Effect of Propofol on Cerebro-Spinal Fluid Pressure in Patients with and without Intracranial Hypertension

  • P. Ravussin
  • R. Tempelhoff
  • P. A. Modica
  • J. P. Guinard
  • D. Thorin
  • J. Freeman
Conference paper

Abstract

Propofol has been shown to be a suitable agent for neuroanesthesia [2]. It decreases cerebral oxygen consumption (CMRO2) and cerebral blood flow (CBF), and increases cerebral vascular resistance [4]. Intracranial pressure (ICP) decreases as a result of the effects of propofol on cerebral hemodynamics [2]. In this study [2], baseline ICP of the 23 patients before propofol ranged from 6 to 32 mmHg. Accordingly, the present study was designed to evaluate and to quantify prospectively the cerebrospinal fluid pressure (CSFP) decreasing effect of propofol in patients with and without intracranial hypertension (ICH) to determine whether their ICP reacts in the same way to propofol and to the same degree in both groups.

Keywords

Quartz Fentanyl Lidocaine Barbiturate Thiopentone 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • P. Ravussin
    • 1
  • R. Tempelhoff
    • 2
  • P. A. Modica
    • 2
  • J. P. Guinard
    • 1
  • D. Thorin
    • 1
  • J. Freeman
    • 1
  1. 1.Department of AnesthesiologyCentre Hospitalier Universitaire VaudoisLausanneSwitzerland
  2. 2.Department of Anesthesiology, Division of NeuroanesthesiaWashington School of MedicineSt. LouisUSA

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