Skip to main content
SpringerLink
Log in
Book cover

Cytochrome P450 pp 259–277Cite as

Avian Cytochrome P450

  • Chapter

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 105))

Abstract

The cytochromes P450 are a family of hemoproteins that function within a membrane-bound electron transport chain to catalyze the oxidation of many endogenous and exogenous chemicals. Cytochrome P450 has been found in a wide diversity of phyla ranging from eukaryotes to humans. In this review, we describe the forms of cytochrome P450 characterized in avian species, concentrating mainly on those expressed in chickens. Two recent reviews of avian cytochrome P450 document the many observations with domestic and wild birds especially as these pertain to environmental exposure to inducing chemicals (Ronis and Walker 1989a,b). Recent developments reviewed here include the isolation and enzymic characterization of several induced chicken forms and the regulation of expression of these forms. Comparison of the avian forms with those of mammalian species will allow a better understanding of the multiplicity of cytochromes P450 required for metabolism of both endogenous and exogenous chemicals.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abou-Donia M, Gupta R (1991) Ethanol induction of adult hen microsomal cytochrome P450 isozymes. Toxicologist 11: 170

    Google Scholar 

  • Ades I (1983) Identification and purification of a cytochrome P450 from livers of PB-treated chicken embryos. IRCS Med Sci 11: 302–303

    CAS  Google Scholar 

  • Althaus F, Meyer U (1981) Effects of phenobarbital, (3-naphthoflavone, dexamethasone and formamidoxamine on the turnover of inducible microsomal proteins in cultured hepatocytes. J Biol Chem 256: 13079–13084

    PubMed  CAS  Google Scholar 

  • Althaus F, Sinclair J, Sinclair P, Meyer U (1979) Drug-mediated induction of cytochromes P-450 and drug metabolism in cultured hepatocytes maintanined in a chemically defined medium. J Biol Chem 254: 2148–2153

    PubMed  CAS  Google Scholar 

  • Blanloeil Y, Deybach JC, Portier D, Joyau M, Nordman Y (1989) Anesthesia and hepatic porphyria. Ann Fr Anesth Reanim 8: 109–125

    Article  PubMed  CAS  Google Scholar 

  • Bleiberg J, Wallen M, Bradkin R, Applebaum I (1964) Industrially acquired porphyria. Arch Dermatol 89: 793–797

    Article  PubMed  CAS  Google Scholar 

  • Brooker J, O’Connor R (1982) cDNA cloning and analysis of chick embryo liver cytochrome P450 mRNA induced by porphyrinogenic drugs. Eur J Biochem 129: 325–333

    Google Scholar 

  • Burke M, Thompson S, Elcombe C, Halpert J, Haaparanta T, Mayer R (1985) Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P450. Biochem Pharmacol 34: 3337–3345

    Article  PubMed  CAS  Google Scholar 

  • Burnet F, Darby N (1984) Ethanol induces an aniline hydroxylase in chick embryo liver without inducing cytochrome P450. Biochem Soc Trans 12: 686

    CAS  Google Scholar 

  • Cornell N (1987) Pyrazoles as effectors of ethanol oxidizing enzymes and inducers of cytochrome P450. Alcohol Alcohol Sl: 251–255

    Google Scholar 

  • Darby N, Lodola A, Burnett F (1986) Testosterone metabolite profiles reveal differences in the spectrum of P450 induced by PB, AAF and MC in chick embryo liver. Biochem Pharmacol 35: 4073–4076

    Article  PubMed  CAS  Google Scholar 

  • DeMatteis F, Harvey C, Reed C, Hempenius R (1988) Increased oxidation of uroporphyrinogen by an inducible liver microsomal system. Possible relevance to drug-induced uroporphyria. Biochem J 250: 161–169

    CAS  Google Scholar 

  • Denison M, Okey A, Hamilton J, Bloom S, Wilkinson C (1986) Ah receptor for 2378-tetrachlorodibenzo-p-dioxin ontogeny in chick embryo liver. J Biochem Toxicol 1: 39–49

    Article  PubMed  CAS  Google Scholar 

  • de Verneuil H, Deybach JC, Phung N, Da Silva V, Nordmann Y (1983) Study of anaesthetic agents for their ability to elicit porphyrin biosynthesis in chick embryo liver. Biochem Pharmacol 15: 1011–1018

    Article  Google Scholar 

  • Drew P, Ades I (1989) Regulation of production of 5-aminolaevulinate synthase in tissues of chick embryos: effects of porphyrinogenic agents and of haem precursors. Biochem J 262: 815–821

