Cerebral Perfusion Pressure Management of Head Injury
Previous work has demonstrated a causal relationship between unstable cerebral perfusion pressure (CPP) and the development of intracranial pressure (ICP) waves . The genesis of this CPP instability has usually (though not exclusively) been decrements in systemic arterial blood pressure (SABP). A simple model termed the “Vasodilatory Cascade” has been developed which demonstrates the interrelationships which lead to the complex interaction of SABP, ICP, and CPP . More importantly, the “Cascade” model in a more complex form leads directly to a model which helps interrelate both positive and negative aspects of many therapeutic modalities and their effect upon the whole system. From this understanding, a model upon which therapy  can be based has been developed and serves as the basis for the current report.
KeywordsHydration Albumin Dopamine Lactate Mannitol
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