Skip to main content
SpringerLink
Log in

Peptidergic Regulation of Intestinal Electrolyte Transport

  • Chapter
Gastrointestinal Regulatory Peptides

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 106))

  • 72 Accesses

Abstract

The intestinal epithelium plays an essential role in the control of extracellular fluid volume, electrolyte composition and acid-base balance in vertebrate animals(Powell 1987; Halm and Frizzell1991). Active transport of monovalent ions across the epithelium establishes an osmotic driving force for the absorption or secretion of fluid (Finkelstein 1987; Spring 1991). Many studies have shown that the transport pathways involved in net electrolyte movements are regulated by neuropeptides and peptide hormones (Brown and Miller1991). Much of our understanding of the second messenger systems and epithelial transport pathways affected by these peptides is incomplete. This is particularly true for mammalian intestine and colon due to the variety of cell types within the epithelium and to secondary effects of peptide neurohormones on submucosal nerves, resident leukocytes, and enteroendocrine cells. The first objective of this review is to provide a general overview of the mechanisms of sodium (Na+), potassium (K+), chloride (Cl-) and bicarbonate (HCO -3 ) transport across the small intestine and colon. More detailed reviews of intestinal and colonic ion transport can be found in the following references (Powell 1987; Donowitz and Welsh 1987; Sullivan and Field 1991; Halm and Frizzell 1991).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahn J, Chang EB, Field M (1985) Phorbol ester inhibition of Na-H exchange in rabbit proximal colon. Am J Physiol 249:C527–C530

    PubMed  CAS  Google Scholar 

  • Albin D, Gutman Y (1979) Tritiated ouabain binding and dissociation in rabbit colon: effects of ions and drugs. Biochem Pharmacol 28:3181–3188

    Article  PubMed  CAS  Google Scholar 

  • Allen JM, Hughes J, Bloom SR (1987) Presence, distribution and pharmacological effects neuropeptide Y in mammalian gastrointestinal tract. Dig Dis Sci 32:506–512

    Article  PubMed  CAS  Google Scholar 

  • Amar S, Kitabgi P, Vincent JP (1986) Activation of phosphoinositol turnover by neurotensin receptors in the human colonic adenocarcinoma cell line HT29. FEBS Lett 201:31–36

    Article  PubMed  CAS  Google Scholar 

  • Barbezat GO (1973) Stimulation of intestinal secretion by peptide hormones. Scand J Gastroenterology 8:3–21

    Google Scholar 

  • Barbezat GO, Reasbeck PG (1983) Effects of bombesin, calcitonin and enkephalin on canine jejenual water and electrolyte transport. Dig Dis Sci 28:273–277

    Article  PubMed  CAS  Google Scholar 

  • Barros F, Dominguez P, Velasco G, Lazo PS (1986) Na/H exchange is present in the basolateral membranes from rabbit small intestine. Biochem Biophys Res Commun 134:827–834

    Article  PubMed  CAS  Google Scholar 

  • Berschneider HM, Martens H, Powell DW (1988) Effect of BW942C, an enkephalin-like pentapeptide, on sodium and chloride transport in the rabbit ileum. Gastroenterology 94:127–136

    PubMed  CAS  Google Scholar 

  • Binder HJ (1978) Sodium and chloride transport across colonic mucosa in the rat. In: Hoffman JF (ed) Membrane transport processes. Raven, New York, p 309

    Google Scholar 

  • Binder HJ, Laurenson JP, Dobbins JW (1984) Role of opiate receptors in the regulation of enkephalin stimulation of active sodium and chloride absorption. Am J Physiol 247:G432–G436

    PubMed  CAS  Google Scholar 

  • Bolton JE, Munday KA, Parsons BJ, York BG (1975) Effects of angiotensin II on fluid transport, transmural potential difference and blood flow by rat jejunum in vivo. J Physiol (Lond) 253:411–428

    CAS  Google Scholar 

  • Bridges RJ, Nell G, Rummel W (1983) Influence of vasopressin and calcium on electrolyte transport across isolated colonic mucosa of the rat. J Physiol (Lond) 338:463–475

    CAS  Google Scholar 

  • Bridges RJ, Rummel W, Wallenberg P (1984) Effects of vasopressin on electrolyte transport across isolated colon from normal and dexamethasone-treated rats. J Physiol (Lond) 355:11–23

    CAS  Google Scholar 

  • Brown DR (1987) Intracellular mediators of peptide action in the intestine and airways: focus on ion transport function. Am Rev Respir Dis 136:S43–S48

    Article  PubMed  CAS  Google Scholar 

  • Brown DR, Miller RJ (1991) Neurohormonal control of fluid and electrolyte transport in intestinal mucosa. In: Schultz SG, Field M, Frizzell RA (eds) Intestinal absorption and secretion. The gastrointestinal system IV. American Physiological Society, Bethesda MD, p 527 (Handbook of physiology, Sect. 6)

    Google Scholar 

  • Brown DR, Quito FL (1988) Neuromedin U octapeptide alters ion transport in porcine jejunum. Eur J Pharmacol 155:159–162

    Article  PubMed  CAS  Google Scholar 

  • Brown DR, Treder BG (1989) Neurohumoral regulation of ion transport in the porcine distal jejunum. Actions of neurotensin and its natural homologs. J Pharmacol Exp Ther 249:348–357

    PubMed  CAS  Google Scholar 

  • Brown DR, Boster SL, Overend MF, Parsons AM, Treder BG (1990a) Actions of neuropeptide Y on basal, cyclic AMP-induced and neurally evoked ion transport in porcine distal jejunum. Regul Pept 29:31–47

