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Regulation of Cytochrome P450 Expression

  • K. Sogawa
  • Y. Fujii-Kuriyama
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 105)

Abstract

Biosynthesis of almost all forms of cytochrome P450 is affected by extra-cellular effectors including steroid and peptide hormones. In particular, a group of drug-metabolizing cytochromes P450 is strongly induced by treatment with foreign compounds such as drugs, insecticides, carcinogens, and environmental pollutants. The molecular mechanism of signal transduction evoked by the effectors has been poorly understood, although the signal was in most cases targeted at the transcriptional level (Gotoh and Fujii-Kuriyama 1989; Whitlock 1986; Adesnik and Atchison 1985).

Keywords

Inducible Expression Cytochrome P450 Gene Steroid Hormone Receptor Superfamily Xenobiotic Responsive Element Cytochrome P450 Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adesnik M, Atchison M (1985) Genes for cytochrome P-450 and their regulation. Crit Rev Biochem 19: 247–305CrossRefGoogle Scholar
  2. Bradfield CA, Glover E, Poland A (1991) Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse. Mol Pharmacol 39: 13–19PubMedGoogle Scholar
  3. Cuthill S, Wilhelmsson A, Poellinger L (1991) Role of the ligand in intracellular receptor function: receptor affinity determines activation in vitro of the latent dioxin receptor to a DNA-binding form. Mol Cell Biol 11: 401–411PubMedGoogle Scholar
  4. Denis M, Cuthill S, Wikstrom A-C, Poellinger L, Gustafsson J-A (1988) Association of the dioxin receptor with the Mr 90000 heat shock protein: a structural kinship with the glucocorticoid receptor. Biochem Biophys Res Commun 155: 801–807PubMedCrossRefGoogle Scholar
  5. Denison MS, Fisher JM, Whitlock JP Jr (1988) The DNA recognition site for the dioxin-Ah receptor complex. J Biol Chem 263: 17221–17224PubMedGoogle Scholar
  6. Fisher JM, Wu L, Denison MS, Whitlock JP Jr (1990) Organization and function of a dioxin-responsive enhancer. J Biol Chem 265: 9676–9681PubMedGoogle Scholar
  7. Fujisawa-Sehara A, Sogawa K, Nishi C, Fujii-Kuriyama Y (1986) Regulatory DNA elements localized remotely upstream from the drug-metabolizing cytochrome P-450c gene. Nucleic Acids Res 14: 1465–1477PubMedCrossRefGoogle Scholar
  8. Fujisawa-Sehara A, Sogawa K, Yamane M, Fujii-Kuriyama Y (1987) Characterization of xenobiotic responsive elements upstream from the drug- metabolizing cytochrome P-450c gene: a similarity to glucocorticoid regulatory elements. Nucleic Acids Res 15: 4179–4191PubMedCrossRefGoogle Scholar
  9. Fujisawa-Sehara A, Yamane M, Fujii-Kuriyama Y (1988) A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: its possible translocation to nucleus. Proc Natl Acad Sci USA 85: 5859–5863PubMedCrossRefGoogle Scholar
  10. Gonzalez FJ, Nebert DW (1985) Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse Pr450 gene. Nucleic Acids Res 13: 7269–7288PubMedCrossRefGoogle Scholar
  11. Gonzalez FJ, Kimura S, Nebert DW (1985) Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome Pr450 and P3-450 genes. J Biol Chem 260: 5040–5049PubMedGoogle Scholar
  12. Gotoh O, Fujii-Kuriyama Y (1989) Evolution, structure, and gene regulation of cytochrome P-450. In: Ruckpaul K, Rein H (eds) Frontiers in biotransformation, vol 1. Akademie, Berlin, pp 195–243Google Scholar
