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Cytochrome P450 pp 627–639Cite as

Lanosterol 14α-Demethylase (Cytochrome P45014DM)

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 105))

Abstract

Lanosterol 14α-demethylase (cytochrome P45014DM) is a housekeeping enzyme occurring widely in eukaryotes. It is a cytochrome P450 mono-oxygenase catalyzing the conversion of lanosterol or 24,25-dihydrolanosterol (DHL) to the 14-demethylated and 14,15-desaturated derivatives by removing the 14α-methyl group (C32) as formic acid (Fig. 1) (Watkinson and Akhtar 1969; Alexander et al. 1972; Gibbons and Mitropoulos 1973; Mitropoulos et al. 1976; Aoyama and Yoshida 1978; Aoyama et al. 1984; Trzaskos et al. 1986). The 14α-demethylation is an essential reaction of steroid biosynthesis by eukaryotes, because most of the functional steroids have no 14-methyl group.

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Authors
  1. Y. Yoshida
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Editors and Affiliations

  1. Department of Pharmacology, MC 1505, University of Connecticut Health Center, 263 Farmington Avenue, 06030, Farmington, CT, USA

    John B. Schenkman Ph.D.

  2. Institut für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung mbH, Ingolstädter Landstr. 1, W-8042, Neuherberg, Fed. Rep. of Germany

    Helmut Greim M.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Yoshida, Y. (1993). Lanosterol 14α-Demethylase (Cytochrome P45014DM). In: Schenkman, J.B., Greim, H. (eds) Cytochrome P450. Handbook of Experimental Pharmacology, vol 105. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77763-9_40

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  • DOI: https://doi.org/10.1007/978-3-642-77763-9_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77765-3

  • Online ISBN: 978-3-642-77763-9

  • eBook Packages: Springer Book Archive

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