The Metabolic Protection of Hypoxia by Etomidate Evaluated by Magnetic Resonance Spectroscopy

  • K. Yoshida
  • A. Marmarou
  • M. Furuse
Conference paper

Abstract

Prolonged hypoxia leads to increase of the rate of anaerobic glycolysis and hence the accumulation of lactate. There is a progressive fall in intracellular pH of brain and energy disturbances. The objective of this study was, using magnetic resonance spectroscopy, to determine if Etomidate could ameliorate brain metabolic derangements resulting from the hypoxic energy crisis.

Keywords

Catheter Ischemia Lactate Platinum Bromide 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Dearden NM, Mcdowell DG (1985) Comparison of etomidate and althesin in the reduction of increased intracranial pressure after head injury. Br J Anaesth 57:361–368PubMedCrossRefGoogle Scholar
  2. 2.
    Giese JL, Stanley TH (1983) Etomidate: A new intravenous anesthetic induction agent. Pharmacotherapy 3:251–258PubMedGoogle Scholar
  3. 3.
    Gilsanz FJ, Sola G, Mateos LT, Hernandez C (1986) Effects of etomidate, sodium pentothal and lidocaine on cerebral elastance. ICP 6:736–739Google Scholar
  4. 4.
    Moss E, Powell D, Gibson RM, Mcdowall DG (1979) Effect of etomidate on intracranial pressure and cerebral perfusion pressure. Br J Anaesth 51:347–352PubMedCrossRefGoogle Scholar
  5. 5.
    Norberg K, Siesjo BK (1975) Cerebral metabolism in hypoxic hypoxia 1. Pattern of activation of glycolysis: A re-evaluation. Brain Res 86:31–44PubMedCrossRefGoogle Scholar
  6. 6.
    Siesjo BK, Nilsson L (1971) The influence of arterial hypoxemia upon labile phosphates and upon extracellular and intracellular lactate and pyruvate concentration in the rat brain. Scand J Clin Lab Invest 27:83–96PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • K. Yoshida
    • 1
  • A. Marmarou
    • 1
  • M. Furuse
    • 2
  1. 1.Division of NeurosurgeryMedical College of VirginiaUSA
  2. 2.Nakatsugawa Municipal General HospitalJapan

Personalised recommendations