Does Smoking During Pregnancy Alter Brain Perfusion in the Neonate? A Doppler Study

  • Hashem Abdul-Khaliq
  • Hugo Segerer
  • Michael Obladen
Conference paper


Cerebral blood flow velocities (CBFVs) were significantly higher in 41 infants of smoking mothers compared to 59 control infants although gestational age, birth weight, and systolic blood pressure were lower in infants exposed to smoke prenatally. We speculate that increased CBFVs in these neonates are due to disturbed prostanoid synthesis.


Blood Flow Velocity Maternal Smoking Cerebral Blood Flow Velocity Doppler Examination Control Infant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Cerebral blood flow velocity


Arterial blood pressure


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ahlsten G, Ewald U, Tuvemu T (1987) Impaired vascular reactivity in newborns of smoking mothers. Acta Paediatr Scand 76: 248–253.PubMedCrossRefGoogle Scholar
  2. Bulterys MG, Greenland S, Kraus JF (1990) Chronic fetal hypoxia and sudden infant death syndrome: Interaction between maternal smoking and low hematocrit during pregnancy. Pediatrics 86: 535–540.PubMedGoogle Scholar
  3. Chaudhuri G, Heglund B, Meirik O (1991) Endothelium-derived vasoactive substances in fetal placental vessels. Seminar Perinatol 15: 4–10.Google Scholar
  4. Cnattingius S, Haglund B, Meirik O (1988) Cigarette smoke as risk factor for late fetal and early neonatal death. Br Med J 279: 258–261.CrossRefGoogle Scholar
  5. Dadak C, Leithner C, Sinzinger H (1981) Diminished prostacycline formation in umbilical arteries of babies born to women who smoke. Lancet i: 94.CrossRefGoogle Scholar
  6. Deeg KH, Rupprecht Th (1989) Pulsed Doppler sonographic measurement of normal values for the flow velocities in the intracranial arteries of healthy newboms. Pediatr Radiol 19: 71–78.PubMedCrossRefGoogle Scholar
  7. Leffler CB, Busija DW (1987) Arachidonic acid metabolites and perinatal cerebral hemodynamics. Seminar Perinatol 11: 31–42.Google Scholar
  8. Lindblad A, Marsal K, Andersson K-E (1988) Effect of nicotine on human fetal blood flow. Obstet Gynecol 72: 371–382.PubMedGoogle Scholar
  9. Merritt TA (1981). Smoking mothers affect little lives. Am J Dis Child 135: 501–502.PubMedGoogle Scholar
  10. Morrow RJ, Ritchie JWK, Bull SB (1988) Maternal cigarette smoking: The effects on umbilical and uterine blood flow velocity. Am J Obstet Gynecol 159: 1069–1071.PubMedGoogle Scholar
  11. Naeye RL, Peters EC (1984) Mental development of children whose mothers smoked during pregnancy and effects on the fetus. Obstet Gynecol 64: 601–607.PubMedGoogle Scholar
  12. Nash JE, Persaud TVN (1988) Embryopathic risks of cigarette smoking. Exp Pathol 33: 65–73.PubMedCrossRefGoogle Scholar
  13. Perlman JM (1985) Neonatal cerebral blood flow velocity measurement. Clin Perinatol 15: 179–193.Google Scholar
  14. Raju TNK (1991) Cerebral Doppler studies in the fetus and newborn infant. J Pediatr 119: 165–174.PubMedCrossRefGoogle Scholar
  15. Sokol JR, Drugan A, Evans M (1990) Substance abuse, smoking in pregnancy. In: Eden RD, Boehm FH (eds) Assessment and care of the fetus, physiological, clinical and medicolegal principles. Prentice-Hall International Inc., pp 687-691.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Hashem Abdul-Khaliq
  • Hugo Segerer
  • Michael Obladen

There are no affiliations available

Personalised recommendations