    Article  PubMed  CAS  Google Scholar 

  • Brown DR, Overend MF, Treder BG (1990b) Neurohormonal regulation of ion transport in the porcine distal jejunum. Actions of somatostatin-14 and its natural and synthetic homologs. J Pharmacol Exp Ther 252:126–134

    PubMed  CAS  Google Scholar 

  • Brown DR, Hildebrand KR, Parsons AM, Soldani G (1990c) Effects of galanin on smooth muscle and mucosa of porcine jejunum. Peptides 11:497–500

    Article  PubMed  CAS  Google Scholar 

  • Brown DR, Parsons AM, O’Grady SM (1992) Substance P produced sodium and bicarbonate secretion in porcine jejunal mucosa through an action on enteric neurons. J Pharmacol Exp Ther 261:1206–1212

    PubMed  CAS  Google Scholar 

  • Buchan AMJ, Sikora KJ, Levy JG, Mcintosh CHS (1985) An immunocytochemical investigation with monoclonal antibodies to somatostatin. Histochemistry 83:175–180

    Article  PubMed  CAS  Google Scholar 

  • Carraway RE, Ferris CF (1983) Isolation, biological and chemical characterization and synthesis of a neurotensin-related hexapeptide from chicken intestine. J Biol Chem 258:2475–2479

    PubMed  CAS  Google Scholar 

  • Cassano G, Stieger B, Murer H (1984) Na/H and Cl/HCO3 exchange in rat jejunal and rat proximal tubular brush border membrane vesicles. Studies with acridine orange. Pflugers Arch 400:309–317

    Article  PubMed  CAS  Google Scholar 

  • Chandan R, Newell S, Brown DR (1988) Actions of gastrin-releasing peptide and related mammalian and amphibian peptides on ion transport in the porcine proximal jejunum. Regul Pept 23:1–14

    Article  PubMed  CAS  Google Scholar 

  • Chandan R, Hildebrand KR, Seybold VS, Soldani G, Brown DR (1991) Cholinergic neurons and muscarinic receptors mediate anion secretion in pig distal jejunum. Eur J Pharmacol 193:265–273

    Article  PubMed  CAS  Google Scholar 

  • Chang EB, Musch MW (1990) Calcium mediated neurohumoral inhibition of chicken enterocyte Na influx: role of phosphatidylinositol metabolites. Life Sci 46:1913–1921

    Article  PubMed  CAS  Google Scholar 

  • Chang EB, Brown DR, Wang NS, Field M (1986) Secretagogue-induced changes in membrane calcium permeability in chicken and chinchilla ileal mucosa: selective inhibition by loperamide. J Clin Invest 78:281–287

    Article  PubMed  CAS  Google Scholar 

  • Chang EB, Musch MW, Mayer L (1990) Interleukins 1 and 3 stimulate anion secretion in chicken intestine. Gastroenterology 98:1518–1524

    Article  PubMed  CAS  Google Scholar 

  • Cliff WH, Frizzell RA (1990) Separate Cl conductances activated by cAMP and Ca in Cl secreting epithelial cells. Proc Natl Acad Sci USA 87:4956–4960

    Article  PubMed  CAS  Google Scholar 

  • Cohn J (1987) Vasoactive intestinal peptide stimulates protein phosphorylation in a colonic epithelial cell line. Am J Physiol 253:G420–G424

    PubMed  CAS  Google Scholar 

  • Coupar IM (1983) Characterization of the opiate receptor population mediating inhibition of VIP-induced secretion from the small intestine of the rat. Br J Pharmacol 80:371–376

    PubMed  CAS  Google Scholar 

  • Coupar IM (1986) Tetrodotoxin inhibits directly acting stimulants of intestinal fluid secretion. J Pharm Pharmacol 38:553–555

    Article  PubMed  CAS  Google Scholar 

  • Cox HM, Cuthbert AW, Munday KA (1987) The effect of angiotensin II upon electrogenic ion transport in rat intestinal epithelia. Br J Pharmacol 90:393–401

    PubMed  CAS  Google Scholar 

  • Cox HM, Cuthbert AW, Hâkanson R, Wahlestedt C (1988) The effect of neuropeptide Y and peptide YY on electrogenic ion transport in rat intestinal epithelia. J Physiol (Lond) 398:65–80

    CAS  Google Scholar 

  • Crane MR, O’Hanley P, Waldman SA (1990) Rat intestinal cell atrial natriuretic peptide receptor coupled to guanylate cyclase. Gastroenterology 99:125–131

    PubMed  CAS  Google Scholar 

  • Daniel EE, Costa M, Furness JB, Keast JR (1985) Peptide neurons in the canine small intestine. J Comp Neurol 237:227–238

    Article  PubMed  CAS  Google Scholar 

  • Davies NT, Munday KA, Parsons BJ (1970) The effect of angiotensin on rat intestinal fluid transfer. J Endocrinol 48:39–46

    Article  PubMed  CAS  Google Scholar 

  • Davis GR, Camp RC, Raskin P, Krejs GJ (1980) Effect of somatostatin infusion on jejunal water and electrolyte transport in a patient with secretory diarrhea due to malignant carcinoid syndrome. Gastroenterology 78:346–349

    PubMed  CAS  Google Scholar 

  • Davis GR, Santa-Ana CA, Morawski SG, Fordtran JS (1981) Effect of vasoactive intestinal polypeptide on active and passive transport in the human jejunum. J Clin Invest 67:1687–1694

