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Zwischenfälle bei der Anwendung von Lokalanästhetika

  • Conference paper
Konzepte zur Sicherheit in der Anästhesie

Part of the book series: Klinische Anästhesiologie und Intensivtherapie ((KAI,volume 42))

Zusammenfassung

Lokalanästhetika sind Medikamente, deren Wirkungsmechanismus auf einer reversiblen Blockade elektrisch erregbarer Gewebe beruht. In der klinischen Anwendung zählen hierzu vornehmlich freie Nervenendigungen und Nervenfasern in der Körperperipherie bzw. im Rückenmark. Andere exzitable Strukturen im Herzen sowie im Gehirn werden natürlich ebenfalls beeinflußt; Lokalanästhetika werden deshalb auch als Antiarrhythmika bzw. Antikonvulsiva eingesetzt. Für die therapeutische Lokalanästhesie ist damit das Spektrum der wichtigsten Nebenwirkungen vorgezeichnet.

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Literatur

  1. Abraham RA, Harris AS, Maxwell LG, Kaplow S (1986) The efficacy of 1,5 % lidocaine with 7,5 % dextrose and epinephrine as an epidural test dose for obstetrics. Anesthesiology 64:116–119

    CAS  PubMed  Google Scholar 

  2. Ackermann WE, Juneja MM, Knapp RK (1990) Maternal paraparesis after epidural anesthesia and cesarean section. South Med J 83:695–697

    Google Scholar 

  3. Adriani J, Campbell D (1956) Fatalities following topical administration of local anesthetics to mucous membranes. JAMA 162:1527–1530

    CAS  Google Scholar 

  4. Ahn JC, Stanley JA (1987) Subarachnoid injection as a complication of retrobulbar anesthesia. Am J Ophthalmol 103:225–230

    CAS  PubMed  Google Scholar 

  5. Albright GA (1979) Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology 51:285–287

    CAS  PubMed  Google Scholar 

  6. Albright GA (1983) Clinical aspects of bupivacaine toxicity. Presentation to the Food and Drug Administration, Anesthetic and Life Support Drugs Advisory Committee, October 4

    Google Scholar 

  7. Aldrete JA, Romo-Salas F, Arora S,Wilson R, Rutherford R (1978) Reverse arterial blood flow as a pathway for central nervous toxic responses following injection of local anesthetics. Anesth Analg 57:428–433

    CAS  PubMed  Google Scholar 

  8. Ameer B, Bulingame MB, Harman EM (1989) Systemic absorption of topical lidocaine in elderly and young adults undergoing bronchoscopy. Pharmacotherapy 9:74–81

    CAS  PubMed  Google Scholar 

  9. Anderson ST, Hajduczek J, Barker SJ (1988) Benzocaine-induced methemoglobinemia in an adult: accuracy of pulse oximetry with methemoglobinemia. Anesth Analg 67:1099–1101

    CAS  PubMed  Google Scholar 

  10. Antonelli D, Bloch L (1982) Sinus standstill following lidocaine administration. JAMA 248:827–828

    CAS  PubMed  Google Scholar 

  11. Assem ESK, Punnia-Moorthy A (1988) Allergy to local anesthetics: an approach to definitive diagnosis. A review with an illustrative study. Br Dent J 164:44–47

    CAS  PubMed  Google Scholar 

  12. Avery P, Redon D, Schaenzer G, Rusy B (1984) The influence of serum potassium on the cerebral and cardiac toxicity of bupivacaine and lidocaine. Anesthesiology 61:134–138

    CAS  PubMed  Google Scholar 

  13. Babjews AV, Ivanyi L (1982) The relationship between in vivo and in vitro reactivity of patients with a history of allergy to local anesthetics. Br Dent J 152:385–387

    Google Scholar 

  14. Bader AM, Concepcion M, Hurley RJ, Arthur GR (1988) Comparison of lidocaine and prilocaine for intravenous regional anesthesia. Anesthesiology 69:409–412