    PubMed  CAS  Google Scholar 

  • Dutton J, Leakey J (1981) The perinatal development of drug-metabolizing enzymes: what factors trigger their onset. Prog Drug Res 25: 189–273

    PubMed  CAS  Google Scholar 

  • Dwarki V, Francis V, Bhat G, Padmanaban G (1987) Regulation of cytochrome P450 mRNA and apoprotein levels by heme. J Biol Chem 262: 16958–16962

    PubMed  CAS  Google Scholar 

  • Elder G (1990) The cutaneous porphyrias. Semin Dermatol 9: 63–39

    PubMed  CAS  Google Scholar 

  • Ghazarian J, Hsu P, Peterson B (1977) Chick kidney microsomal P450 involvement in the metabolism of 25-hydroxyvitamin D3. Arch Biochem Biophys 184: 596–604

    Article  PubMed  CAS  Google Scholar 

  • Giachelli C, Omiecinski C (1987) Developmental regulation of cytochrome P450 genes in the rat. Mol Pharmacol 31: 477–484

    PubMed  CAS  Google Scholar 

  • Granick S (1966) The induction in vitro of the synthesis of 5-aminolevulinic acid synthase in chemical porphyria: a response to certain drugs, sex hormones and foreign chemicals. J Biol Chem 241: 1359–1375

    PubMed  CAS  Google Scholar 

  • Gonzalez F (1989) The molecular biology of cytochrome P450s. Pharmacol Rev 40: 243–288

    Google Scholar 

  • Gupta R, Lapadula D, Abou-Donia M (1990a) Purification and characterization of cytochrome P450 isozymes from phenobarbital-induced adult hen liver. Comp Biochem Physiol [c] 96: 163–176

    Article  CAS  Google Scholar 

  • Gupta R, Lapadula D, Abou-Donia M (1990b) Purification and characterization of P450 isozymes from (3-naphthoflavone-induced adult hen liver. Arch Biochem Biophys 282: 170–182

    Article  PubMed  CAS  Google Scholar 

  • Hamilton J, Denison M, Bloom S (1983) Development of basal and induced aryl hydrocarbon benzo[a]pyrene hydroxylase activity in the chicken embryo in ovo. Proc Natl Acad Sci USA 80: 3372–3376

    Article  PubMed  CAS  Google Scholar 

  • Hamilton J, Bement W, Sinclair P, Sinxlair J, Wetterhahn K (1988) Expression of 5-aminolaevulinate synthase and cytochrome P450 mRNAs in chick embryo hepatocytes in vivo and in culture: effect of porphyrinogenic drugs and heme. Biochem J 255: 267–275

    PubMed  CAS  Google Scholar 

  • Hamilton J, Bement W, Sinclair P, Sinclair J, Alcedo J Wetterhahn K (1991) Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription. Arch Biochem Biophys 289: 387–392

    Article  PubMed  CAS  Google Scholar 

  • Hamilton J, Bement W, Sinclair P, Sinclair J, Alcedo J, Wetterhahn K (1992) Inhibition of protein synthesis increases the transcription of the phenobarbital- inducible CYP2H1 and CYP2H23 genes in chick embryo hepatocytes. Arch Biochem Biophys 298: 96–101

    Article  PubMed  CAS  Google Scholar 

  • Hahn C, Hansen A, May B (1991) Transcriptional regulation of the chicken CYP2H1 gene. J Biol Chem 266: 17031–17039

    PubMed  CAS  Google Scholar 

  • Hansch C, Sinclair J, Sinclair P (1990) Induction of cytochrome P450 by barbiturates in chick embryo hepatocytes: a quantitative structure-activity analysis. Quant Struct Act Relat 9: 223–226

    Article  CAS  Google Scholar 

  • Hansen A, May B (1989) Sequence of chicken phenobarbital-inducible P450 cDNA: regulation of two P450 mRNAs transcribed from different genes. DNA 8: 179–191

    Article  PubMed  CAS  Google Scholar 

  • He J, Fulco A (1919) A barbiturate-regulated protein binding to a common sequence in the cytochrome P450 genes of rodents and bacteria. J Biol Chem 266: 7864–7869

    Google Scholar 

  • Hobbs A, Mattschoss L, May B, Williams K, Elliott W (1986) The cDNA and protein sequence of a phenobarbital-induced chicken cytochrome P450. J Biol Chem 261: 9444–9449

