Proteolytic Inactivation of Neurohormonal Peptides in the Gastrointestinal Tract
The gastrointestinal tract is a major site of production and inactivation of neurohormonal peptides. While biochemical and morphological aspects of the synthesis of gastrointestinal peptides have been studied in detail, relatively little work has been done to investigate the mechanisms by which these peptides are degraded following release. The neurohormonal peptides discussed in this article have different cellular distributions both along and within the different layers of the stomach and gut. Consequently, an analysis of the mechanisms by which these peptides are inactivated must take into account the microenvironment into which they are released.
KeywordsHydrolysis Proline Polypeptide Angiotensin Leucine
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