    CAS  PubMed  Google Scholar 

  15. Bardoczky GI,Wathieu W, D’Hollander A (1990) Prilocaine-induced methemoglobinemia evidenced by pulse oximetry. Acta Anaesthesiol Scand 34:162–164

    CAS  PubMed  Google Scholar 

  16. Beeby DG, Jenkins JG (1984) The bupivacaine controversy. Anasthesia 39:841

    CAS  Google Scholar 

  17. Bigler D, Lund C, Mogensen T, Hjortso NC, Kehlet H (1987) Tachyphylaxis during postoperative epidural analgesia — new insights. Acta Anaesthesiol Scand 31:664–665

    CAS  PubMed  Google Scholar 

  18. Bokesch PM, Raymond SA, Strichartz GR (1987) Dependence of lidocaine potency on pH and pC02. Anesth Analg 66:9–17

    CAS  PubMed  Google Scholar 

  19. Bowdle TA, Freund PR, Slattery JT (1987) Propranolol reduces bupivacaine clearance. Anesthesiology 66:36–38

    CAS  PubMed  Google Scholar 

  20. Brown DT, Beamish D, Wildsmith JAW (1981) Allergic reaction to an amide local anaesthetic. Br J Anesth 53:435–437

    CAS  Google Scholar 

  21. Buckman K, Claiborne K, de Guzman M, Walberg CB, Haywood LJ (1980) Lidocaine efficacy and toxicity assessed by a new rapid method. Clin Pharmacol Ther 28:177–181

    CAS  PubMed  Google Scholar 

  22. Burket MW, Fraker TD,Temesy-Armos PN (1985) Polymorphous ventricular tachycardia provoked by lidocaine. Am J Cardiol 55:592–593

    CAS  PubMed  Google Scholar 

  23. Burne D, Doughty A (1964) Methaemoglobinaemia following lignocaine. Lancet II:971

    Google Scholar 

  24. Cartwright PD, McCarroll SM, Antzaka C (1986) Maternal heart rate changes with a plain epidural test dose. Anesthesiology 65:226–228

    CAS  PubMed  Google Scholar 

  25. Chandler MJ, Grammer LC, Patterson R (1987) Provocative challenge with local anesthetics in patients with a prior history of reaction. J Allergy Clin Immunol 79:883–886

    CAS  PubMed  Google Scholar 

  26. Chase D, Bray JP (1977) Ventricular tachycardia in a neonate with mepivacaine toxicity. J Pediatr 90:127–129

    CAS  PubMed  Google Scholar 

  27. Chestnut DH (1989) What is new in obstetric anesthesia? Anesth Analg Rev Course Lectures, p. 1–6

    Google Scholar 

  28. Clarkson CW, Hondeghem LM (1985) Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole. Anesthesiology 62:396–405

    CAS  PubMed  Google Scholar 

  29. Collins JF (1990) Methemoglobinemia as a complication of 20 % benzocaine spray for endoscopy. Gastroenterology 98:211–213

    CAS  PubMed  Google Scholar 

  30. Conklin KA, Ziadlou-Rad R (1983) Bupivacaine cardiotoxicity in a pregnant patient with mitral valve prolapse. Anesthesiology 58:596

    CAS  PubMed  Google Scholar 

  31. Covino BG, Vassallo HG (eds) (1976) Local Anesthetics: Mechanisms of Action and Clinical Use. The Scientific Basis of Clinical Anesthesia. Grune & Stratton, New York

    Google Scholar 

  32. Covino BG, Marx GF, Finster M, Zsigmond EK (1980) Prolonged sensory/motor deficits following inadvertent spinal anesthesia. Anesth Analg 59:399–400

