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Nebenwirkungen und Risiken der Benzodiazepinantagonisierung

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Part of the book series: Klinische Anästhesiologie und Intensivtherapie ((KAI,volume 42))

Zusammenfassung

Seit der Einführung von Flumazenil, einem kompetitiven Antagonisten, bietet sich die Möglichkeit, das Prinzip von Actio und Reactio, das für natürliche Steuerungsprozesse evolutionär ausgebildet und für die Feinsteuerung von Lebensvorgängen nahezu unerläßlich ist, nicht nur für den Bereich der nichtdepolarisierenden Muskelrelaxanzien und Opiate anzuwenden, sondern auch den Benzodiazepineinsatz in Anästhesie und Intensivmedizin nach diesem Prinzip zu erleichtern.

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Literatur

  1. Artru A (1989) Flumazenil reversal of midazolam in dogs: Dose related changes in cerebral blood flow, metabolism, EEG, and CSF pressure. J Neurosurg Anesth 1: 46–55

    Article  CAS  Google Scholar 

  2. Artru A (1990) The rate of CSF formation, resistance to reabsorption of CSF, and aperiodic analysis of the EEG following administration of flumazenil to dogs. Anesthesiology 72: 111–117

    Article  CAS  PubMed  Google Scholar 

  3. Ashton HC (1989) Benzodiazepine overdose: are specific antagonists useful? Br Med J 290: 805–806

    Article  Google Scholar 

  4. Bodenham AR (1989) Death after flumazenil. Br Med J 299: 457

    Article  CAS  Google Scholar 

  5. Bradley M, Wray R, Leach A, Nama M (1989) Flumazenil causing convulsions and ventricular tachycardia. Br Med J 299: 860

    Google Scholar 

  6. Burr W, Sandham P, Judd A (1989) Death after flumazenil. Br Med J 298: 1713

    Article  CAS  Google Scholar 

  7. Chiolero RL, Ravussin P, Anderes JP,Tribolet N de, Freeman J (1986) Midazolam reversal with Ro 15–1788 in patients with sever head injury. Anesthesiology 65: A 358

    Article  Google Scholar 

  8. Darragh A, Lambe R, Kenny M, Brick I (1983) Tolerance of healthy volunteers to intravenous administration of the benzodiazepine antagonist Ro 15–1788. Eur J Clin Pharmacol 24: 569–570

    Article  CAS  PubMed  Google Scholar 

  9. Duka T, Ackenheil M, Noderer J, Doenicke A, Dorow R (1986) Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15–1788. Psychopharmacology 90: 531–537

    Article  Google Scholar 

  10. Fleischer JE, Milde JH, Moyer TP, Michenfelder JD (1988) Cerebral effects of high dose midazolam and subsequent reversal with Ro 15-1788 in dogs. Anesthesiology 68: 234–242

    Article  CAS  PubMed  Google Scholar 

  11. Forster A, Juge O, Louis M, Nahory A (1987) Effect of a specific benzodiazepine antagonist (Ro 15-1788) on cerebral blood flow. Anesth Analg 66: 309–313

    CAS  PubMed  Google Scholar 

  12. Hruby K, Prischl F, Smetana R, Pernecker M, Donner A, Scholtz I, Grimm G (1987) Spezifische Therapie der akuten Benzodiazepinintoxikation mittels Flumazenil. MMW 137/9: 179–183

    Google Scholar 

  13. Klausen NO, Sorensen J, Ferguson AH, Neumann PB, Larsen C, Juhl O (1986) Stress response during recovery after total intravenous anaesthesia with midazolam and fentanyl reversed by Ro 15–1788. In: Beiträge zur Anaesthesiologie und Intensivmedizin 16: VII. European Congress of Anaesthesiology (abstr 133)

    Google Scholar 

  14. Kulka P, Lauven PM (1990) Comparison of two total intravenous anaesthesia techniques for laryngoscopic laser surgery under jet-ventilation: Midazolam/flumazenil vs. methohe-xital. Acta Anaesth Scand. 34 (Suppl 92): 90–96

    Article  Google Scholar 

  15. Lauven PM, Kulka P (1988) Antagonisierung der Benzodiazepinwirkung mit Flumazenil (Ro 15-1788). Anästh Intensivther Notfallmed 23: 153–158

