Pharmacokinetic Analysis of Mannitol in Relation to the Decrease of ICP

  • H. Takagi
  • M. Tanaka
  • T. Ohwada
  • F. Tomonaga

Abstract

Mannitol has been used for the reduction of raised intracranial pressure (ICP) for years, however, the most effective dose and the method of administration have remained controversial [2, 3]. One of the reasons is that the pharmacokinetics of mannitol has not been clearly understood in relation to the changes of mannitol concentration and serum osmolality and the decrease of ICP after the mannitol administration [1].

Keywords

Creatinine Rubber Mannitol Furosemide Pentobarbital 

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References

  1. 1.
    Cloyd JC, Synder BD, Cleeremans B, Bundie SR (1986) Mannitol pharmacokinetics and serum osmolality in dogs and humans. J Pharmacol Exp Ther 23:301–306Google Scholar
  2. 2.
    Marshall LF, Smith RW, Rausher LA, Shapiro HM (1978) Mannitol dose requirements in brain injured patients. J Neurosurg 48:169–172PubMedCrossRefGoogle Scholar
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    Roberts PA, Pollay M, Engles C, Pendleton B, Reynolds E, Stevens FL (1987) Effect on intercranial pressure of furosemide combined with various dose and administration rates of mannitol. J Neurosurg 66:440–446PubMedCrossRefGoogle Scholar
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    Yamaoka K (1984) Method of pharmacokinetic analysis by personal computer. Nanzando, TokyoGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • H. Takagi
    • 1
    • 2
  • M. Tanaka
    • 1
    • 2
  • T. Ohwada
    • 1
    • 2
  • F. Tomonaga
    • 1
    • 2
  1. 1.Department of NeurosurgeryYamato City HospitalYamato, KanagawaJapan
  2. 2.School of Pharmaceutical ScienceKitasato UniversitySagamihara, KanagawaJapan

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