    Article  PubMed  CAS  Google Scholar 

  • Davis GR, Santa-Ana CA, Morawski SG, Fordtran JS (1982) Permeability characteristics of human jejunum, ileum, proximal colon and distal colon: results of potential difference measurements and unidirectional fluxes. Gastroenterology 83:844–850

    PubMed  CAS  Google Scholar 

  • Dawson DC (1991) Ion channels in colonic salt transport. Annu Rev Physiol 53:321–339

    Article  PubMed  CAS  Google Scholar 

  • Dharmsathaphorn K (1985) Intestinal somatostatin function. Adv Exp Biol Med 188:463–473

    CAS  Google Scholar 

  • Dharmsathaphorn K, Binder HJ, Dobbins JW (1980a) Somatostatin stimulates sodium and chloride absorption in the rabbit ileum. Gastroenterology 78:1559–1565

    PubMed  CAS  Google Scholar 

  • Dharmsathaphorn K, Racusen L, Dobbins JW (1980b) Effects of somatostatin on ion transport in the rat colon. J Clin Invest 66:813–820

    Article  PubMed  CAS  Google Scholar 

  • Dharmsathaphorn K, McRoberts JA, Mandel KG, Tisdale LD, Masui H (1984) A human colonic tumor cell line that maintains vectorial electrolyte transport. Am J Physiol 246:G204–G208

    PubMed  CAS  Google Scholar 

  • Dharmsathaphorn K, Mandel KG, Masui H, McRoberts JA (1985) Vasoactive intestinal polypeptide-induced Cl secretion by a colonic epithelial cell line: direct participation of a basolaterally localized Na-K-Cl cotransport system. J Clin Invest 75:462–471

    Article  PubMed  CAS  Google Scholar 

  • DiBona DR, Mills JW (1979) Distribution of Na pump sites in transporting epithelia. Fed Proc 38:134–143

    PubMed  CAS  Google Scholar 

  • Dobbins JW, Racusen L, Binder HJ (1980) Effect of D-alanine methionine enkephalin amide on ion transport in rabbit ileum. J Clin Invest 66:19–28

    Article  PubMed  CAS  Google Scholar 

  • Donowitz M, Welsh MJ (1987) Regulation of mammalian small intestinal electrolyte secretion. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, p 1351

    Google Scholar 

  • Donowitz M, Fogel R, Battisti L, Asarkof N (1982) The neurohumoral secretagogues carbachol, substance P and neurotensin increase Ca+2 influx and calcium content in rabbit ileum. Life Sci 31:1929–1937

    Article  PubMed  CAS  Google Scholar 

  • Duffey ME (1984) Intracellular pH and bicarbonate activities in rabbit colon. Am J Physiol 246:C558–C561

    PubMed  CAS  Google Scholar 

  • Erspamer V (1981) The tachykinin peptide family. Trends Neurosci 4:267–269

    Article  CAS  Google Scholar 

  • Fan CC, Faust RG, Powell DW (1983) Coupled sodium chloride transport by rabbit ileal brush border membrane vesicles. Am J Physiol 244:G375–G385

    PubMed  CAS  Google Scholar 

  • Field M (1971) Ion transport in rabbit ileal mucosa. II. Effects of cyclic 3′,5′-AMP. Am J Physiol 221:992–997

    PubMed  CAS  Google Scholar 

  • Finkelstein A (1987) Water movement through lipid bilayers, pores, and plasma membranes, vol 4. Wiley, New York

    Google Scholar 

  • Fogel R, Kaplan RB (1984) Role of enkephalins in regulation of basal intestinal water and ion absorption in the rat. Am J Physiol 246:G386–G392

    PubMed  CAS  Google Scholar 

  • Franklin CC, Turner JT, Kim HD (1989) Regulation of Na-K-Cl cotransport and [3H]bumetanide binding site density by phorbolesters in HT29 cells. J Biol Chem 264:6667–6673

    PubMed  CAS  Google Scholar 

  • Friel DD, Miller RJ, Walker MW (1986) Neuropeptide Y: a powerful modulator of epithelial ion transport. Br J Pharmacol 88:425–431

    PubMed  CAS  Google Scholar 

  • Garty H, Benos DJ (1988) Characteristics and regulatory mechanisms of the amiloride-blockable Na channel. Physiol Rev 68:309–373

    PubMed  CAS  Google Scholar 

  • Gerbes AL, Denecke H, Nathrath W (1990) Presence of atrial natriuretic factor prohormone in enterochromaffin cells of the human large intestine. Gastroenterology 98:A495

    Google Scholar 

  • Glynn IM, Karlish JD (1975) The sodium pump. Annu Rev Physiol 27:13–55

    Article  Google Scholar 

  • Grasset E, Bernabeu J, Pinto M (1985) Epithelial properties of human colonic carcinoma cell line Caco-2: effect of secretagogues. Am J Physiol 248:C410–C418

    PubMed  CAS  Google Scholar 

  • Grassl SM, Holohan PD, Ross CR (1987) HCO3 transport in basolateral membrane vesicles isolated from rat renal cortex. J Biol Chem 262:2682–2687

    PubMed  CAS  Google Scholar 

  • Guandalini S, Kachur JF, Smith PL, Miller RJ, Field M (1980) In vitro effects of somatostatin on ion transport in rabbit intestine. Am J Physiol 238:G67–G74

    PubMed  CAS  Google Scholar 

  • Gunther RD, Wright EM (1983) Na, Li, Cl transport by brush border membranes from rabbit jejunum. J Membr Biol 74:85–94

