Intracranial Distension in Neurosurgical Pathology
Since the classical studies on ICP by Cushing, the main methodological principle for most investigators is based on the a priori postulate that the pressure in the cranial cavity is evenly distributed. This starting point made it possible to characterize the overall ICP by the pressure in one compartment only: the epidural, subdural or the, most widely used, ventricular fluid pressure (VFP). During recent decades, two important facts have emerged. 1. The mechanical pressures of the intracranial constituents [brain tissue, cerebrospinal fluid (CSF), interstitial fluid (ISF)] are different in their absolute values [3, 4, 5, 6, 8]. 2. An uneven distribution of pressures between the various intracranial compartments has been demonstrated in neurosurgical pathology [2, 6, 7].
KeywordsBrain Edema Intact Tissue Oxybate Sodium Infratentorial Tumour Intracerebral Pressure
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