Interleukin-4 (IL-4) und kutane T-Zell-Lymphome (CTCL)

  • O. Kohl
  • R. Dummer
  • J. Gillessen
  • G. Burg
Conference paper
Part of the Fortschritte der operativen und onkologischen Dermatologie book series (OP.DERMATOLOGIE, volume 7)

Zusammenfassung

Bei der Untersuchung des Proliferations- und Zytotoxizitätsverhaltens der peripheren mononukleären Zellen (PMC) von Normal- (n = 28) und Lymphompatienten (CTCL; n = 18; 15×Mycosis fungoides, 2×pleomorphes T-Zell-Lymphom, 1×Granulomatous Slack Skin Disease) zeigte sich eine stark verringerte Proliferation nach PHA-Stimulation und eine verminderte Zytotoxizität der Zellen der CTCL-Patienten auf IL-4. Im Gegensatz dazu wiesen die Lymphompatienten deutlich höhere IL-4- und lösliche Interleukin-2 Rezeptor (IL-2- R)-Spiegel im Kulturüberstand nach PHA-Stimulation auf. IL-4 abhängige Funktionen scheinen bei den CTCL-Patienten überrepräsentiert zu sein, so daß IL-4 an der Pathogenese der kutanen T-Zell-Lymphome beteiligt sein könnte. Eine weitere funktionelle Charakterisierung der humanen T-Helferzellen in die TH1- und TH2-Subgruppen könnte Aufschlüsse bringen in der Frage, ob bei CTCL eine Überexpression des TH2-Zytokinmusters vorliegt.

Schlüsselwörter

Interleukin-4 Kutane T-Zell-Lymphome Proliferation Zytotoxizität 

Summary

We analyzed peripheral mononuclear cells (PMC) of normal donors (n = 28) and of patients with cutaneous T-cell lymphomas (CTCL; n = 18; 15×mycosis fungoides, 2×pleomorphic T-cell lymphoma, 1×granulomatous slack skin disease). The PMC of the CTCL patients proliferated less than those of the normal donors after stimulation with PHA and their cytotoxicity was also much lower. We found that CTCL patients had a significantly higher IL-4 and soluble Interleukin-2 receptor level of the supernatants (after 3 days of stimulation with PHA). IL-4-dependent functions seem to predominate. Therefore, IL-4 could play a crucial part in the pathogenesis of CTCL. Further functional differentiation and characterization of human T-helper cells into TH1 and TH2 subgroups could help to settle, whether CTCL show an increase of the TH2 dependent cytokine pattern.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • O. Kohl
  • R. Dummer
  • J. Gillessen
  • G. Burg

There are no affiliations available

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