Prenatal-Toxic Risk Estimation Based on Dose-Response Relationships and Molecular Dosimetry

  • Thomas Platzek
  • Gerd Bochert
  • Reinhard Meister
  • Diether Neubert


The final purpose of toxicological risk assessment is to determine a human exposure level with acceptable risk to the population. For the great majority of toxic effects the most frequently used approach is the NOAEL risk factor approach: 1. A dose is experimentally determined which induces “no effect” (“no-observed-adverse-effect-level”, NOAEL); 2. From this NOAEL a “safe dose” is assessed by division with an arbitrary factor.


Linear Extrapolation Probit Analysis Safe Dose NMRI Mouse Limb Abnormality 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Thomas Platzek
  • Gerd Bochert
  • Reinhard Meister
  • Diether Neubert

There are no affiliations available

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