Cytochrome P450 Forms in Fish

  • J. J. Stegeman
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 105)


Recognition that cytochromes P450 play key roles in pharmacology, toxicology, carcinogenesis and endocrinology stimulated the drive to understand the diversity of forms, functions and regulation of these enzymes. Comparative biochemistry has played an essential role in cytochrome P450 research; the studies in rats, rabbits and mice are directed at understanding fundamental features that may also characterize these systems in humans. Such comparative studies are still vigorously pursued, although the study of cytochrome P450 in human systems has rightly acquired a vigor necessary for eventual application in a clinical setting.


Rainbow Trout Aryl Hydrocarbon Hydroxylase Microsomal Activity Rainbow Trout Liver Mammalian Cytochrome 
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© Springer-Verlag Berlin Heidelberg 1993

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  • J. J. Stegeman

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