    CAS  PubMed  Google Scholar 

  33. Covino BG (1988) Toxicity of local anesthetic agents. Acta Anaesthesiol Belg 39 (Suppl 2):159–164

    CAS  PubMed  Google Scholar 

  34. Dalens B (1989) Regional anesthesia in children. Anesth Analg 68:654–672

    CAS  PubMed  Google Scholar 

  35. Davis NL, de Jong RH (1982) Successful resuscitation following bupivacaine overdose. Anesth Analg 61:62

    CAS  PubMed  Google Scholar 

  36. Deacock AR, Simpson WT (1964) Fatal reactions to lignocaine. Anasthesia 19:217–221

    CAS  Google Scholar 

  37. Deas TC (1956) Severe methemoglobinemia following dental extractions under lidocaine anesthesia. Anesthesiology 17:204

    CAS  PubMed  Google Scholar 

  38. Demczuk RJ (1984) Significant sinus bradycardia following intravenous lidocaine injection. Anesthesiology 60:69–70

    CAS  PubMed  Google Scholar 

  39. van Dorsten JP, Miller FC (1981) Fetal heart rate changes after accidental intrauterine lidocaine. Obstet Gynecol 57:257–260

    PubMed  Google Scholar 

  40. de Jong RH, Heavner JE (1973) Diazepam and lidocaine-induced cardiovascular changes. Anesthesiology 39:633–638

    PubMed  Google Scholar 

  41. de Jong RH, Davis NL (1981) Treating bupivacaine arrhythmias. Reg Anesth 6:51–54

    Google Scholar 

  42. Dhuner K, Lewis D (1966) Effect of local anaesthetics and vasoconstrictors upon regional blood flow. Acta Physiol Scand 23 (Suppl): 347–352

    CAS  Google Scholar 

  43. Duncan PG, Kobrinsky N (10983) Prilocaine-induced methemoglobinemia in a newborn infant. Anesthesiology 59:75–76

    Google Scholar 

  44. Eledjam JJ, de la Coussaye JE, Colson P, Viel E, Bassoul B, Bertinchant JP, d’Athis F (1989) Is epidural anaesthesia using bupivacaine safe in patients with atrio-ventricular conduction defects? Acta Anaesthesiol Scand 33:402–404

    CAS  PubMed  Google Scholar 

  45. Engberg G, Danielson K, Henneberg S, Nilsson A (1987) Plasma concentrations of prilocaine and lidocaine and methaemoglobin formation in infants after epicutaneous application of a 5% lidocaine-prilocaine cream (EMLA). Acta Anaesthesiol Scand 31:624–628

    CAS  PubMed  Google Scholar 

  46. Englesson S (1974) The influence of acid-base changes on central nervous system toxicity of local anaesthetic agents I. Acta Anaesthesiol Scand 18:79–87

    CAS  PubMed  Google Scholar 

  47. Fibuch EE, Opper SE (1989) Back pain following epidurally administered Nesacaine-MPF. Anesth Analg 69:113–115

    CAS  PubMed  Google Scholar 

  48. Fisher MM, Pennington JC (1982) Allergy to local anaesthesia. Br J Anaesth 54:893–894

    CAS  PubMed  Google Scholar 

  49. Fisher MM, Graham R (1984) Adverse responses to local anaesthetics. Anaesth Intensive Care 12:325–327

    CAS  PubMed  Google Scholar 

  50. Fisher AA (1989) Reactions to injectable local anesthetics. Part IV: Reactions to sulfites in local anesthetics. Cutis 44:283–284

    CAS  PubMed  Google Scholar 

  51. Foldes FF, Davidson GM, Duncalf D, Kuwabara S (1965) The intravenous toxicity of local anesthetic agents in man. Clin Pharmacol Ther 6:328–335

    CAS  PubMed  Google Scholar 

  52. Frerichs RL, Campbell J, Bassell GM (1988) Psychogenic cardiac arrest during extensive sympathetic blockade. Anesthesiology 68:943–944

