Physiological Principles for the Design of Hepatic Contrast Agents

  • D. D. Stark
Conference paper


The general requirements for design of a clinically useful contrast agent for magnetic resonance imaging (MRI) are: (a) magnetic activity which alters image signal intensity; (b) biodistribution to normal tissue and exclusion by diseased tissue (or the reverse); and (c) low toxicity or a high margin of safety for the effective dose.


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© Springer-Verlag Berlin Heidelberg 1993

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  • D. D. Stark

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