Abstract
Host effector cell populations have received intensive scrutiny in the past decade as investigators have tried new modalities able to destroy tumour cells. A hormone originally called T-cell growth factor and now known as Interleukin-2 (IL-2) was noticed to be capable of inducing in vitro proliferation of these cells. These IL-2 responsive cells and others, such as LAK cells and NK cells, have been used in a multitude of approaches in an attempt to generate antitumour responses in the host [1–4].
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References
Forni G, and Giovarelli M., Strategies for cell- mediated immunotherapy of cancer: Killing or help? Immunology Today 1986 (7) 202–203
Thatcher N, Dazzu H, Johnson RJ, et al: Recombinant lnterleukin-2 given intrasplenically and intravenously for advanced malignant melanoma. A phase I and II study. Br J Cancer 1989 (60):770–774
Hercend T and Schmidt RE: Characteristics and uses of natural killer cells. Immunology Today 1988 (9):291–292
Rosenberg SA: Immunotherapy and gene therapy of cancer. Cancer Res 1991 (51):5074s–5079s
Lotze MT, Line BR, Mathisen DJ, and Rosenberg SA: The in vivo distribuition of autologous human and lymphoid cells grown in T cell growth factor (TCGF): Implications for the adoptive immunotherapyof tumors. J Immunol 1980 (125):1487–1493
Rosenberg SA, Lotze MT, Muul MT et al: Special Report - Observation on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med 1985 (313):1485–1492
Gilboa E: Retrovirus vectors and their use in molecular biology. Bioassay 1986 (5):252
Armentano D, Yu S-F, Kantoff PW, von Ruden T, Anderson WF and Gilboa E: Effect of internal viral sequences on the utility of retroviral vectors. J Virol 1987 (61):1647–1650
Hantzopoulos PA, Sullenger BA, Lingers G, and Gilboa E: Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector. Proc Natl Acad Sci USA 1989 (86) :3519–3523
Oval J, Hershberg R, Gansbacher B, Gilboa E, Schlessinger J, and Taetle R: Expression of functional Epidermal Growth Factor Receptor in a human hematopoetic cell line. Cancer Res 1991 (51):150–156
Gansbacher B, Zier K, Daniels B, Cronin K, Bannerji R, and Gilboa E: IL-2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J Exp Med 1990 (172): 1217
Gansbacher B, Bannerji R, Zier K, Daniels B, Cronin K, and Gilboa E: Retroviral vector mediated IFN- gamma gene transfer into tumor cells generates a potent and long lasting anti-tumor response. Cancer Res 1990
Gansbacher B, Zier K and Golde D: Gene transfer induced constitutive secretion of IL-2 or IFN-gamma by irradiated human melanoma cells. 1991 (submitted)
Greenberg PD, Cheever MS, and Fefer A: Therapy of established tumors by adoptive transfer of T lymphocytes. In: Herberman RB (ed) Basic and Clinical Tumor Immunology. Martinus Nijhoff Publishers 1983 p 301
Matis LA, Shu ES, Groves S: Adoptive immunotherapy of a syngeneic murine leukemia with a tumor-specific cytotoxic T cell clone and recombinant human interleukin2: correlation with clonal IL-2 receptor expression. J Immunol 1986 (136):3490
North RJ: Models of adoptive T-cell mediated regression of established tumors. Contemp Top Immunobiol 1984 (13):243
Rosenberg SA, Spiess P and Lafreniere R: A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes. Science 1986 (233): 1318
Rosenberg SA, Packard BS, Aebersold PM et al: Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. New Engl J Med 1988 (319): 1676
Alosco TR, Croy BA, Gansbacher B, Wang HQ, Rao U and Bankaert R: Tumor cells secreting IL2 stimulate a local anti-tumor response independent of functional B or T lymphocytes. J Exp Med 1992 (in press)
Miller RG: An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it. Nature 1980 (287):544
Rammensee JG, Bevan JJ and Fink PJ: Antigen specific suppression of T-cell responses: the veto concept. Immunol Today 1985 (6):41
North RJ: Radiation-induced, immunologically mediated regression of an established tumor as an example of successful therapeutic immunomanipulation. J Exp Med 1986 (164): 1652
Joly P, Guillon J-M, Mayaud et al: Cell-mediated suppression of HIV-specific cytotoxic T lymphocytes. J Immunol 1989 (143): 2193
Keshem B and Kedar E: Cytotoxic T lymphocytes reactive against a syngeneic murine tumor and their specific suppressor T cells are both elicited by in vitro allosensitization. J Exp Med 1990 (171): 1057
Eura MT, Maehara T, Ikawa T and Iskikawa T: Suppressor cells in the effector phase of autologous cytotoxic reactions in cancer patients. Cancer Immunol Immunother 1988 (27):147
Podack ER: The molecular mechanism of lymphocyte-mediated tumor cell lysis. Immunol Today 1985 (6):21
Smyth MJ, Ortaldo JR, Shinkai YL: Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8 T cells. J Exp Med 1990 (171 ): 1269
Liu C-C, Joag SV, Kwon BS and Young JD-E: Induction of perforin and serine esterases in a murine cytotoxic T lymphocyte clone. J Immunol 1990 (144): 1196
Smyth, MJ, Ortaldo JR and Bere W: IL-2 and IL-6 synergize to augment the pore-forming protein gene expression and cytotoxic potential of human peripheral blood T cells. J Immunol 1990 (145): 1159
