Quantitative Morphological Tests for Evaluation of Testicular Toxicity
Numerous recent publications attest to the substantial increase in public and scientific concern about the potential of industrial and environmental chemicals to interfere with male reproductive functions. While morphological investigations cannot reveal much about the mechanism of action of a compound, they can provide very useful information for direct subsequent studies specifically on affected cells or regions. This is certainly true for the testis. A good general tool for detecting testicular toxicity is undoubtedly a good histopathological evaluation. On the other hand, for defining the toxicological potency of a compound, quantification of toxic effects is necessary, which morphological studies do not automatically include, but which is able to provide valuable information for risk assessment of male reproductive toxicity.
KeywordsSertoli Cell Blood Testis Barrier Testicular Toxicity TCDD Treatment Dimethyl Methylphosphonate
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