Planning and Performance of Segment I, II and III Experiments: Practical Aspects and General Comments

  • Helmut Sterz
Conference paper


In investigations on reproduction toxicology — as is also the case with other toxicity studies — animals are used in place of man. However, if a hazard is to be detected and the risk for man assessed, then certain experimental conditions must be fulfilled.


DiGeorge Syndrome Suitable Species Cardiovascular Anomaly Rabbit Fetus Questionable Treatment 
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  1. Bacchus C, Sterz H, Buselmaier W, Sahai S, Winking H (1987) Genesis and systematization of cardiovascular anomalies and analysis of skeletal malformations in murine trisomy 16 and 19. Two animal models for human trisomies. Hum Genet 77: 12–22.PubMedCrossRefGoogle Scholar
  2. Barrow MV, Taylor WJ (1969) A rapid method for detecting malformations in rat fetuses. J Morphol 127: 291–306.PubMedCrossRefGoogle Scholar
  3. Binder M (1985) The teratogenic effects of a bis(dichloroacetyl)diamine on hamster embryos: aortic arch anomalies and the pathogenesis of the DiGeorge syndrome. Am J Pathol 118: 179–193.PubMedGoogle Scholar
  4. Roux C, Horvath C, Dupuis R (1979) Interpretation of the isolated agenesia of the hypophysis. Teratology 19(1): 39–41.PubMedCrossRefGoogle Scholar
  5. Staples RE (1974) Detection of visceral alterations in mammalian fetuses. Teratology 9: A37–A38.CrossRefGoogle Scholar
  6. Sterz H (1977) Routine examination of rat and rabbit fetuses for malformation of internal organs: Combination of Barrow’s and Wilson’s methods. In: D. Neubert, H.-J. Merker, T.E. Kwasigroch (eds), Methods in Prenatal Toxicology, G. Thieme Publishers, Stuttgart, pp 113–122.Google Scholar
  7. Sterz H, Lehmann H (1985) A critical comparison of the free-hand razor-blade dissection method according to Wilson with an in-situ sectioning method for rat fetuses. Teratogen Carcinogen Mutagen 5: 347–354.CrossRefGoogle Scholar
  8. Stuckhard JL, Poppe SM (1984) Fresh visceral examination of rat and rabbit fetuses used in teratogenicity testing. Teratogen Carcinogen Mutagen 4: 181–188.CrossRefGoogle Scholar
  9. Wilson JG (1965) Methods for administering agents and detect-ing malformations in experimental animals. In: JG Wilson, J Warkany (eds), Teratology: Principles and Techniques, University of Chicago Press, Chicago and London, pp 262–277.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Helmut Sterz

There are no affiliations available

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