Hormonal Regulation of Cytochrome P450 in Rat Liver

  • R. Kato
  • Y. Yamazoe
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 105)


A number of lipophilic xenobiotics and endobiotics are biotransformed oxidatively by cytochrome P450 in mammalian livers. Many different forms of cytochrome P450 are contained in this organ and each shows a broad substrate specificity. Thus, cytochrome P450 has been considered as a family of polysubstrate enzymes, and we now know that cytochrome P450 constitutes a supergene family through the characterization of the purified proteins and cDNAs. These studies also provide information on the diversity in the regulatory mechanism of hepatic cytochromes P450: Some of these forms are expressed in age- and/or sex-related manners in livers of experimental animals, especially in rats (Kato 1974; Kato and Kamataki 1982). These differences are governed by sex steroids and other hormones. Changes in drug-metabolizing activities observed in physiological and pathological conditions are now recognized to be associated with an alteration in endocrine factors. In this section, the current understanding on the regulation and expression of sex-related cytochrome P450 forms in rat liver is reviewed.


Growth Hormone Thyroid Hormone Hepatic Cytochrome Hepatic Level Hepatic Microsomal Cytochrome 
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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • R. Kato
  • Y. Yamazoe

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