Regulation of Cytochrome P450 Expression
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Biosynthesis of almost all forms of cytochrome P450 is affected by extra-cellular effectors including steroid and peptide hormones. In particular, a group of drug-metabolizing cytochromes P450 is strongly induced by treatment with foreign compounds such as drugs, insecticides, carcinogens, and environmental pollutants. The molecular mechanism of signal transduction evoked by the effectors has been poorly understood, although the signal was in most cases targeted at the transcriptional level (Gotoh and Fujii-Kuriyama 1989; Whitlock 1986; Adesnik and Atchison 1985).
KeywordsInducible Expression Cytochrome P450 Gene Steroid Hormone Receptor Superfamily Xenobiotic Responsive Element Cytochrome P450 Expression
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