The concept of restoring function in the central nervous system (CNS) by intracerebral grafting (ICG) is not new. As long ago as the sixteenth century the famous French surgeon Ambroise Paré (1510–1590) described a patient who “... had the idea his brain was rotten. He went to the King, begging him to command M. Le Grand, Physician, M. Pigray, King’s Surgeon-in-Ordinary and myself to open his head, remove his diseased brain and replace it with another. We did many things to him but it was impossible for us to restore his brain.” Obviously, they did not transplant any brain tissue, or did not do so successfully, but the idea was already there over 400 years ago .
KeywordsSynaptic Contact Afferent Input Surrounding Parenchyma Host Brain Intrinsic Neuron
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