Peptidergic Regulation of Smooth Muscle Contractility

  • J. R. Grider
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 106)


The main functions of the smooth muscle of the gut are to mix and propel intraluminal contents in a coordinated manner in order to facilitate the digestion and absorption of nutrients and expulsion of unabsorbed residue. These functions are determined by intrinsic electrical and mechanical properties of the muscle and their regulation by hormones and neurotransmitters. The myenteric plexus, one of the two main components of the enteric nervous system, is particularly important in the regulation of smooth muscle activity. This chapter will discuss peptide hormones and transmitters that are important in the regulation of smooth muscle activity in the gut.


Vasoactive Intestinal Peptide Vasoactive Intestinal Polypeptide Myenteric Plexus Smooth Muscle Contractility Submucosal Plexus 
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© Springer-Verlag Berlin Heidelberg 1993

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  • J. R. Grider

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