    PubMed  CAS  Google Scholar 

  • Hokama Y, Koga N, Yoshimura H (1988) Purification and characterization of two forms of chicken liver cytochrome P450 induced by 3,4,5,3′,4′-penta- chlorobiphenyl. J. Biochem (Tokyo) 104: 355–361

    CAS  Google Scholar 

  • Imaoka S, Yoshitake T, Funae Y (1990) Changes in the amount of cytochrome P450s in rat hepatic microsomes with starvation. Arch Biochem Biophys 278: 168–178

    Article  PubMed  CAS  Google Scholar 

  • Jacobs J, Sinclair P, Bement J, Lambrecht R, Sinclair J, Goldstein J (1989) Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P450: essential role of cytochrome P450d. Biochem J 258: 247–253

    PubMed  CAS  Google Scholar 

  • Jacobs J, Sinclair P, Lambrecht R, Sinclair J, Jacobs N (1990) Role of inducer binding in cyochrome P450 lA2-mediated uroporphyrinogen oxidation. Biochem Toxicol 5: 193–199

    Article  CAS  Google Scholar 

  • Jackson M, Kennedy S, Lown G, Burchell B (1986) Induction of UDPglucuronyl transferase mRNA in embryonic chick livers by phenobarbital. Biochem Pharmacol 35: 1191–1198

    Article  PubMed  CAS  Google Scholar 

  • Johansson I, Ekstrom G, Scholte B, Puzycki D, Ingelman-Sundberg M (1988) Ethanol-, fasting- and acetone-inducible cytochromes P450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. Biochem 27: 1925–1934

    Article  CAS  Google Scholar 

  • Jones K, Sweeney G (1977) Association between induction of arylhydrocarbon hydroxylase activity and depression of uroporphyrinogen decarboxylase activity. Res Commun Chem Pathol Pharmacol 17: 631–637

    PubMed  CAS  Google Scholar 

  • Kim B, Fulco J (1983) Induction by barbiturates of a cytochrome P450-dependent fatty acid monooxygenase in Bacillus megaterium: relationship between barbiturate structure and inducing activity. Biochem Biophys Res Commun 116: 843–850

    Article  PubMed  CAS  Google Scholar 

  • Koop D, Morgan E, Tarr G, Coon M (1982) Purification and characterization of a unique isozyme of cytochrome P450 from liver microsomes of ethanol-treated rabbits. J Biol Chem 257: 8472–8480

    PubMed  CAS  Google Scholar 

  • Lambrecht R, Jacobs J, Sinclair P, Sinclair J (1990). Inhibition of uroporphyrinogen decarboxylase activity: the role of cytochrome P450-mediated uroporphyrinogen oxidation. Biochem J 269: 437–441

    PubMed  CAS  Google Scholar 

  • Lambrecht R, Sinclair P, Gorman N, Sinclair J (1992) Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450 1A2. Arch Biochem Biophy 294: 504–510

    Article  CAS  Google Scholar 

  • Lieber C (1988) Metabolic effects of ethanol and its interaction with other drugs, hepatotoxic agents, vitamins and carcinogens: a 1988 update. Semin Liver Dis 8: 47–68

    Article  PubMed  CAS  Google Scholar 

  • Linko P, Yeowell H, Gasiewicz T, Goldstein J (1986) Induction of cytochrome P450 by hexachlorobenzene in rats and aromatic hydrocarbon responsive mice. J Biochem Toxicol 1: 95–107

    Article  PubMed  CAS  Google Scholar 

  • Lorr N, Bloom S (1987) Ontogeny of the chicken cytochrome P450 enzyme system: expression and development of responsiveness to phenobarbital. Biochem Pharmacol 36: 3059–3067

    Article  PubMed  CAS  Google Scholar 

  • Lorr N, Bloom S, Park S, Gelboin H, Moller H, Freidman F (1989) Evidence for a PCN-P450 enzyme in chickens and comparison with that of other phenobarbital- inducible forms. Mol Pharmacol 35: 610–616

    PubMed  CAS  Google Scholar 

  • Lorr N, Hemendinger R, Bloom S, Sinclair P, Sinclair J (1991) Immunological detection and localization of P4501 in the avian immune system. Eastern Regional symposium on mechansim of immunotoxicology. 6th annual symposium (in press)

    Google Scholar 

  • Lubet R, Syi J, Nelson J, Nims R (1990) Induction of hepatic cytochrome P450-mediated alkoxyresorufin dealkylase activities in different species by prototype P450 inducers. Chem Biol Interact 75: 325–339

