Re-epithelialization of Incision and Burn Wounds in Culture

  • J. Bereiter-Hahn
  • M. Vöth


Sheets of epidermal cells emigrated from tadpoles of Xenopus laevis retain their in situ relationship of basal and surface cells. These cellular sheets have been used to compare the process of primary closure of wounds made either by incision with a scalpel or by UV irradiation. In the latter case, no response of the cells surrounding the killed epidermis is observed. After mechanical injury, retraction of the wound margins followed by extension of lamellae and subsequent migration of the marginal cells immediately initiates wound closure. We conclude that mechanical interactions of the intact cells with those being killed by irradiation prevents the sequence of reactions taking place in incision wounds.


Epidermal Cell Xenopus Laevis Wound Closure Incision Wound Marginal Cell 
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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. Bereiter-Hahn
  • M. Vöth

There are no affiliations available

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