    Article  PubMed  CAS  Google Scholar 

  • Gustin MC, Goodman DBP (1981) Isolation of brush border membrane from rabbit descending colon epithelium: partial characterization of a unique potassium activated ATPase. J Biol Chem 256:10651–10656

    PubMed  CAS  Google Scholar 

  • Haas M (1989) Properties and diversity of (Na-K-Cl) cotransporters. Annu Rev Physiol 51:443–457

    Article  PubMed  CAS  Google Scholar 

  • Halm DR, Dawson DC (1984) Potassium transport by turtle colon: active secretion and active absorption. Am J Physiol 246:C315–C322

    PubMed  CAS  Google Scholar 

  • Halm DR, Frizzell JA (1986) Active K transport across rabbit distal colon: relation to Na absorption and Cl secretion. Am J Physiol 251:C252–C267

    PubMed  CAS  Google Scholar 

  • Halm DR, Frizzell RA (1991) Ion transport across the large intestine. In: Schultz SG, Field M, Frizzell RA (eds) The gastrointestinal system IV. American Physiological Society, New York, p 257 (Handbook of physiology)

    Google Scholar 

  • Hatch M, Freel RW, Goldner AM, Earnest DL (1984) Oxalate and chloride absorption by the rabbit colon: sensitivity to metabolic and anion transport inhibitors. Gut 25:232–237

    Article  PubMed  CAS  Google Scholar 

  • Heintze K, Petersen KU, Wood JR (1982) Effects of bicarbonate on fluid and electrolyte transport by guinea pig and rabbit gallbladder: stimulation of absorption. J Membr Biol 62:175–181

    Google Scholar 

  • Hopfer U (1987) Membrane transport mechanisms for hexoses and amino acids in the small intestine. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, p 1499

    Google Scholar 

  • Hopfer U, Liedtke CM (1987) Proton and bicarbonate transport mechanisms in the intestine. Annu Rev Physiol 49:51–67

    Article  PubMed  CAS  Google Scholar 

  • Hornych A, Meyer P, Milliez P (1973) Angiotensin, vasopressin and cyclic AMP: effects on sodium and water fluxes in rat colon. Am J Physiol 224:1223–1229

    PubMed  CAS  Google Scholar 

  • Hubel KA, Renquist KS (1986) The effect of neuropeptide Y on ion transport by the rabbit ileum. J Pharmacol Exp Ther 238:167–169

    PubMed  CAS  Google Scholar 

  • Hubel KA, Renquist KS, Shirazi S (1984) Neural control of ileal ion transport: role of substance P in rabbit and man. Gastroenterology 86:1118

    Google Scholar 

  • Humphreys MH (1976) Inhibition of Na and Cl absorption from perfused rat ileum by furosemide. Am J Physiol (Lond) 230:1571–1523

    Google Scholar 

  • Isenberg JI, Wallin B, Johansson C, Smedfors B, Mutt V, Tatemoto K, Emas S (1984) Secretin, VIP and PHI stimulate rat proximal duodenal surface epithelial bicarbonate secretion in vivo. Regul Pept 8:315–320

    Article  PubMed  CAS  Google Scholar 

  • Itoh S, Obata K, Yanaihara N, Okamoto H (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27 like peptide, PHM-27. Nature 304:547–549

    Article  PubMed  CAS  Google Scholar 

  • Kachur JF, Miller RJ, Field M, Rivier J (1982a) Neurohumoral control of ileal electrolyte transport. I. Bombesin and related peptides. J Pharmacol Exp Ther 220:449–455

    PubMed  CAS  Google Scholar 

  • Kachur JF, Miller RJ, Field M, Rivier J (1982b) Neurohumoral control of ileal electrolyte transport. II. Neurotensin and substance P. J Pharmacol Exp Ther 220:456–463

    PubMed  CAS  Google Scholar 

  • Kachur JF, Phillips GS, Gaginella TS (1991) Neuromodulation of guinea pig intestinal electrolyte transport by cholecystokinin octapeptide. Gastroenterology 100:344–349

    PubMed  CAS  Google Scholar 

  • Kaunitz JD, Sachs G (1986) Identification of a vanadate-sensitive, potassium-dependent proton pump from rabbit colon. J Biol Chem 261:14005–14010

    PubMed  CAS  Google Scholar 

  • Keast JR, Furness JB, Costa M (1985) Different substance P receptors are found on the mucosal epithelial cells and submucous neurons of the guinea pig small intestine. Naunyn Schmiedebergs Arch Pharmacol 329:382–387

    Article  PubMed  CAS  Google Scholar 

  • Kleyman TR, Cragoe EJ (1988) Amiloride and its analogs as tools in the study of ion transport. J Membr Biol 105:1–21

    Article  PubMed  CAS  Google Scholar 

  • Knickelbein RG, Aronson PS, Atherton W, Dobbins JW (1983) Sodium and chloride transport across rabbit ileal brush border. I. Evidence for Na-H exchange. Am J Physiol 245:G504–G510

    PubMed  CAS  Google Scholar 

  • Knickelbein RG, Aronson PS, Dobbins JW (1985) Substrate and inhibitor specificity of anion exchangers on the brush border membrane of rabbit ileum. J Membr Biol 88:199–204

    Article  PubMed  CAS  Google Scholar 

  • Knickelbein RG, Aronson PS, Dobbins JW (1988) Membrane distribution of sodium-hydrogen and chloride-bcarbonate exchangers in crypt and villus cell membranes from rabbit ileum. J Clin Invest 82:2158–2163

