Microautoradiographic Examination of Edema Fluid Distribution in the Cat Brain After Cryogenic Injury
We recently reported that maximal accumulation of edema fluid after cold-lesioning was not observed in the white matter of the injured gyrus but in the deeper white matter under the gyrus . However, this result was equivocal, since the observed accumulation of the tracer for edema fluid, 125I-labeled albumin, may have merely reflected the change in the vascular space due to the cold injury. The purpose of the present study was (i) to examine micro-autoradiographically the distribution of 125I-labeled albumin in the edematous area to clarify whether the increase was, in fact, due to increased extravascular accumulation, and (ii) to elucidate histologically the structural characteristics of the deep white matter showing maximal accumulation of edema fluid in cold-lesion edema.
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