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Changes in Cytochrome P450 in Senescence

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Cytochrome P450

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 105))

Abstract

Approximately 20% of the population in developed countries is over the age of 65 years. The elderly not only represent the fastest growing segment of the population, but are also the heaviest consumers of drugs. The elderly are particularly sensitive to the adverse effects of drugs, and the extensive use of medications makes the possibility of multiple drug reactions extremely likely. In addition, the aged may represent a population at special risk to environmental toxicants as well as drugs. The enhanced sensitivity of the elderly to drugs and environmental insults has been the subject of several recent reviews (Vestal and Dawson 1985; Birnbaum 1990, 1991).

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Authors
  1. L. S. Birnbaum
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Editors and Affiliations

  1. Department of Pharmacology, MC 1505, University of Connecticut Health Center, 263 Farmington Avenue, 06030, Farmington, CT, USA

    John B. Schenkman Ph.D.

  2. Institut für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung mbH, Ingolstädter Landstr. 1, W-8042, Neuherberg, Fed. Rep. of Germany

    Helmut Greim M.D.

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Birnbaum, L.S. (1993). Changes in Cytochrome P450 in Senescence. In: Schenkman, J.B., Greim, H. (eds) Cytochrome P450. Handbook of Experimental Pharmacology, vol 105. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77763-9_31

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  • DOI: https://doi.org/10.1007/978-3-642-77763-9_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77765-3

  • Online ISBN: 978-3-642-77763-9

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