    CAS  PubMed  Google Scholar 

  53. Garner L, Stirt JA, Finholt DA (19856) Heart block after intravenous Udocaine in an infant. Can Anesth Soc J 32:425–428

    CAS  Google Scholar 

  54. Gissen AJ, Leith DE (1985) Transient decreases in respiratory rate following epidural injections. Anesthesiology 62:822–824

    CAS  PubMed  Google Scholar 

  55. Gould DB, Aldrete JA (1983) Bupivacaine cardiotoxicity in a patient with renal failure. Acta Anaesthesiol Scand 27:18–21

    CAS  PubMed  Google Scholar 

  56. Greene NM (1983) Uptake and elimination of local anesthetics during spinal anesthesia. Anesth Analg 62:1013–1024

    CAS  PubMed  Google Scholar 

  57. Gribomont BF (1988) Sudden complications in regional anesthesia. Acta Anaesthesiol Belg 39 (Supp1 2):165–170

    CAS  PubMed  Google Scholar 

  58. Grimes DA, Cates W (1976) Deaths from paracervical anesthesia used for first trimester abortions (1972–1975) N Engl J Med 29:1397–1399

    Google Scholar 

  59. Hamilton RC (1985) Brain stem anesthesia following retrobulbar blockade. Anesthesiology 63:688–690

    CAS  PubMed  Google Scholar 

  60. Heath ML (1982) Deaths after intravenous regional anaesthesia. Br Med J 285:913–914

    CAS  Google Scholar 

  61. Hempel V, Lenz G (1982) Lokalanästhetika — Wirkungsweise, Eigenschaften, Pharmakokinetik und Toxizität. Anästh Intensivmed 23:337–345

    Google Scholar 

  62. Hille B (1977) Ionic channels of nerve: questions for the theoretical chemist. Biosystems 8:195–199

    CAS  PubMed  Google Scholar 

  63. Holmboe J, Kongsgrud F (1982) Delayed respiratory arrest after bupivacaine. Anaesthesia 37:60–62

    CAS  PubMed  Google Scholar 

  64. Hondeghem LM, Katzung BG (1984) Antiarrhythmic agents: the modulated receptor mechanism of actions of sodium and calcium channel-blocking drugs. Annu Rev Pharmacol Toxicol 24:387–423

    CAS  PubMed  Google Scholar 

  65. Howie MB, Mortimer W, Candler EM, McSweeney TD, Frolicher DA (1989) Does nifedipine enhance the cardovascular depressive effects of bupivacaine? Regional Anesthesia 14:19–25

    CAS  PubMed  Google Scholar 

  66. Johnson WT, DeStigter T (1983) Hypersensitivity to procaine, tetracaine, mepivacaine, methylparaben: report of a case. J Am Dent Assoc 106:53–56

    CAS  PubMed  Google Scholar 

  67. des Jong RH, Bonin JD (1981) Mixtures of local anesthetics are no more toxic than the parent drugs. Anesthesiology 54:177–181

    PubMed  Google Scholar 

  68. Jorfeldt L, Lofstrom B, Pernow B, Persson B, Wahren J, Widman B (1968) The effect of local anaesthetics on the central circulation and respiration in man and dog. Acta Anaesthesiol Scand 12:153–169

    CAS  PubMed  Google Scholar 

  69. Knitza R, Sirtl C, Wisser J, Rhein R, Fischer B (1988) Zerebraler Krampfanfall nach Periduralanästhesie mit Bupivacain zur Sectio caesarea. Geburtshilfe Frauenheilkd 48:47–49

    CAS  PubMed  Google Scholar 

  70. Kreutz RW, Kinni ME (1983) Life-threatening toxic methemoglobinemia induced by prilocaine. Oral Surg Oral Med Oral Pathol 56:480–482