    Article  CAS  PubMed  Google Scholar 

  16. Lauven PM, Ebeling BJ, Stoeckel H, Dierke-Dzierzon C (1986) Wirksamkeit des Benzodiazepin-Antagonisten Ro 15-1788 nach einer Anästhesie mit Flunitrazepam-Einleitung. Anästh Intensivther Notfallmed 21: 311–314

    Article  CAS  PubMed  Google Scholar 

  17. Lim AG (1989) Death after flumazenil. Br Med J 299: 1531

    Google Scholar 

  18. Little HJ, Bichard R (1984) Differential effect of the benzodiazepam antagonist Ro 15-1788 after “general anaesthetic” doses of benzodiazepines in mice. Br J Anaesth 56: 1153–1159

    Article  CAS  PubMed  Google Scholar 

  19. Lukas SE, Griffiths R (1984) Precipitated diazepam withdrawel in baboons: Effects of dose and duration of diazepam exposure. Eur J Pharmacol 100: 163–171

    Article  CAS  PubMed  Google Scholar 

  20. Marty J, Nitenber A, Blanchet F, Zouioueche S, Desmonts JM (1986) Effects of midazolam on the coronary circulation in patients with coronary artery desease. Anaesthesiology 64: 206–210

    Article  CAS  Google Scholar 

  21. Mora CT,Torjman M,White PF (1989) Effects of diazepam and flumazenil on sedation and hypoxic ventilatory response. Anesth Analg 68: 473–478

    CAS  PubMed  Google Scholar 

  22. Polc P, Bonetti E, Cumin R, Laurent JP, Pieri L, Schaffner R, Scherschlicht R (1982) Neuropharmacology of the selective benzodiazepine antagonist Ro 15-1788. In: Usdin et al. (eds) Pharmacology of benzodiazepines. Macmillan, London, p 405

    Google Scholar 

  23. Raeder JC, Hole A, Arnulf V, Hougens Grynne B (1987) Total intravenous anaesthesia with midazolam and flumazenil. Acta Anaesth Scand 31: 634–641

    Article  CAS  PubMed  Google Scholar 

  24. Ritter JW, Hacke WE, Norel E, Gion H, Chen R, Hoskizaki G (1988) Adrenergic and hemodynamic response to flumazenil (Ro 15-1788) reversal of midazolam sedation. Anesthesiology 69: A 109

    Article  Google Scholar 

  25. Schulte am Esch J, Kochs E (1990) Midazolam and flumazenil in neuroanaesthesia. Acta Anaesthesiol Scand 34/92: 96–102

    Article  Google Scholar 

  26. Scollo-Lavizarri G (1983) First clinical investigation of the benzodiazepine antagonist Ro 15-1788 in comatose patients. Eur Neurol 22: 7–11

    Article  Google Scholar 

  27. Smith DE (1979) Importance of gradual dosage reduction following low dose benzodiazepine therapy. Newslett Calif Soc Treat Alcohol Drug Depend 6: 1–3

    Google Scholar 

  28. Tolksdorf W, Pirwitz A, Bentzinger C, Pfeiffer J (1987) Ro 15-1788 antagonisiert zuverlässig die Benzodiazepin Wirkung nach Flunitrazepam-Kombinationsnarkosen. Anästhesist 36: 203–209

    CAS  Google Scholar 

  29. White PF, Shafer A, Boyle WA, Doze A van, Duncan S (1989) Benzodiazepine antagonism does not provoke a stress response. Anesthesiology 70: 636–639

    Article  CAS  PubMed  Google Scholar 

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© 1993 Springer-Verlag Berlin Heidelberg

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Lauven, P.M., Kulka, P. (1993). Nebenwirkungen und Risiken der Benzodiazepinantagonisierung. In: Rügheimer, E. (eds) Konzepte zur Sicherheit in der Anästhesie. Klinische Anästhesiologie und Intensivtherapie, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77781-3_9

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  • DOI: https://doi.org/10.1007/978-3-642-77781-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55931-3

  • Online ISBN: 978-3-642-77781-3

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