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Peptide Receptors and Signal Transduction in the Digestive Tract

  • Chapter
Gastrointestinal Regulatory Peptides

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 106))

Abstract

The digestive tract is equipped with a diffuse endocrine tissue which synthesizes and releases a variety of peptide hormones. It is also richly innervated by extrinsic and intrinsic neurons which store many neuropeptides and classical neurotransmitters (see Chap. 1). Since the discovery of the first hormone in intestine, i.e., secretin (Bayliss and Starling 1902), the digestive tract has been a major source for the discovery and isolation of new regulatory peptides (McDonald 1991a,b). They have been identified thereafter in many other tissues, in particular the central nervous system, giving rise to the so-called brain-gut axis concept (McDonald 1991a,b). The reverse is also true since peptides initially discovered in brain have been thereafter characterized in the gut.

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Authors
  1. M. Laburthe
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  2. P. Kitabgi
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  3. A. Couvineau
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  4. B. Amiranoff
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Editors and Affiliations

  1. Department of Veterinary Biology, Pharmacology Section, University of Minnesota, 1988 Fitch Avenue, Saint Paul, MN, 55108, USA

    David R. Brown Ph.D.

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Laburthe, M., Kitabgi, P., Couvineau, A., Amiranoff, B. (1993). Peptide Receptors and Signal Transduction in the Digestive Tract. In: Brown, D.R. (eds) Gastrointestinal Regulatory Peptides. Handbook of Experimental Pharmacology, vol 106. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77814-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-77814-8_5

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