    CAS  PubMed  Google Scholar 

  71. Lauckner ME (1982) Delayed respiratory arrest after bupivacaine. Anaesthesia 37:697

    CAS  PubMed  Google Scholar 

  72. Lehmann KA (1986) Pharmakokinetische und -dynamische Aspekte bei der repetitiven Anwendung von Lokalanästhetika. In: Hempelmann G, Biscoping J (Hrsg) Kontinuierliche Verfahren der Regionalanästhesie. Astra Chemicals, S. 7–26

    Google Scholar 

  73. Lehmann KA (1990) Lokalanästhetika: Allgemeine Pharmakologie. In: Lehmann KA (Hrsg) Der postoperative Schmerz. Bedeutung, Diagnose und Behandlung. Springer,Berlin, S. 267–279

    Google Scholar 

  74. Leighton BL, Norris MC, Sosis M, Epstein R, Chayen B, Larijani GE (1987) Limitations of epinephrine as a marker of intravascular injection in laboring women. Anesthesiology 66:688–691

    CAS  PubMed  Google Scholar 

  75. Long WB, Rosenblum S, Grady IP (1989) Successful resuscitation of bupivacaine-induced cardiac arrest using cardiopulmonary bypass. Anesth Analg 69:403–406

    CAS  PubMed  Google Scholar 

  76. Ludwig SC (1981) Acute toxic methemoglobinemia following dental analgesia. Ann Emerg Med 10:265–266

    CAS  PubMed  Google Scholar 

  77. Lumb AB, Carli F (1989) Respiratory arrest after a caudal injection of bupivacaine. Anaesthesia 44:324–325

    CAS  PubMed  Google Scholar 

  78. Mallampati SR, Liu PL, Knapp RM (1984) Convulsions and ventricular tachycardia from bupivacaine with epinephrine: successful resuscitation. Anesth Analg 63:856–859

    CAS  PubMed  Google Scholar 

  79. Mather LE, Tucker GT, Murphy TM, Stanton-Hicks MDA, Bonica JJ (1979) Cardiovascular and subjective central nervous system effects of long-acting local anaesthetics in man. Anaesth Intensive Care 7:215–221

    CAS  PubMed  Google Scholar 

  80. Mather LE, Nacarrow C, Runciman WB (1990) Lokalanästhetika: Systemische Wirkungen. In: Lehmann KA (Hrsg) Der postoperative Schmerz. Springer, Berlin, S. 280–299

    Google Scholar 

  81. McGuigan MA (1981) Benzocaine-induced methemoglobinemia. Can Med Assoc J 125:816

    CAS  PubMed Central  PubMed  Google Scholar 

  82. McKeown DW, Meiklejohn B, Scott DB (1984) Bupivacaine and prilocaine in intravenous regional anaesthesia. Anaesthesia 39:150–154

    CAS  PubMed  Google Scholar 

  83. Mercereau Da (1989) Brain-stem anesthesia complicating retrobulbar block. Can J Ophthalmol 24:159–161

    CAS  PubMed  Google Scholar 

  84. Minasian A, Yagiela JA (1988) The use of local anesthetics in patients susceptible to malignant hyperthermia. Oral Surg 66:405–415

    CAS  PubMed  Google Scholar 

  85. Modica PA,Tempelhoff R,White PF (1990) Pro- and anticonvulsant effects of anesthetics (part II). Anesth Analg 70:433–44

    CAS  PubMed  Google Scholar 

  86. Moore DC, Bridenbaugh LD, Bridenbaugh PO, Thompson GE,Tucker GT (1972) Does compounding of local anesthetic agents increase their toxicity in humans? Anesth Analg 51:579–585

    CAS  PubMed  Google Scholar 

  87. Moore DC, Bridenbaugh LD, Thompson GE, Balfour RI, Horton WG (1978) Bupivacaine: a review of 11,080 cases. Anesth Analg 57:42–53

    CAS  PubMed  Google Scholar 

  88. Moore DC, Crawford RD, Scurlock J (1980) Severe hypoxia and acidosis following local anesthetic-induced convulsions. Anesthesiology 53:259–260