    Article  PubMed  CAS  Google Scholar 

  • Knutton S, Limbrick AR, Robertson JD (1978) Structure of occluding junctions in ileal epithelial cells of suckling rats. Cell Tissue Res 191:449–462

    Article  PubMed  CAS  Google Scholar 

  • Levens NR (1984) Modulation of jejunal ion and water absorption by endogenous angiotensin after dehydration. Am J Physiol 246:G700–G709

    PubMed  CAS  Google Scholar 

  • Levens NR, Munday KA, Parsons BJ, Poat JA, Stewart CP (1979) Noradrenaline as a possible mediator of the actions of angiotensin on fluid transport by rat jejunum in vivo. J Physiol (Lond) 286:351–360

    CAS  Google Scholar 

  • Levens NR, Peach MJ, Carey RM, Poat JA, Munday KA (1981a) Response of rat jejunum to angiotensin II: role of norepinephrine and prostaglandins. Am J Physiol 240:G17–G24

    PubMed  CAS  Google Scholar 

  • Levens NR, Peach MJ, Carey RM, Poat JA, Munday KA (1981b) Changes in an electroneutral transport process mediated by angiotensin II in rat distal colon in vivo. Endocrinology 108:1497–1504

    Article  PubMed  CAS  Google Scholar 

  • Liedtke CM (1989) Regulation of Cl transport in epithelia. Annu Rev Physiol 51:143–160

    Article  PubMed  CAS  Google Scholar 

  • Light DB, Corbin JD, Stanton BA (1989) Dual ion channel regulation by cGMP and cGMP-dependent protein kinase. Nature 344:336–339

    Article  Google Scholar 

  • Lopes AG, Siebens AW, Giebisch G, Boron W (1987) Electrogenic Na/HCO3 cotransport across basolateral membrane of isolated perfused Necturus proximal tubule. Am J Physiol 253:F340–F350

    PubMed  CAS  Google Scholar 

  • Madara JL (1991) Functional morphology of epithelium of the small intestine. In: Schultz SG, Field M, Frizzell RA (eds) The gastrointestinal system IV. American Physiological Society, New York, p 83 (Handbook of physiology)

    Google Scholar 

  • Madara JL, Pappenheimer JR (1987) The structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J Membr Biol 100:149–164

    Article  PubMed  CAS  Google Scholar 

  • Madara JL, Trier JS, Neutra MR (1980) Structural changes in the plasma membrane accompanying differentiation of epithelial cells in human and monkey small intestine. Gastroenterology 78:963–975

    PubMed  CAS  Google Scholar 

  • Madara JL, Moore R, Carlton S (1987) Alteration in intestinal tight junction structure and permeability by cytoskeletal contraction. Am J Physiol 253:C854–C861

    PubMed  CAS  Google Scholar 

  • Mailman D (1978) Effects of vasoactive intestinal polypeptide on intestinal absorption and blood flow. J Physiol (Lond) 279:121–132

    CAS  Google Scholar 

  • Mandel KG, Dharmsathaphorn K, McRoberts JA (1986) Characterization of a cAMP-activated Cl transport pathway in the apical membrane of a human colonic epithelial cell line. J Biol Chem 261:704–712

    PubMed  CAS  Google Scholar 

  • Martinez SA, Vidal NA, Carchio SM, Karara AL (1986) Inhibition of water-sodium absorption by an atrial extract. Can J Physiol Pharmacol 64:244–247

    Article  Google Scholar 

  • Maton PN, O’Dorisio TM, Howe BA, McArthur KE, Howard JM, Cherner JA, Malarkey TB, Collen MJ, Gardner JD, Jensen RT (1985) Effect of a long acting somatostatin analog (SMS201,995) in a patient with pancreatic cholera. N Engl J Med 312:17–21

    Article  PubMed  CAS  Google Scholar 

  • McCabe RD, Dharmsathaphorn K (1988) Mechanism of VIP stimulated chloride secretion by intestinal epithelial cells. Ann NY Acad Sci 527:326

    Article  PubMed  CAS  Google Scholar 

  • McCabe RD, Smith PL (1985) Colonic potassium and chloride secretion: role of cAMP and calcium. Am J Physiol 248:G103–109

    PubMed  CAS  Google Scholar 

  • McCabe R, Cooke HJ, Sullivan LP (1982) Potassium transport by rabbit descending colon. Am J Physiol 242:C81–C86

    PubMed  CAS  Google Scholar 

  • McCann JD, Welsh MJ (1990) Regulation of Cl and K channels in airway epithelium. Annu Rev Physiol 52:115–135

    Article  PubMed  CAS  Google Scholar 

  • McCulloch CR, Kuwahara A, Condon CD, Cooke HJ (1987) Neuropeptide modification of Cl secretion in guinea pig distal colon. Regul Pept 19:35–43

    Article  PubMed  CAS  Google Scholar 

  • McFadden D, Zinner MJ, Jaffe BM (1986) Substance P induced intestinal secretion of water and electrolytes. Gut 27:267–272

    Article  PubMed  CAS  Google Scholar 

  • McKay JS, Linaker BD, Turnberg LA (1981) Influence of opiates on ion transport across rabbit ileal mucosa. Gastroenterology 80:279–284

    PubMed  CAS  Google Scholar 

  • McRoberts JA, Beuerlein G, Dharmsathaphorn K (1985) Cyclic AMP and calcium activated K transport in a human colonic epithelial cell line. J Biol Chem 260:14163–14172

