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Cholesterol 7α-Hydroxylase and 12α-Hydroxylase

  • K. Okuda
  • T. Ogishima
  • M. Noshiro
Chapter
  • 379 Downloads
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 105)

Abstract

Three major cytochrome P450 enzymes are involved in the conversion of cholesterol into bile acids, i.e., cholesterol 7α-hydroxylase (EC 1.14.13.17), 12α-hydroxylase and 5β-cholestane-3α,7α,12α-triol 27-hydroxylase (EC 1.14.13.15) of which cholesterol 7α-hydroxylase catalyzes a rate-limiting step for overall conversion, whereas 12α-hydroxylase seems to regulate the relative amount of cholic acid over chenodeoxycholic acid (Björkhem 1985). 27-Hydroxylase catalyzes the hydroxylation of one of the terminal methyl groups of 5β-cholestane-3α,7α,12α-triol and 5β-cholestane-3α,7α-diol. In this chapter cholesterol 7α-hydroxylase and 12α-hydroxylase are reviewed. These two hydroxylases modify the steroid nucleus (Fig. 1). The cytochrome P450 species involved in side chain oxidation is reviewed elsewhere in this book by Wikvall (see Chap. 46).

Keywords

Bile Acid Cholic Acid Chenodeoxycholic Acid Amino Glutethimide Cytochrome P450 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • K. Okuda
  • T. Ogishima
  • M. Noshiro

There are no affiliations available

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