    CAS  PubMed  Google Scholar 

  89. Moore DC, Batra MS (1981) The components of an effective test dose prior to epidural block. Anesthesiology 55:693–696

    CAS  PubMed  Google Scholar 

  90. Moire DC, Spierdijk J, van Kleef JD, Coleman RL, Love GF (1982) Chloroprocaine neurotoxicity: four additional cases. Anesth Analg 61:155–159

    Google Scholar 

  91. Moore DC, Scurlock JE (1983) Possible role of epinephrine in prevention or correction of myocardial depression associated with bupivacaine. Anesth Analg 62:450–453

    CAS  PubMed  Google Scholar 

  92. Moore DC, Bonica JJ (1985) Convulsions and ventricular tachycardia from bupivacaine and epinephrine: successful resuscitation — congratulations! Anesth Analg 64:844–846

    CAS  PubMed  Google Scholar 

  93. Nancarrow C, Mather LE, Runciman WB, Upton RN, Plummer JL (1987) The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of the sheep. Anesth Analg 66:925–935

    CAS  PubMed  Google Scholar 

  94. Nicoll JM, Acharya PA, Ahlen K, Baguneid S, Edge KR (1987) Central nervous system complications after 600 retrobulbar blocks. Anesth Analg 66:1298–1302

    CAS  PubMed  Google Scholar 

  95. Nolte H (1986) Zur Problematik der Cardiotoxizität von Bupivacain 0,75 %. Reg Anaesth 9:57–59

    CAS  PubMed  Google Scholar 

  96. O’Donohue WJ, Moss LM, Angelillo VA (1980) Acute methemoglobinemia induced by topical benzocaine and lidocaine. Arch Int Med 140:1508–1509

    Google Scholar 

  97. Olthoff D,Vetter B, Deutrich C, Burkhardt U (1989) Pharmakokinetische Untersuchungen zu den Ursachen der erhöhten Neurotoxizität des Lidocains während kardiochirur-gischer Operationen. Anaesthesiol Reanimat 14:207–214

    CAS  Google Scholar 

  98. Parish RC, Moore RT, Gotz VP (1985) Seizures following oral lidocaine for esophageal anesthesia. Drug Intell Clin Pharm 19:199–201

    CAS  PubMed  Google Scholar 

  99. Park WY (1988) Factors influencing distribution of local anesthetics in the epidural space. Regional Anesthesia 13:49–57

    CAS  Google Scholar 

  100. Patel D, Chopra S, Berman MD (1989) Serious systemic toxicity from use of tetracaine for pharyngeal anesthesia in upper endoscopic procedures. Dig Dis Sci 34:882–884

    CAS  PubMed  Google Scholar 

  101. Pedersen H, Finster M (1987) Selection and use of local anesthetics. Clin Obstet Gynecol 30:505–514

    CAS  PubMed  Google Scholar 

  102. Perkins WJ, Lainer WL, Sharbrough FW (1988) Cerebral and hemodynamic effects of lidocaine accidentally injected into the carotid arteries of patients having carotid endarterectomy. Anesthesiology 69:787–790

    PubMed  Google Scholar 

  103. Prentiss (1979) Cardiac arrest following caudal anesthesia. Anesthesiology 50:51–53

    CAS  PubMed  Google Scholar 

  104. Raj PP, Winnie AP (1983) Immediate reactions to local anesthetics. In: Orkin FK, Cooperman LH (eds) Complications in anesthesiology. J.B. Lippincott, Philadelphia, Toronto, pp.51–74

    Google Scholar 

  105. Ravindran RS, Bond VK,Tasch MD, Gupta CD, Luerssen TG (1980) Prolonged neural blockade following regional analgesia with 2-chloroporcaine. Anesth Analg 59:447–451

    CAS  PubMed  Google Scholar 

  106. Reisner LS, Hochman BN, Plumer MH (1980) Persistent neurologic deficit and adhesive arachnoiditis following intrathecal 2-chloroprocaine injection. Anesth Analg 59:452–454

