Cytochromes P450 in Genetically Engineered Cell Cultures: The Gene Technological Approach

  • J. Doehmer
  • H. Greim
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 105)


Molecular cloning of genes encoding cytochromes P450 followed by heterologous expression in various systems is being successfully applied in multi-faceted studies of cytochromes P450. The application of modern molecular biology techniques is especially indicated for complex systems such as the cytochromes P450 in order to sort out a particular isoform without the need for tedious purification.


Stable Expression P450 Reductase Human Cytochrome Cytochrome P450 Reductase Human Lymphoblastoid Cell Line 
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© Springer-Verlag Berlin Heidelberg 1993

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  • J. Doehmer
  • H. Greim

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