Changes in Cytochrome P450 in Senescence

  • L. S. Birnbaum
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 105)


Approximately 20% of the population in developed countries is over the age of 65 years. The elderly not only represent the fastest growing segment of the population, but are also the heaviest consumers of drugs. The elderly are particularly sensitive to the adverse effects of drugs, and the extensive use of medications makes the possibility of multiple drug reactions extremely likely. In addition, the aged may represent a population at special risk to environmental toxicants as well as drugs. The enhanced sensitivity of the elderly to drugs and environmental insults has been the subject of several recent reviews (Vestal and Dawson 1985; Birnbaum 1990, 1991).


Hepatic Drug Metabolism Cytochrome P450 Activity Cytochrome P450 Content Aniline Hydroxylase Specific Cytochrome 
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© Springer-Verlag Berlin Heidelberg 1993

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  • L. S. Birnbaum

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