    CAS  PubMed  Google Scholar 

  107. Reiz S, Nath S (1986) Cardiotoxicity of local anaesthetic agents. Br J Anaesth 58:736–746

    CAS  PubMed  Google Scholar 

  108. Reynolds F (1971) A comparison of the potential toxicity of bupivacaine, lignocaine and mepivacaine during epidural blockade for surgery. Br J Anaesth 43:567–572

    CAS  PubMed  Google Scholar 

  109. Reynolds F (1987) Adverse effects of local anaesthetics. Br J Anaesth 59:78–95

    CAS  PubMed  Google Scholar 

  110. Riley RH (1990) Respiratory arrest following interpleural block in a narcotized patient. Can J Anaesth 37:487–488

    CAS  PubMed  Google Scholar 

  111. Romano E, Gullo A (1980) Hypoglycaemic coma following epidural analgesia. Anaesthesia 35:1084–1086

    CAS  PubMed  Google Scholar 

  112. Rosen PJ, Johnson C, McGethee WG, Beutler E (1971) Failure of methylene blue treatment in toxic methemoglobinemia. Association with glucose-6-phosphate dehydrogenase deficiency. Ann Intern Med 75:83–86

    CAS  PubMed  Google Scholar 

  113. Rosenberg PH, Kalso EA,Tuominen MK, Linden HB (1983) Acute bupivacaine toxicity as a result of various leakage under the tourniquet cuff of Bier block. Anesthesiology 58:95–98

    CAS  PubMed  Google Scholar 

  114. Ruzicka T, Gerstmeier M, Ring J (1986) Lokalanästhetika-Allergic. Z Hautkrankh 62:455–460

    Google Scholar 

  115. Sage D, Feldman HS, Datta S, Covino BG (1982) Influence of lidocaine and bupivacaine on isolated guinea pig atria in the presence of acidosis and hypoxia. Anesthesiology 57:A197

    Google Scholar 

  116. Schnorr C, Menges T, Hempelman G (1990) Lokalanästhetika-Mischungen bei verschiedenen Verfahren der Regionalanästhesie. Anaesth Intensivther Notfallmed 25:193–197

    CAS  Google Scholar 

  117. Scott DB, Davie IT, Stephen GW (1971) Cardiovascular effects of intravenous lignocaine during nitrous oxide/halothane anaesthesia. Br J Anaesth 43:595–599

    CAS  PubMed  Google Scholar 

  118. Scott DB (1986) Toxic effects of local anaesthetic agents on the central nervous system. Br J Anaesth 58:732–735

    CAS  PubMed  Google Scholar 

  119. Scott DB (1989) „Maximum recommended doses“ of local anaesthetic drugs. Br J Anaesth 63:373–374

    CAS  PubMed  Google Scholar 

  120. Scott DB, Lee A, Fagan D, Bowler GMR, Bloomfield P, Lundh R (1989) Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth Analg 69:563–569

    CAS  PubMed  Google Scholar 

  121. Sghirlanzoni A, Marazzi R, Pareyson D, Olivieri A, Bracchi M (1989) Epidural anaesthesia and spinal arachnoiditis. Anaesthesia 44:317–321

    CAS  PubMed  Google Scholar 

  122. de Shazo RD, Nelson HS (1979) An approach to the patient with a history of local anaesthetic hypersensitivity: experience with 90 patients. J Allergy Clin Immunol 63:387

    Google Scholar 

  123. Smith AR, Hur D, Resano F (1987) Grand mal seizures after 2-chloroprocaine epidural anesthesia in a patient with plasma Cholinesterase deficiency. Anesth Analg 66:677–678

    CAS  PubMed  Google Scholar 

  124. Spielman FJ, Anderson JA, Terry WC (1984) Benzocaine induced methemoglobinemia during general anesthesia. J Oral Maxillofac Surg 42:740–743