  13. Hapgood J, Cuthill S, Denis M, Poellinger L, Gustafsson J-A (1989) Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity. Proc Natl Acad Sci USA 86: 60–64PubMedCrossRefGoogle Scholar
  14. Hashimoto T, Matsumoto T, Nishizawa M, Kawabata S, Morohashi K, Handa S, Omura T (1988) A mutant rat strain defficient in induction of a phenobarbital-inducible form of cytochrome P-450 in liver microsomes. J Biochem (Tokyo) 103: 487–492Google Scholar
  15. Hines RN, Mathis JM, Jacob CS (1988) Identification of multiple regulatory elements on the human cytochrome P450IA1 gene. Carcinogenesis 9: 1599–1605PubMedCrossRefGoogle Scholar
  16. Hoffman EC, Reyes H, Chu F-F, Sander F, Conley LH, Brooks BA, Hankinson O (1991) Cloning of a factor required for activity of the Ah ( Dioxin) receptor. Science 252: 954–958PubMedCrossRefGoogle Scholar
  17. Imataka H, Sogawa K, Yasumoto K, Kikuchi Y, Sasano K, Kobayashi A, Hayami M, Fujii-Kuriyama Y (1992) Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. EMBO J 11: 3663–3671PubMedGoogle Scholar
  18. Issemann I, Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347: 645–650PubMedCrossRefGoogle Scholar
  19. Johnson EF, Walker DL, Griffin KJ, Clark JE, Okita RT, Muerhoff AS, Masters BS (1990) Cloning and expression of three rabbit kidney cDNAs encoding lauric acid co-hydroxylases. Biochemistry 29: 873–879PubMedCrossRefGoogle Scholar
  20. Jones PBG, Galeazzi DR, Fisher JM, Whitlock JP Jr (1985) Control of cytochrome Pr450 gene expression by dioxin. Science 227: 1499–1502PubMedCrossRefGoogle Scholar
  21. Kubota M, Sogawa K, Kaizu Y, Sawaya T, Watanabe J, Kawajiri K, Gotoh O, Fujii-Kuriyama Y (1991) Xenobiotic responsive element in the 5′-upstream region of the human P-450c gene. J Biochem (Tokyo) 110: 232–236Google Scholar
  22. Mathis JM, Houser WB, Bresnick E, Cidlowski JA, Hines RN, Prough RA, Simpson ER (1989) Glucocorticoid regulation of the rat cytochrome P450c(P450IAl) gene: receptor binding within intron I. Arch Biochem Biophys 269: 93–105PubMedCrossRefGoogle Scholar
  23. Mizukami Y, Sogawa K, Suwa Y, Muramatsu M, Fujii-Kuriyama Y (1983) Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver. Proc Natl Acad Sci USA 80: 3958–3962PubMedCrossRefGoogle Scholar
  24. Morgan ET, MacGeoch C, Gustafsson J-A (1985) Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16a-hydroxylase cytochrome P-450 apoprotein in the rat. J Biol Chem 260: 11895–11898PubMedGoogle Scholar
  25. Neuhold LA, Shirayoshi Y, Ozato K, Jones JE, Nebert DW (1989) Regulation of mouse CYPIA1 gene expression by dioxin: requirement of two cis-acting elements during induction. Mol Cell Biol 9: 2378–2386PubMedGoogle Scholar
  26. Noshiro M, Negishi M (1986) Pretranslational regulation of sex-dependent testosterone hydroxylases by growth hormone in mouse liver. J Biol Chem 261: 15923–15927PubMedGoogle Scholar
  27. Omiecinski CJ (1986) Tissue-specific expression of rat mRNAs homologous to cytochrome P-450b and P-450e. Nucleic Acids Res 14: 1525–1539PubMedCrossRefGoogle Scholar
  28. Perdew GH (1988) Association of the Ah receptor with the 90-kDa heat shock protein. J Biol Chem 263: 13802–13805PubMedGoogle Scholar