    Article  PubMed  CAS  Google Scholar 

  • Marks G (1978) The effects of chemicals on hepatic heme biosynthesis. In: De Matteis F, Aldridge W (eds) Heme and hemoproteins. Springer, Berlin Heidelberg New York, p 201

    Google Scholar 

  • May B, Hansen A (1989) Effect of haem on cytochrome P-450 synthesis. Clin Exp Pharmacol Physiol 16: 497–500

    Article  PubMed  CAS  Google Scholar 

  • May B, Borthwick I, Srivastava G, Pirola B, Elliott W (1986) Control of 5-aminolevulinate synthase in animals. Curr Top Cell Regul 28: 233–263

    PubMed  CAS  Google Scholar 

  • McPhaul M, Noble J, Simpson E, Mendelson C, Wilson J (1988) The expression of a functional cDNA encoding the chicken cytochrome P450arom (aromatase) that catalyzes the formation of estrogen from androgen. J Biol Chem 263: 16358–16363

    PubMed  CAS  Google Scholar 

  • Mercurio S, Nemeth A (1983) Regulation of monooxygenation during development of chick embryo liver: role of P450 isozymes and NADPH. Dev Pharmacol Ther 6: 94–109

    PubMed  CAS  Google Scholar 

  • Miller J, Miller E (1977) Ultimate chemical carcinogens as reactive mutagenic electrophiles. In: Hiatt H, Watson J, Winsten J (eds) Origins of human cancer. Cold Spring Harbor Laboratory, Cold Spring Harbor

    Google Scholar 

  • Misra R, Lorr N, Bloom S (1991) Cyclophosphamide metabolism in the primary immune organs of the chick: assays of drug activation, P450 expression and aldehyde dehydrogenase. Arch Toxicol 65: 32–38

    Article  PubMed  CAS  Google Scholar 

  • Moorthy B, Mandel M, Ghazarian J (1991) Amino terminal sequence homology of 2 chick kidney mitochondrial proteins isolated with monoclonal antibodies to the cytochrome P450 of 25-hydroxyvitamin D3-1 alpha-hydroxylase. J Bone Miner Res 6: 199–204

    Article  PubMed  CAS  Google Scholar 

  • Murti J, Adagia P, Padmanaban G (1991) Estradiol-17p induces polyaromatic hydrocarbon-inducible cytochrome P450 in chicken liver. Biochem Biophys Res Commun 175: 928–935

    Article  PubMed  CAS  Google Scholar 

  • Nakai K, Ward AM, Gannon M, Rifkind A (1992) p-Naphthoflavone induction of a cytochrome P450 arachidonic acid epoxygenase in chick embryo liver distinct from the arylhydrocarbon hydroxylase and from phenobarbital induced arachidonic epoxygenase. J Biol Chem 267: 19503–19512

    Google Scholar 

  • Nebert D, Nelson, S, Coon M et al. (1991) The cytochrome P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol 10: 1–14

    Article  PubMed  CAS  Google Scholar 

  • Nordman Y, de Verneuil H, Deybach JC, Delfau M, Grandchamp B (1990) Molecular genetics of porphyrias. Ann Med 22: 387–391

    Google Scholar 

  • Oron L, Bar-Nun S (1984) Immunological evidence for phenobarbital-stimulated synthesis of P450 in primary cultures of chick embryo hepatocytes. Biochim Biophys Acta 805: 291–299

    Article  PubMed  CAS  Google Scholar 

  • Peacock P (1956) Chemically induced tumors of fowls. Adv Cancer Res V: 179–198

    Google Scholar 

  • Poland A, Glover E (1973) Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene. Mol Pharmacol 10: 349–359

    Google Scholar 

  • Rangarajin P, Padmanaban G (1989) Regulation of cytochrome P450b/e gene expression by a heme- and phenobarbitone-modulated transcription factor. Proc Natl Acad Sci USA 86: 3963–3967

    Article  Google Scholar 

  • Ribereau-Gayon J, Peynaud E (1970) Biological occurrence and significance of alcohols in natural products. In: Tremolieres J (ed) Intl encyc pharmacol ther, vol 1. p 67

    Google Scholar 

  • Rifkind A, Petschke T (1981) p-Chloro n-methyl aniline demethylase activity in liver and extrahepatic tissues of the human fetus and in chick embryo liver. J Pharmacol Exp Ther 217: 572–278

    Google Scholar 

  • Rifkind A, Gillette P, Song C, Kappas A (1973) Drug stimulation of 5- aminolevulinate synthase and cytochrome P450 in ovo in chick embryo liver. J Pharmacol Exp Ther 185: 214–225