    PubMed  CAS  Google Scholar 

  • Miller RJ, Hirning LD (1989) Opioid peptides of the gut. In: Makhlouf GM (ed) Neural and endocrine biology. American Physiological Society, Bethesda, p 631 (Handbook of physiology, sect 6: The gastrointestinal system)

    Google Scholar 

  • Minamino N, Kangawa K, Matsuo H (1984) Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord. Biochem Biophys Res Commun 122:542–549

    Article  PubMed  CAS  Google Scholar 

  • Moghimzadeh E, Ekman R, Hakanson R, Yanaihara N, Sundler F (1983) Neuronal gastrin releasing peptide in the mammalian gut and pancreas. Neuroscience 10:553–563

    Article  PubMed  CAS  Google Scholar 

  • Montrose MH, Kimmich GA (1985) Relative rates of Na/H and Cl/OH exchange reactions in isolated intestinal cells. Ann NY Acad Sci 456:232–234

    Article  PubMed  CAS  Google Scholar 

  • Moriarty KJ, Higgs NB, Lees M, Tonge A, Wardle TD, Warhurst G (1990) Influence of atrial natriuretic peptide on mammalian large intestine. Gastroenterology 98:647–653

    PubMed  CAS  Google Scholar 

  • Morris AP, Kirk KL, Frizzell RA (1990) Simultaneous analysis of cell Ca+2 and Ca+2-stimulated chloride conductance in colonic epithelial cells (HT29). Cell Regul 1:951–963

    PubMed  CAS  Google Scholar 

  • Murer H, Hopfer U, Kinne R (1976) Sodium/proton antiport in brush border membrane vesicles isolated from rat small intestine and kidney. Biochem J 154:597–604

    PubMed  CAS  Google Scholar 

  • O’Grady SM (1989) Cyclic nucleotide-mediated effects of ANF and VIP on flounder intestinal ion transport. Am J Physiol 256:042–046

    Google Scholar 

  • O’Grady SM, Field M, Nash NT, Rao MC (1985) Atrial natriuretic factor inhibits Na-K-Cl cotransport in teleost intestine. Am J Physiol 249:C531–C534

    PubMed  Google Scholar 

  • O’Grady SM, Palfrey HC, Field M (1987) Characteristics and functions of Na-K-Cl cotransport in epithelial tissues. Am J Physiol 253:077–092

    Google Scholar 

  • O’Grady SM, DeJonge HR, Vaandrager AB, Field M (1988) Cyclic nucleotide-dependent protein kinase inhibition by H-8: effects on ion transport. Am J Physiol 254:C115–C121

    PubMed  Google Scholar 

  • Parsons AM, Seybold VS, Chandan R, Vogt J, Larson AA, Murray CR, Soldani G, Brown DR (1992) Neurokinin receptors and mucosal ion transport in porcine jejunum. J Pharmacol Exp Ther 261:1213–1221

    PubMed  CAS  Google Scholar 

  • Patrick MK, Chow O, O’Loughlin EV, Gall DG (1987) The effect of atrial natriuretic factor (ANF) on small intestinal electrolyte transport. Gastroenterology 92:1568

    Google Scholar 

  • Perdue MH, Galbrith R, Davison JS (1987) Evidence for substance P as a functional neurotransmitter in guinea pig small intestinal mucosa. Regul Pept 18:63–74

    Article  PubMed  CAS  Google Scholar 

  • Powell DW (1987) Ion and water transport in the intestine. In: Andreoli TE, Fanestil DD, Hoffman JF, Schultz SG (eds) Membrane transport processes in organized systems. Plenum, New York, p 175

    Google Scholar 

  • Powell DW (1991) Immunophysiology of intestinal electrolyte transport. In: Schultz SG, Field M, Frizzell RA (eds) The gastrointestinal system IV. American Physiological Society, New York, p 591 (Handbook of physiology)

    Google Scholar 

  • Quito FL, Brown DR (1991) Neurohormonal regulation of ion transport in the porcine distal jejunum. Enhancement of sodium and chloride absorption by submucosal opiate receptors. J Pharmacol Exp Ther 256:833–840

    PubMed  CAS  Google Scholar 

  • Racusen LC, Binder HJ (1977) Alteration of large intestinal electrolyte transport by vasoactive intestinal polypeptide in the rat. Gastroenterology 73:790–796

    PubMed  CAS  Google Scholar 

  • Reuss L (1983) Basolateral KCl cotransport in a NaCl absorbing epithelium. Nature 305:723–725

    Article  PubMed  CAS  Google Scholar 

  • Rogers KV, Goldman PS, Frizzell RA, McKnight GS (1990) Regulation of Cl transport in T84 cell clones expressing a mutant regulatory subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci USA 87:8975–8979

    Article  PubMed  CAS  Google Scholar 

  • Schultz SG, Hudson RL (1991) Sodium-coupled transport mechanisms in epithelia. In: Schultz SG, Field M, Frizzell RA (eds) The gastrointestinal system IV. American Physiological Society, New York, p 45 (Handbook of physiology)

    Google Scholar 

  • Schwartz CJ, Kimberg DV, Sheerin HE, Field M, Said SI (1974) Vasoactive intestinal peptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa. J Clin Invest 54:536–544

    Article  PubMed  CAS  Google Scholar 

  • Sellin JH, DeSoignie RC (1984) Rabbit proximal colon: a distinct transport epithelium. Am J Physiol 246:G603–G610

