Pharmacokinetic Analysis of Mannitol in Relation to the Decrease of ICP
Mannitol has been used for the reduction of raised intracranial pressure (ICP) for years, however, the most effective dose and the method of administration have remained controversial [2, 3]. One of the reasons is that the pharmacokinetics of mannitol has not been clearly understood in relation to the changes of mannitol concentration and serum osmolality and the decrease of ICP after the mannitol administration .
KeywordsPeripheral Compartment Serum Osmolality Mannitol Concentration Epidural Pressure Mannitol Group
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