    PubMed  CAS  Google Scholar 

  • Rifkind A, Troeger M, Muschick H (1982) Kinetic evidence for heterogeneous responsiveness of mixed function oxidase isozymes to inhibition and induction by allylisopropylacetamide in chick embryo liver. J Biol Chem 257: 11717–11727

    PubMed  CAS  Google Scholar 

  • Rifkind A, Sassa S, Reyes J, Muschick H (1985) Polychlorinated aromatic hydrocarbon lethality, mixed function oxidase induction and UROD inhibition in the chick embryo: dissociation of dose-response relationships. Toxicol Appl Pharmacol 78: 268–279

    Article  PubMed  CAS  Google Scholar 

  • Rifkind A, Gannon M, Gross S (1990) Arachidonic acid metabolism by dioxin-induced cytochrome P450: a new hypothesis on the role of P450 in dioxin toxicity. Biochem Biophys Res Commun 172: 1180–1188

    Article  PubMed  CAS  Google Scholar 

  • Ronis M, Walker C (1989a) The monooxygenase of birds, reptiles, and amphibians. Xenobiotica 19: 1111–1121

    Article  PubMed  Google Scholar 

  • Ronis M, Walker C (1989b) The microsomal monooxygenases of birds. Rev Biochem Toxicol 10: 301–384

    CAS  Google Scholar 

  • Ryan G, Ades I (1989) Coordinate elevations of liver 5-aminolevulinate synthase and cytochrome P-50mRNA by phenobarbital in chicken embryos: the effects of heme. Int J Biochem 21: 1025–1031

    Article  PubMed  CAS  Google Scholar 

  • Sassa S, Granick S (1970) Induction of 5-aminolevulinic acid synthase in chick embryo liver cells in culture. Proc Natl Acad Sci USA 67: 517–522

    Article  PubMed  CAS  Google Scholar 

  • Schneider J, Sassa S, Kappas A (1983) Metabolism of estradiol in liver cell culture: differential responses of C-2 and C-16 oxidations to drugs and other chemicals that induce selective species of P450. J Clin Invest 72: 1420–1426

    Article  PubMed  CAS  Google Scholar 

  • Simmons D, Kasper C (1989) Quantitation of mRNAs specific for the mixed function oxidase system in rat liver and extrahepatic tissues during development. Arch Biochem Biophys 271: 10–20

    Article  PubMed  CAS  Google Scholar 

  • Sinclair J, Sinclair P, Smith L, Bement W, Pomeroy J, Bonkowsky H (1981) Ethanol-mediated increases in cytochrome P450 in cultured hepatocytes. Biochem Pharmacol 30: 2805–2809

    Article  PubMed  CAS  Google Scholar 

  • Sinclair J, Smith E, Bement W, Sinclair P, Bonkowsky H (1982) Increases in cytochrome P450 in cultured hepatocytes mediated by C3-C4 chain alcohols. Biochem Pharmacol 31: 2811–2815

    Article  PubMed  CAS  Google Scholar 

  • Sinclair J, Wiebkin P, Zaitlin L, Smith E, Sinclair P (1984) Aminopyrine and biphenyl metabolism in cultured hepatocytes: induction by alcohols. Biochem Pharmacol 33: 187–190

    Article  PubMed  CAS  Google Scholar 

  • Sinclair J, Cornell N, Zaitlin L, Hansch C (1986) Induction of cytochrome P450 by alcohols and pyrazoles: comparison of structure-activity relationships. Biochem Pharmacol 35: 707–710

    Article  PubMed  CAS  Google Scholar 

  • Sinclair J, Wood S, Smith L, Sinclair P, Koop D (1989) Comparison of the form(s) of cytochrome P450 induced by ethanol and glutethimide in cultured chick hepatocytes. Biochem Pharmacol 38: 657–664

    Article  PubMed  CAS  Google Scholar 

  • Sinclair J, Wood S, Lambrecht L, Gorman N, Mende-Mueller L, Smith L, Hunt J, Sinclair P (1990) Isolation of four forms of acetone-induced cytochrome P450 in chicken liver by hplc and their enzymic characterization. Biochem J 269: 85–91

    PubMed  CAS  Google Scholar 

  • Sinclair J, MacCaffrey J, Sinclair P, Bement W, Lambrecht L, Wood S, Smith L, Schenkman J, Guzelian P, Park S, Gelboin H (1991) Ethanol induces cytochromes P450IIE, IIB1/2, and III A in cultured rat hepatocytes. Arch Biochem Biophys 284: 360–365