  29. Quattrochi LC, Tukey RH (1989) The human cytochrome CyplA2 gene contains regulatory elements responsive to 3-methylcholanthrene. Mol Pharmacol 36: 66–71PubMedGoogle Scholar
  30. Rangarayan PN, Padmanaban G (1989) Regulation of cytochrome P-450b/e gene expression by a heme- and phenobarbitone-modulated transcription factor. Proc Natl Acad Sci USA 86: 3963–3967CrossRefGoogle Scholar
  31. Saaticioglu F, Perry DJ, Pasco DS, Fagan JB (1990a) Aryl hydrocarbon ( Ah) receptor DNA-binding activity. J Biol Chem 265: 9251–9258Google Scholar
  32. Saaticioglu F, Perry DJ, Pasco DS, Fagan JB (1990b) Multiple DNA-binding factors interact with overlapping specificities at the aryl hydrocarbon response element of the cytochrome P450IA1 gene. Mol Cell Biol 10: 6408–6416Google Scholar
  33. Schuetz EG, Li D, Omiecinski DJ, Muller-Eberhard U, Kleinman HK, Elswick B, Guzelian PS (1988) Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix. J Cell Physiol 134: 309–323PubMedCrossRefGoogle Scholar
  34. Sogawa K, Gotoh O, Kawajiri K, Harada T, Fujii-Kuriyama Y (1985) Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450(P- 450d) gene in the rat. J Biol Chem 260: 5026–5032PubMedGoogle Scholar
  35. Sogawa K, Fujisawa-Sehara A, Yamane M, Fujii-Kuriyama Y (1986) Location of regulatory elements responsible for drug induction in the rat cytochrome P-450c gene. Proc Natl Acad Aci USA 83: 8044–8048CrossRefGoogle Scholar
  36. Suwa Y, Mizukami Y, Sogawa K, Fujii-Kuryama Y (1985) Gene structure of a major form of phenobarbital-inducible cytochrome P-450 in rat liver. J Biol Chem 260: 7980–7984PubMedGoogle Scholar
  37. Traber PG, Chianale J, Florence R, Kim K, Wojcik E, Gumcecio JJ (1988) Expression of cytochrome P-450b and P-450e genes in small interstinal mucosa of rats following treatment with phénobarbital, polyhalogenated biphenyls, and organochloride pesticides. J Biol Chem 263: 9449–9455PubMedGoogle Scholar
  38. Wen L-P, Koeiman N, Whitlock JP Jr (1990) Dioxin-inducible, Ah receptor-dependent transcription in vitro. Proc Natl Acad Sci USA 87: 8545–8549PubMedCrossRefGoogle Scholar
  39. Whitlock JP Jr (1986) The regulation of cytochrome P-450 gene expression. Annu Rev Pharmacol Toxicol 26: 333–369PubMedCrossRefGoogle Scholar
  40. Wilhelmsson A, Cuthill S, Denis M, Wikström A-C, Gustafsson J-Å, Poellinger L (1990) The specific DNA binding activity of the dioxin receptor is modulated by the 90kd heat shock protein. EMBO J 9: 69–76PubMedGoogle Scholar
  41. Yamazoe Y, Shimada M, Murayama N, Kato R (1987) Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. J Biol Chem 262: 7423–7428PubMedGoogle Scholar
  42. Yanagida A, Sogawa K, Yasumoto K, Fujii-Kuriyama Y (1990) A novel ds-acting DNA element required for a high level of inducible expression of the rat P-450c gene. Mol Cell Biol 10: 1470–1475PubMedGoogle Scholar
  43. Yokotani N, Bernhardt, R, Sogawa K, Kusunose E, Gotoh O, Kusunose M, Fujii- Kuriyama Y (1989) Two forms of co-hydroxylase toward prostaglandin A and laurate: cDNA cloning and their expression. J Biol Chem 264: 21665–21669PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • K. Sogawa
  • Y. Fujii-Kuriyama

There are no affiliations available

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