Extrahepatic Microsomal Forms: Brain Cytochrome P450

  • M. Warner
  • J.-Å. Gustafsson
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 105)


Both microsomal and mitochondrial forms of cytochrome P450 have been found in the brain. In addition to the estimation of the total amount of cytochrome P450 in the brain by its carbon monoxide difference spectrum, several specific forms of the enzyme have been detected by their catalytic activities, by immunohistochemical techniques and, in a few cases, the mRNA for some forms has been found by Northern blotting, or upon amplification with the polymerase chain reaction. This chapter will summarize what is known about the concentration, distribution, and regulation of brain cytochrome P450. We will also evaluate the evidence for the presence of known forms and for novel brain cytochromes P450, and will conclude with speculation about the physiological functions and possible toxicological consequences of brain cytochrome P450.


Olfactory Lobe Cytochrome P450 Content Brain Microsome Cerebrotendinous Xanthomatosis Work Environ Health 
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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • M. Warner
  • J.-Å. Gustafsson

There are no affiliations available

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