Barth RJ, Mule JJ, Spiess PJ, Rosenberg SA: Interferon gamma and tumor necrosis factor alpha have a role in tumor regression mediated by murine CD8 tumor infiltrating lymphocytes. J Exp Med 1991 (173):647–658
Schwartzentruber DJ, Topolian SN, Mancini M and Rosenberg SA: Specific release of granulocyte- macrophage colony stimulating factor, tumor necrosis factor-alpha, and interferon-gamma by human tumor infiltrating lymphocytes after autologous tumor stimulation. J Immunol 1991 (146):3674–3681
Nishihara K, Miyatake S, Sakata T, Yamashita J, Kikuchi H, Kawade Y, Zu Y, Namba Y, Hanaoka M, Watanabe Y: Augmentation of tumor targeting in a line of glioma-specific mouse cytotoxic T- lymphocytes by retroviral expression of mouse gamma-interferon complementary DNA. Cancer Res 1988 (48/17):4730–4735
Rosenberg SA, Aebersold P, Cornetta K, Kasid A, Morgan RA, Moen R, Karson EM, Lotze MT, Yang JC, Topalian SL: Gene transfer into humans - immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. New Engl J Med 1990 (323):570–578
Kasid A, Morecki S, Aebersold P, Cornetta K, Culver K, Freeman S, Director E, Lotze MT, Blaese RM, Anderson WF: Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man. Proc Natl Acad Sci USA 1990(87) :473–477
Morecki S, Karson E, Cornetta K, Kasid A, Aebersold P, Blaese RM, Anderson WF, Rosenberg SA: Retrovirus-mediated gene transfer into CD4+ and CD8+ human T cell subsets derived from tumor- infiltrating lymphocytes and peripheral blood mononuclear cells. Cancer Immunol Immunother 1991 (32/6):342–352
Tepper RI, Pattengale PK and Leder P: Murine interleukin-4 displays potent anti-tumor activity in vivo. Cell 1989 (57):503
Colombo MP, Ferrari G, Stoppacciaro A et al: Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo. J Exp Med 1991 (173):889
Wantanabe Y, Kuribayashi K, Miyatake S: Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity. Proc Natl Acad Sci USA 1989 (86):9456
Fearon ER, Pardoll DM, Itaya T, et al: lnterleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell 1990 (60):397
Russell SJ: Lymphokine gene therapy for cancer. Immunol Today 1990 (11):196
Russell SJ, Eccles SA, Flemming CL, Johnson CA, Collins MK: Decreased tumorigenicity of a transplantable rat sarcoma following transfer and expression of an IL-2 cDNA. Int J Cancer 1991 (47):244–251
Blankenstein T, Li WQ, Muller W, Diamantstein T: Retroviral interleukin 4 gene transfer into an interleukin 4-dependent cell line results in autocrine growth but not in tumorigenicity. Eur J Immunol 1990 (20/4):935–938
Golumbek PT, Lazenby AT, Levitzky HI, Jaffee LM, Karasuyama H, Baker M, Pardoll DM: Treatment of established renal cancer engineered to secrete lnterleukin-4. Science 1991 (254):713–716
Watanabe Y, Kuribayashi K, Miyatake S, Nishihara K, Nakayama E, Taniyama T, Sakata T: Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented tumor immunity. Proc Natl Acad Sci USA 1989 (86/23):9456–9460
Watanabe Y, Sakata T: Highly efficient action of autocrine mouse interferon-gamma expressed via a retroviral vector. Eur J Immunol 1988 (18):1627–1630
Blankenstein T, Qin ZH, Uberla K, Müller W, Roser H, Volk HD, Diamantstein T: Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer. J Exp Med. 1991(173):1047–1052
Asher AL, Mule JJ, Kasid A, Restifo NP, Salo JC, Reichert CM, Jaffe G, Fendly B, Kriegler M, and Rosenberg SA: Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. J Immunol 1991 (146): 3227–3234
Blankenstein T, Li WQ, Uberla K, Qin ZH, Tominaga A, Takatsu K, Yamaguchi N, Diamantstein T: Retroviral interleukin 5 gene transfer into interleukin 5-dependent growing cell lines results in autocrine 51 growth and tumorigenicity. Eur J Immunol 1990 (20):2699–2705
Scala G, Quinto I, Ruocco MR, Arcucci A, Maliardo M, Carette P, Forni G and Venuta S: Expression of 52 an exogenous Interleukin 6 gene in human Epstein Barr virus B cells confers growth advantage and in vivo tumorigenicity. J Exp Med 1990 (172):61–68
Suematsu S, Matsuda T, Aozasa K, Akira N, Nakano N, Ohno S, Miyazaki J, Yamamura K, Hirano T, Kishimoto T: lgG1 plasmacytosis in Interleukin 6 transgenic mice. Proc Natl Acad Sci USA 1989 (86):7547
Crowley NJ, Slinghuff CL, Darrow TL, Siegler HF: Generation of human autologous tumor specific cytotoxic T cells using HLA-A2 mathced allogenic melanoma. Cancer Res 1990 (50):492
Crowley NJ, Darrow TL, Quinn-Allen MA et al: MHC- restricted recognition of autologous melanoma by tumor-specific cytotoxic T cells. Evidence for restriction by a dominant HLA-A allele. J Immunol 1991 (146):1692–1699
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© 1992 Springer-Verlag Berlin Heidelberg
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Gansbacher, B. (1992). Cytokine Gene Therapy of Cancer. In: Mertelsmann, R. (eds) Lymphohaematopoietic Growth Factors in Cancer Therapy II. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77801-8_5
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DOI: https://doi.org/10.1007/978-3-642-77801-8_5
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