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Gastrointestinal Regulatory Peptides pp 253–276Cite as

Peptides and Enteric Neural Activity

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 106))

Abstract

There have been many advances in recent years in our understanding of the neurophysiology and neurochemistry of enteric neurons. The mechanisms by which neurotransmitters, including some peptides, affect gastrointestinal (GI) function have, in some cases, been described in great detail. There is a large number of peptides contained in and released from enteric nerves and endocrine cells in the GI tract and the localization and characterization of these peptides and their precursors are the subjects of other chapters in this volume. This chapter will focus on the actions of GI peptides on single neurons found in the intramural plexuses of the GI tract, including nerve cells in the gall bladder and pancreas. The focus will be on the receptors present on neurons, the ionic mechanisms by which peptides alter neuronal activity and the transduction systems, if known, by which peptide receptors are coupled to ion channels in enteric nerves.

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  1. J. J. Galligan
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  1. Department of Veterinary Biology, Pharmacology Section, University of Minnesota, 1988 Fitch Avenue, Saint Paul, MN, 55108, USA

    David R. Brown Ph.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Galligan, J.J. (1993). Peptides and Enteric Neural Activity. In: Brown, D.R. (eds) Gastrointestinal Regulatory Peptides. Handbook of Experimental Pharmacology, vol 106. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77814-8_8

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  • DOI: https://doi.org/10.1007/978-3-642-77814-8_8

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