Avian Cytochrome P450

  • J. F. Sinclair
  • P. R. Sinclair
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 105)

Abstract

The cytochromes P450 are a family of hemoproteins that function within a membrane-bound electron transport chain to catalyze the oxidation of many endogenous and exogenous chemicals. Cytochrome P450 has been found in a wide diversity of phyla ranging from eukaryotes to humans. In this review, we describe the forms of cytochrome P450 characterized in avian species, concentrating mainly on those expressed in chickens. Two recent reviews of avian cytochrome P450 document the many observations with domestic and wild birds especially as these pertain to environmental exposure to inducing chemicals (Ronis and Walker 1989a,b). Recent developments reviewed here include the isolation and enzymic characterization of several induced chicken forms and the regulation of expression of these forms. Comparison of the avian forms with those of mammalian species will allow a better understanding of the multiplicity of cytochromes P450 required for metabolism of both endogenous and exogenous chemicals.

Keywords

Polycyclic Aromatic Hydrocarbon Testosterone Estradiol Porphyrin Pyrene 

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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. F. Sinclair
  • P. R. Sinclair

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