    Article  PubMed  CAS  Google Scholar 

  • Sinclair P, Granick S (1974) Uroporphyrin formation induced by chlorinated hydrocarbons: requirements for iron, protein synthesis and drug metabolizing activity. Biochem Biophys Res Commun 61: 124–133

    Article  PubMed  CAS  Google Scholar 

  • Sinclair P, Lambrecht R, Sinclair J (1987) Evidence for cytochrome P450-mediated oxidation of uroporphyrinogen by cell-free liver extracts from chick embryos treated with 3-methylcholanthrene. Biochem Biophys Res Commun 146: 1324–1329

    Article  PubMed  CAS  Google Scholar 

  • Sinclair P, Frezza J, Sinclair J, Bement W, Haugen S, Healey J, Bonkovsky H (1989) Immunochemical detection of different isozymes of cytochrome P450 induced in chick hepatocyte cultures. Biochem J 258: 237–245

    PubMed  CAS  Google Scholar 

  • Sinclair P, Bement J, Haugen S, Sinclair J, May B, Li D, Schuetz E, Guzelian P (1990) Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix. Arch Biochem Biophys 282: 386–392

    Article  PubMed  CAS  Google Scholar 

  • Song B. Gelboin H, Park S, Yang C, Gonzalez F (1986) Complementary DNA and protein sequences of ethanol-inducible rat and human P450s: transcriptional and post-transcriptional regulation of the rat enzyme. J Biol Chem 261: 16689–16697

    Google Scholar 

  • Srivastava G, Hansen A, Bawden M, May B (1990) Hemin administration to rats reduces levels of hepatic mRNAs for phenobarbitone-inducible enzymes. Mol Pharmacol 38: 486–493

    PubMed  CAS  Google Scholar 

  • Strittmeyer C, Umberger F (1969) Oxidative enzyme components of avian liver microsomes. Biochim Biophys Acta 180: 18–27

    Article  Google Scholar 

  • Turner R, Graves J, Bell N (1987) Regulation of 25-hydroxyvitamin D3 metabolism in chick embryo. Am J Physiol 252: E38–E43

    PubMed  CAS  Google Scholar 

  • Venkateswar V, Padmanaban G (1991) Involvement of heme in the transcriptional activation of CYPIIB1/2 gene by phenobarbitone in rat liver: studies with succinylacetone. Arch Biochem Biophys 290: 167–172

    Article  PubMed  CAS  Google Scholar 

  • Watkins P, Wrighton S, Maurel P, Scheutz E, Mendez-Picon G, Parker G, Guzelian P (1985) Identification of an inducible from of cytochrome P450 in human liver. Proc Natl Acad Sci USA 82: 6310–6317

    Article  PubMed  CAS  Google Scholar 

  • Waxman D, Azaroff L (1992) Phenobarbitol induction of cytochrome P450 gene expression. Biochem J 281: 577–592

    PubMed  CAS  Google Scholar 

  • Waxman D, Dannan G, Guengerich F (1985) Regulation of rat hepatic cytochrome P450: age-dependent expression, hormonal imprinting and xenobiotic inducibility of sex-specific isoenzymes. Biochemistry 24: 4409–4417

    Article  PubMed  CAS  Google Scholar 

  • Wolf R, Seilman S, Oesch F, Mayer R, Burke M (1986) Multiple forms of cytochrome P450 related to forms induced marginally by phénobarbital: differences in the structure and in the metabolism of alkylresorufins. Biochem J 240: 27–33

    PubMed  CAS  Google Scholar 

  • Wrighton S, Maurel P, Schuetz P, Watkins P, Young B, Guzelian P (1985) Identification of the cytochrome P450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P450p. Biochemistry 24: 2171–2178

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. J. F. Sinclair
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. R. Sinclair
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, MC 1505, University of Connecticut Health Center, 263 Farmington Avenue, 06030, Farmington, CT, USA

    John B. Schenkman Ph.D.

  2. Institut für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung mbH, Ingolstädter Landstr. 1, W-8042, Neuherberg, Fed. Rep. of Germany

    Helmut Greim M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Sinclair, J.F., Sinclair, P.R. (1993). Avian Cytochrome P450. In: Schenkman, J.B., Greim, H. (eds) Cytochrome P450. Handbook of Experimental Pharmacology, vol 105. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77763-9_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77763-9_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77765-3

  • Online ISBN: 978-3-642-77763-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation