The Metabolic Protection of Hypoxia by Etomidate Evaluated by Magnetic Resonance Spectroscopy

  • K. Yoshida
  • A. Marmarou
  • M. Furuse
Conference paper


Prolonged hypoxia leads to increase of the rate of anaerobic glycolysis and hence the accumulation of lactate. There is a progressive fall in intracellular pH of brain and energy disturbances. The objective of this study was, using magnetic resonance spectroscopy, to determine if Etomidate could ameliorate brain metabolic derangements resulting from the hypoxic energy crisis.


Intracranial Pressure Cerebral Perfusion Pressure Anaerobic Glycolysis Cerebral Metabolism Normal Ventilation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • K. Yoshida
    • 1
  • A. Marmarou
    • 1
  • M. Furuse
    • 2
  1. 1.Division of NeurosurgeryMedical College of VirginiaUSA
  2. 2.Nakatsugawa Municipal General HospitalJapan

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