    CAS  PubMed  Google Scholar 

  125. Sundaram MBM (1987) Seizures after intraurethral instillation of lidocaine. Can Med Assoc J 137:219–220

    CAS  Google Scholar 

  126. Sunshine I, Fike WW (1964) Value of thin-layer chromatography in two fatal cases of intoxication due to lidocaine and mepivacaine. N Engl J Med 271:487–490

    CAS  PubMed  Google Scholar 

  127. Thiessen F, Bergmann J, Steinhoff H (1984) Methämoglobinämie nach Blockade des Plexus brachialis mit Prilocain (Xylonest). Reg Anaesth 7:94–95

    CAS  PubMed  Google Scholar 

  128. Tryba M, Kurth H, Zenz M (1987) Klinische und toxikologische Untersuchung zur axillären Plexusblockade mit Prilocain oder Mepivacain. Reg Anaesth 10:31–36

    CAS  PubMed  Google Scholar 

  129. Tryba M, Börner P (1988) KUnische Wirksamkeit und Systemtoxizität verschiedener Mischungen von Prilocain und Bupivacain zur axillären Plexusblockade. Reg Anaesth 11:40–49

    CAS  PubMed  Google Scholar 

  130. Tucker GT, Mather LE (1975) Pharmacokinetics of local anaesthetic agents. Br J Anaesth 47:213–224

    PubMed  Google Scholar 

  131. Tucker GT, Mather LE (1979) Clinical pharmacokinetics of local anaesthetics. Clin Pharmacokinet 4:242–278

    Google Scholar 

  132. Tucker GT, Mather LE (1980) Absorption and disposition of local anesthetics: pharmacokinetics. In: Cousins MJ, Bridenbaugh PO (eds) Neural blockade m clinical anesthesia and management of pain. J.B. Lippincott, Philadelphia, Toronto, pp. 45–85

    Google Scholar 

  133. Veraiquet AJW (1980) Vessel puncture with epidural catheters. Experience in obstetric patients. Anaesthesia 35:660–662

    Google Scholar 

  134. Wehner D, Hamilton GL (1984) Seizures following topical administration of local anesthetic to burn patients. Ann Emerg Med 13:456–458

    CAS  PubMed  Google Scholar 

  135. Wilson G, Borthwick T, Lamb R (1989) Toxic methemoglobinemia. J Tenn Med Assoc 82:581–583

    CAS  PubMed  Google Scholar 

  136. Yaster M, Maxwell LG (1989) Pediatric regional anesthesia. Anesthesiology 70:324–338

    CAS  PubMed  Google Scholar 

  137. Zundert A van,Vaes L, Soetens M, de Vel M, van der Aa, van der Donck, Meeuwis H, de Wolf A (1987) Every dose given in epidural analgesia for vaginal delivery can be a test dose. Anesthesiology 67:436–440

    PubMed  Google Scholar 

  138. Zundert A van, Vaes L, Soertens M, des Wolf A (1988) Indentification of inadvertent intravenous placement of an epidural catheter in obstetric anesthesia. Anesthesiology 68:142–145

    PubMed  Google Scholar 

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  1. Institut für Anaesthesiologie, Universität Erlangen-Nürnberg, Krankenhausstr. 12, D-W-8520, Erlangen, Germany

    E. Rügheimer Prof. Dr. med.

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© 1993 Springer-Verlag Berlin Heidelberg

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Lehmann, K.A. (1993). Zwischenfälle bei der Anwendung von Lokalanästhetika. In: Rügheimer, E. (eds) Konzepte zur Sicherheit in der Anästhesie. Klinische Anästhesiologie und Intensivtherapie, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77781-3_17

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  • DOI: https://doi.org/10.1007/978-3-642-77781-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55931-3

  • Online ISBN: 978-3-642-77781-3

  • eBook Packages: Springer Book Archive

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