    PubMed  CAS  Google Scholar 

  • Sellin JH, Orayzabal H, Cragoe EJ, Potter GD (1989) Phenamil inhibits electrogenic Na absorption in rabbit ileum. Gastroenterology 96:997–1003

    PubMed  CAS  Google Scholar 

  • Semrad CE, Chang EB (1987) Calcium mediated cyclic AMP inhibition of Na-H exchange in small intestine. Am J Physiol 252:C315–C322.Semrad CE, Cragoe EJ, Chang EB (1991) Inhibition of Na/H exchange in avian intestine by atrial natriuretic factor. J Clin Invest (in press)

    PubMed  CAS  Google Scholar 

  • Sharkey KA, Gall DG, MacNaughton WK (1991) Distribution and function of brain natriuretic peptide in the stomach and small intestine of the rat. Regul Pept 34:61–70

    Article  PubMed  CAS  Google Scholar 

  • Sheldon RJ, Riviere PJM, Malarchik ME, Mosberg HI, Burks TF, Porreca F (1990) Opioid regulation of mucosal ion transport in the mouse isolated jejunum. J Pharmacol Exp Ther 253:144–151

    PubMed  CAS  Google Scholar 

  • Shorofsky SR, Field M, Fozzard HA (1983) Electrophysiology of Cl secretion in canine trachea. J Membr Biol 72:105–115

    Article  PubMed  CAS  Google Scholar 

  • Smith PL, Cascairo MA, Sullivan SK (1985) Sodium dependence of luminal alkalinization by rabbit ileal mucosa. Am J Physiol 249:G358–G368

    PubMed  CAS  Google Scholar 

  • Spring K (1991) Fluid transport across epithelia. In: Schultz SG, Field M, Frizzell RA (eds) The gastrointestinal system IV. American Physiological Society, New York, p 195 (Handbook of physiology)

    Google Scholar 

  • Stewart CP, Turnberg LA (1989) A microelectrode study of responses to secretagogues by epithelial cells on villus and crypt of rat small intestine. Am J Physiol 257:G334–G343

    PubMed  CAS  Google Scholar 

  • Stoll R, Stern H, Ruppin H, Domschke W (1987) Effect of inhibitors on sodium and chloride transport in brush border vesicles from human jejunum and ileum. Digestion 37:228–237

    Article  PubMed  CAS  Google Scholar 

  • Sudoh T, Kangawa K, Minamino N, Matsuo H (1988) A new natriuretic peptide in porcine brain. Nature 332:78–81

    Article  PubMed  CAS  Google Scholar 

  • Sullivan SK, Field M (1991) Ion transport across mammalian small intestine. In: Schultz SG, Field M, Frizzell RA (eds) The gastrointestinal system IV. American Physiological Society, New York, p 287 (Handbook of physiology)

    Google Scholar 

  • Sullivan SK, Smith PL (1986) Active potassium secretion by rabbit proximal colon. Am J Physiol 250:G475–G483

    PubMed  CAS  Google Scholar 

  • Suzuki Y, Kaneko K (1987) Acid secretion in isolated guinea pig colon. Am J Physiol 253:G155–G164

    PubMed  CAS  Google Scholar 

  • Tabcharani JA, Jensen TJ, Riordan JR, Hanrahan JW (1989) Bicarbonate permeability of the outwardly rectifying anion channel. J Membr Biol 112:109–122

    Article  PubMed  CAS  Google Scholar 

  • Tasco M, Orsenigo MN, Eposito G, Faelli A (1988) Na/H exchange mechanism in the basolateral membrane of the rat enterocyte. Biochem Biophys Acta 944:473–476

    Article  Google Scholar 

  • Tatemoto K (1982) Isolation and characterization of peptide YY (PYY): a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc Natl Acad Sci USA 79:2514–2518

    Article  PubMed  CAS  Google Scholar 

  • Tatemoto K, Lundberg JM, Jornvall H, Mutt V (1985) Neurokinin K: isolation, structure and biological activities of a novel brain peptide. Biochem Biophys Res Commun 128:947–953

    Article  PubMed  CAS  Google Scholar 

  • Townsley MC, Machen TE (1989) Na/HCO3 cotransport in rabbit parietal cells. Am J Physiol 257:G350-G356

    PubMed  CAS  Google Scholar 

  • Traynor TR, O’Grady SM (1991) Brain natriuretic peptide stimulates K and Cl secretion across porcine distal colon epithelium. Am J Physiol 260:C750–C755

    PubMed  CAS  Google Scholar 

  • Trimble ER, Burzzone R, Biden TJ, Farese RV (1986) Secretin induces rapid increases in inositol triphosphate, cytosolic Ca+2 and diacylglycerol as well as cAMP in rat pancreatic acini. Biochem J 239:257–261

    PubMed  CAS  Google Scholar 

  • Turnberg LA (1971) Potassium transport in human small bowel. Gut 12:811–818

    Article  PubMed  CAS  Google Scholar 

  • Turnberg LA (1983) Antisecretory activity of opiates in vivo and in vitro. Scand J Gastroenterol 18:79–83

    CAS  Google Scholar 

  • Turnberg LA, Bieberdorf F, Morawski S, Fordtran J (1970a) Interrelationships of chloride, bicarbonate, sodium and hydrogen transport in the human ileum. J Clin Invest 49:557–567

    Article  PubMed  CAS  Google Scholar 

  • Turnberg LA, Fordtran J, Carter N, Rector F (1970b) Mechanism of bicarbonate absorption and its relationship to sodium transport in human jejunum. J Clin Invest 49:548–556

    Article  PubMed  CAS  Google Scholar 

  • Turner JT, Franklin CC, Bollinger DW, Kim HD (1990a) Vasoactive intestinal peptide stimulates active K transport and Na-K-Cl cotransport in HT29 cells. Am J Physiol 258:C266–C273

    PubMed  CAS  Google Scholar 

  • Turner JT, James-Kracke MR, Camden JM (1990b) Regulation of the neurotensin receptor and intracellular calcium mobilization in HT 29 cells. J Pharmacol Exp Ther 253:1049–1056

    PubMed  CAS  Google Scholar 

  • Vaandrager AB, DeJonge HR (1988) A sensitive technique for the determination of anion exchange activities in brush border membrane vesicles; evidence for two exchangers with different sensitivities for HCO3 and SITS in rat intestinal epithelium. Biochem Biophys Acta 939:305–314

    Article  PubMed  CAS  Google Scholar 

  • Vollmar AM, Friedrich A, Sinowatz F, Schultz R (1988) Presence of atrial natriuretic peptide-like material in guinea pig intestine. Peptides 9:965–971

    Article  PubMed  CAS  Google Scholar 

  • Vuolteenaho O, Arjamaa O, Vakkuri T, Maksniemi L, Nikkila K, Kangus J, Puuruuen J, Ruskoaho H, Leppaluoto S (1988) Atrial natriuretic peptide (ANP) in rat gastrointestinal tract. FEBS Lett 233:79–82

    Article  PubMed  CAS  Google Scholar 

  • Wakelam MJO, Murphy GJ, Hruby VJ, Houslay MD (1986) Activation of two signal transduction mechanisms in hepatocytes by glucagon. Nature 323:68–71

    Article  PubMed  CAS  Google Scholar 

  • Waldman DB, Gardner JD, Zfass AM, Makhlouf GM (1977) Effects of vasoactive intestinal polypeptide secretin and related peptides on rat colonic transport and adenylate cyclase activity. Gastroenterology 73:518–523

    PubMed  CAS  Google Scholar 

  • Walling MW, Brasitus TA, Kimberg DV (1977) Effects of calcitonin and substance P on the transport of Ca, Na and Cl across rat ileum in vitro. Gastroenterology 73:89–94

    PubMed  CAS  Google Scholar 

  • Warhurst G, Smith G, Tonge A, Turnberg LA (1983) Effects of morphine on net water absorption, adenylate cyclase activity and PGE2 metabolism in rat intestine. Eur J Pharmacol 86:77–82

    Article  Google Scholar 

  • Welsh MJ (1983) Intracellular chloride activities in canine tracheal epithelium. Direct evidence for Na-coupled intracellular chloride accumulation in a chloride-secreting epithelium. J Clin Invest 74:262–268

    Article  Google Scholar 

  • Welsh MJ, Smith PL, Fromm M, Frizzell RA (1982) Crypts are the site of intestinal fluid and electrolyte secretion. Science 218:1219–1221

    Article  PubMed  CAS  Google Scholar 

  • Wiener H, van Os CH (1989) Rabbit distal colon epithelium. II. Characterization of (Na,K,Cl) cotransport and [3H]bumetanide binding. J Membr Biol 110:163–174

    Article  PubMed  CAS  Google Scholar 

  • Wills NK, Alles WP, Sandle GI, Binder HJ (1984) Apical membrane properties and amiloride binding kinetics of the human descending colon. Am J Physiol 247:G749–G757

    PubMed  CAS  Google Scholar 

  • White JF (1989) Conductive pathways for HCO3 in basolateral membrane of salamander intestinal cells. Am J Physiol 257:C252–C260

    PubMed  CAS  Google Scholar 

  • Woll PJ, Rozengurt E (1989) Neuropeptides as growth regulators. Br Med Bull 45:492–505

    PubMed  CAS  Google Scholar 

  • Wu ZAC, O’Dorisio TM, Cataland C, Mekhijian HS, Gaginella TS (1979) Effects of pancreatic polypeptide and vasoactive intestinal polypeptide on rat ileal and colonic water and electrolyte transport. Dig Dis Sci 24:625–630

    Article  PubMed  CAS  Google Scholar 

  • Yada T, Okada Y (1984) Electrical activity of an intestinal epithelial cell line: hyperpolarizing responses to intestinal secretagogues. J Membr Biol 77:33–44

    Article  PubMed  CAS  Google Scholar 

  • Yada T, Oiki S, Ueda S, Okada Y (1989) Intestinal secretagogues increase cytosolic free Ca2+ concentration and K conductance in a human epithelial cell line. J Membr Biol 112:159–167

    Article  PubMed  CAS  Google Scholar 

  • Zweibaum A, Laburthe M, Grasset E, Louvard D (1991) Use of cultured cell lines in studies of intestinal cell differentiation and function. In: Schultz SG, Field M, Frizzell RA (eds) The gastrointestinal system IV. American Physiological Society, New York, p 223 (Handbook of physiology)

    Google Scholar 

Download references

Authors
  1. S. M. O’Grady
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Veterinary Biology, Pharmacology Section, University of Minnesota, 1988 Fitch Avenue, Saint Paul, MN, 55108, USA

    David R. Brown Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

O’Grady, S.M. (1993). Peptidergic Regulation of Intestinal Electrolyte Transport. In: Brown, D.R. (eds) Gastrointestinal Regulatory Peptides. Handbook of Experimental Pharmacology, vol 106. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77814-8_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77814-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77816-2

  • Online ISBN: 978-3-642-77814-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation