Peptidergic Regulation of Gastrointestinal Blood Flow

  • C. C. Chou
  • A. Alemayehu
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 106)


Gastrointestinal (GI) peptides can increase or decrease blood flow in addition to their actions on digestive functions, such as GI motility, intestinal absorption, and gastric and pancreatic secretions. Their vasoactive potency (i.e., the dose required to produce vasoactivity) may differ from their potency to induce changes in digestive functions and, therefore, the respective potencies should be compared. The relative potency of some chemicals on GI motility and blood flow, and the relationship between these two variables, have been summarized (Chou 1989). Administration of a peptide often produces concomitant changes in a digestive function, local oxidative metabolism, and local blood flow. A change in the tissue activity and metabolism can cause changes in local blood flow, and a change in blood flow can influence tissue activity. One should determine which aspect is the cause and which is the result. Another issue to be considered is whether or not the digestive and vascular actions of a peptide are physiological. Physiologically, the GI peptides are released following a meal to regulate digestive functions and local blood flow. In order to be a physiological peptide, the postprandial tissue or blood concentrations must be sufficient to produce vasoactivity. This topic has been discussed previously by comparing the minimal local blood concentration required to produce vasodilation with that achieved following a meal (Chou and Kvietys 1981; Chou et al. 1984).


Vasoactive Intestinal Polypeptide Gastric Inhibitory Polypeptide Mucosal Blood Flow Local Blood Flow Gastric Mucosal Blood Flow 
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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • C. C. Chou
  • A. Alemayehu

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