Radiology 159:89–94PubMedGoogle Scholar
  5. Kerlin P, Davis GL, McGill DB et al. (1983) Hepatic adenoma and focal nodular hyperplasia: clinical, pathologic and radiologic features. Gastroenterology 84:994–1002PubMedGoogle Scholar
  6. Ishak KG, Rabin L (1975) Benign tumors of the liver. Med Clin North Am 59:995–1013PubMedGoogle Scholar
  7. Limberg B, Hopker WW, Kommerel B (1987) Histologic differential diagnosis of focal liver lesions by ultrasonically-guided fine-needle biopsy. Gut 28:237–241PubMedCrossRefGoogle Scholar
  8. Mathieu D, Bruneton JN, Drouillard J et al. (1986) Hepatic adenomas and focal nodular hyperplasia: dynamic CT study. Radiology 160:53–58PubMedGoogle Scholar
  9. Mattison GR, Glazer GM, Quint LE et al. (1987) MR imaging of hepatic focal nodular hyperplasia: characterization and distinction from primary malignant hepatic tumors. Am J Roentgenol 148:711–715Google Scholar
  10. O’Neil J, Ros PR (1989) Knowing hepatic pathologic aids MRI of liver tumors. Diagn Imaging 11,12:58–65Google Scholar
  11. Reading CC, Charboneau JW, James EM et al. (1988) Sonographically-guided percutaneous biopsy of small (3 cm or less) masses. Am J Roentgenol 151:189–192Google Scholar
  12. Ros PR, Buck JL, Goodman ZD et al. (1988) Intrahepatic cholangiocarcinoma: radiologic-pathologic correlation. Radiology 167:689–693PubMedGoogle Scholar
  13. Rummeny E, Weissleder R, Stark DD et al. (1989) Primary liver tumors: diagnosis by MR imaging. Am J Roentgenol 152:63–72Google Scholar
  14. Sangalli G, Livraghi T, Giordano F (1989) Fine-needle biopsy of hepatocellular carcinoma: improvement in diagnosis by microhistology. Gastroenterology 96:524–526PubMedGoogle Scholar
  15. Scott Gazelle G, Haaga J (1989) Guided percutaneous biopsy of intraabdominal lesions. Am J Roentgenol 153:929–935Google Scholar
  16. Smith EH (1991) Complications of percutaneous abdominal fine-needle biopsy. Radiology 178:253–258PubMedGoogle Scholar
  17. Spamer C, Brambs HJ, Kock HK et al. (1986) Benign circumscribed lesions of the liver diagnosed by ultrasonically guided fine-needle biopsy. JCU 14:83–88PubMedGoogle Scholar
  18. Welch TJ, Sheedy PP, Johnson CM et al. (1985) Focal nodular hyperplasia and hepatic adenoma: comparison of angiography, CT, US and scintigraphy. Radiology 156:593–595PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • R. Lencioni
  • P. Bagnolesi
  • A. Cilotti
  • D. Caramella
  • C. Bartolozzi

There are no affiliations available

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